PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
14991081-3	2003	In the present study we investigated the effects of the flurbiprofen enantiomers on the stimulated release of calcitonin gene-related peptide (CGRP) from the isolated rat skin as an indirect measure of peripheral nociceptor activation and "neurogenic inflammation".	Flurbiprofen	56-68	calcitonin-related polypeptide alpha	Rattus norvegicus	110-141	
14991081-3	2003	In the present study we investigated the effects of the flurbiprofen enantiomers on the stimulated release of calcitonin gene-related peptide (CGRP) from the isolated rat skin as an indirect measure of peripheral nociceptor activation and "neurogenic inflammation".	Flurbiprofen	56-68	calcitonin-related polypeptide alpha	Rattus norvegicus	143-147	
14991081-9	2003	In contrast, S(+)-flurbiprofen - only at 10(-6) M - significantly reduced the inflammatory mediator-induced CGRP release.	Flurbiprofen	14-30	calcitonin-related polypeptide alpha	Rattus norvegicus	108-112	
14991081-11	2003	CONCLUSION: Although a higher concentration of the effective enantiomer was needed to inhibit stimulated CGRP than PGE(2) release, flurbiprofen seems to exert the antinociceptive/antiinflammatory effects observed by preventing the secondary cutaneous prostaglandin formation that appears necessary to enable activation by inflammatory mediators of the CGRP-releasing nerve fibers.	Flurbiprofen	131-143	calcitonin-related polypeptide alpha	Rattus norvegicus	352-356	
12791437-0	2003	S+ -flurbiprofen but not 5-HT1 agonists suppress basal and stimulated CGRP and PGE2 release from isolated rat dura mater.	Flurbiprofen	0-16	calcitonin-related polypeptide alpha	Rattus norvegicus	70-74	
12566162-0	2003	Flurbiprofen inhibits capsaicin induced calcitonin gene related peptide release from rat spinal cord via an endocannabinoid dependent mechanism.	Flurbiprofen	0-12	calcitonin-related polypeptide alpha	Rattus norvegicus	40-71	
12566162-3	2003	Similarly, flurbiprofen (3 microM) inhibited spinal CGRP release.	Flurbiprofen	11-23	calcitonin-related polypeptide alpha	Rattus norvegicus	52-56	
12566162-7	2003	In conclusion the present work provides evidence on the shift of arachidonic acid metabolism towards endocannabinoids formation in response to COX inhibition as a mechanism for flurbiprofen inhibitory effect on spinal CGRP release.	Flurbiprofen	177-189	calcitonin-related polypeptide alpha	Rattus norvegicus	218-222