PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34090906-10 2021 The urine samples were collected for the analysis of FLU-NAC conjugate by UPLC-Q-Orbitrap MS. Flutamide 53-56 NLR family, pyrin domain containing 1A Mus musculus 57-60 34090906-17 2021 Mass spectrometry analysis identified the presence of FLU reactive metabolite derived FLU-NAC conjugate in the urine of mice treated with FLU. Flutamide 54-57 NLR family, pyrin domain containing 1A Mus musculus 90-93 34090906-17 2021 Mass spectrometry analysis identified the presence of FLU reactive metabolite derived FLU-NAC conjugate in the urine of mice treated with FLU. Flutamide 138-141 NLR family, pyrin domain containing 1A Mus musculus 90-93 34090906-18 2021 Strikingly, about a two-fold increase of the FLU-NAC conjugate was detected when treated with both FLU and XLGB, indicating an elevated amount of toxic metabolite produced from FLU in the present of XLGB. Flutamide 45-48 NLR family, pyrin domain containing 1A Mus musculus 49-52 34090906-18 2021 Strikingly, about a two-fold increase of the FLU-NAC conjugate was detected when treated with both FLU and XLGB, indicating an elevated amount of toxic metabolite produced from FLU in the present of XLGB. Flutamide 99-102 NLR family, pyrin domain containing 1A Mus musculus 49-52 34090906-18 2021 Strikingly, about a two-fold increase of the FLU-NAC conjugate was detected when treated with both FLU and XLGB, indicating an elevated amount of toxic metabolite produced from FLU in the present of XLGB. Flutamide 177-180 NLR family, pyrin domain containing 1A Mus musculus 49-52 34090906-20 2021 This increased hepatoxicity was mediated through the induction of CYP1A2 activity which in turn enhanced bioactivation of FLU leading to over production of FLU-NAC conjugate and oxidative stress. Flutamide 122-125 NLR family, pyrin domain containing 1A Mus musculus 160-163 34090906-20 2021 This increased hepatoxicity was mediated through the induction of CYP1A2 activity which in turn enhanced bioactivation of FLU leading to over production of FLU-NAC conjugate and oxidative stress. Flutamide 156-159 NLR family, pyrin domain containing 1A Mus musculus 160-163