PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29391997-6 2015 There was a positive correlation between IFN-gamma and vitamin D levels (p<0.05) in the study group, whereas IgE, IL-4, and IL-10 levels showed a negative correlation with vitamin D3 levels (p<0.05). Cholecalciferol 175-185 interleukin 10 Homo sapiens 127-132 26943970-0 2016 Vitamin D3 alters microglia immune activation by an IL-10 dependent SOCS3 mechanism. Cholecalciferol 0-10 interleukin 10 Homo sapiens 52-57 26943970-8 2016 Most importantly, the activated microglia exposed to vitamin D3 had reduced expression of pro-inflammatory cytokines, IL-6, IL-12, and TNFalpha, and increased expression of IL-10. Cholecalciferol 53-63 interleukin 10 Homo sapiens 173-178 26943970-10 2016 Therefore, vitamin D3 increases the expression of IL-10 creating a feedback loop via SOCS3 that downregulates the pro-inflammatory immune response by activated microglia which would likewise prevent immune mediated damage in the CNS. Cholecalciferol 11-21 interleukin 10 Homo sapiens 50-55 24374976-9 2014 RESULTS: Compared with baseline values, LPS-matured mo-DC exhibited reduced expression of CD80 and reduced production of the cytokines IL-10, IL-1beta, and IL-6 following 26 weeks of oral vitamin D3 supplementation. Cholecalciferol 188-198 interleukin 10 Homo sapiens 135-140 23612780-5 2014 However, 100 nM of vitamin D3 significantly increased the release of IL-10, but suppressed the production of IL-2, IL-6, interferon gamma and TNF alpha in the culture supernatants of both groups. Cholecalciferol 19-29 interleukin 10 Homo sapiens 69-74 26401986-11 2015 CONCLUSION: IL-10 levels increased significantly in RRMS patients after taking high-dose vitamin D3 for 3 months. Cholecalciferol 89-99 interleukin 10 Homo sapiens 12-17 25236584-0 2014 Vitamin D3 metabolite calcidiol primes human dendritic cells to promote the development of immunomodulatory IL-10-producing T cells. Cholecalciferol 0-10 interleukin 10 Homo sapiens 108-113 16341266-1 2006 We previously reported that human CD4+ Tregs secrete high levels of IL-10 when stimulated in the presence of dexamethasone and calcitriol (vitamin D3). Cholecalciferol 139-149 interleukin 10 Homo sapiens 68-73 20510731-5 2010 Type-1 T regulatory (Tr1) cells, CD46-stimulated IL-10-secreting T cells, and IL-10-secreting T cells induced by vitamin D3 (VitD3) and dexamethasone (Dex) are induced populations with significant regulatory activities. Cholecalciferol 113-123 interleukin 10 Homo sapiens 78-83 19538496-9 2009 Existing therapies including corticosteroids and allergen immunotherapy act on Tregs, in part to increase IL-10 production, while vitamin D3 and long-acting beta-agonists enhance IL-10 Treg function. Cholecalciferol 130-140 interleukin 10 Homo sapiens 179-184 24277747-14 2014 TNF-alpha/IL-10 expressing CD3(+)/4(+) cell ratios were significantly decreased with 100 nM of vitamin D3 (31.3 +- 9.4, P < 0.05) when compared with controls (40.4 +- 11.3) in vitro. Cholecalciferol 95-105 interleukin 10 Homo sapiens 10-15 24277747-15 2014 Additionally, INF-gamma/IL-10 expressing CD3(+)/4(+) cell ratio was significantly decreased with 100 nM of vitamin D3 (12.1 +- 4.0, P < 0.05) when compared with controls (14.8 +- 4.6). Cholecalciferol 107-117 interleukin 10 Homo sapiens 24-29 23710204-6 2013 Vitamin D3 acted in synergy with the TLR agonists LPS and peptidoglycan (PGN) in inducing IL-6, IL-8, and IL-10, whereas vitamin D3 completely inhibited LPS-induced secretion of IL-12. Cholecalciferol 0-10 interleukin 10 Homo sapiens 106-111 18178824-6 2008 PHA and IL-2 stimulation as well as vitamin D3/dexamethasone and anti-CD2/CD16 mAbs are demonstrated to induce IL-10 expression in NK cells. Cholecalciferol 36-46 interleukin 10 Homo sapiens 111-116 18387750-6 2008 The central nervous system converts vitamin D3 into 1,25-dihydroxyvitamin D3 (1,25-(OH)2 D3), a biologically active hormone with anti-inflammatory and neuro-protective functions that depend on IL-10-producing regulatory lymphocytes. Cholecalciferol 36-46 interleukin 10 Homo sapiens 193-198 18387750-9 2008 We hypothesize that vIL-10 may induce a dysfunction of IL-10-producing regulatory lymphocytes, thereby undermining the protective functions of sunlight, vitamin D3, and 1,25-(OH)2 D3. Cholecalciferol 153-163 interleukin 10 Homo sapiens 21-26 16924108-3 2006 We report that OX40 ligand (OX40L) completely inhibited the generation of IL-10-producing Tr1 cells from naive and memory CD4(+) T cells induced by the immunosuppressive drugs dexamethasone and vitamin D3. Cholecalciferol 194-204 interleukin 10 Homo sapiens 74-79 16341266-8 2006 We show here that administration of vitamin D3 to healthy individuals and SR asthmatic patients enhanced subsequent responsiveness to dexamethasone for induction of IL-10. Cholecalciferol 36-46 interleukin 10 Homo sapiens 165-170 16341266-5 2006 Addition of vitamin D3 with dexamethasone to cultures of SR CD4+ T cells enhanced IL-10 synthesis to levels observed in cells from glucocorticoid-sensitive patients cultured with dexamethasone alone. Cholecalciferol 12-22 interleukin 10 Homo sapiens 82-87 34725288-7 2021 The women, who received the course of the preventive therapy with metformin, vitamin D3 and corvitin, showed a decrease in the concentration of pro-inflammatory cytokines and an increase in anti-inflammatory cytokine IL-10, normalization of the balance between iNOS and arginase activity, and the normalization of the M1 / M2 macrophages ratio. Cholecalciferol 77-87 interleukin 10 Homo sapiens 217-222 34101754-0 2021 Vitamin D3 attenuates doxorubicin-induced senescence of human aortic endothelial cells by upregulation of IL-10 via the pAMPKalpha/Sirt1/Foxo3a signaling pathway. Cholecalciferol 0-10 interleukin 10 Homo sapiens 106-111 34101754-4 2021 We further show the protective effects of vitamin D3 are mediated by the upregulation of IL-10 and FOXO3a expression through fine modulation of pAMPKalpha/SIRT1/FOXO3a complex activity. Cholecalciferol 42-52 interleukin 10 Homo sapiens 89-94 32251441-1 2020 BACKGROUND & AIMS: In our previous study, a Seesaw model was proposed for the fluctuation of crucial anti- (IL-10) and pro-inflammatory (Il-6 & IL-17A) cytokines through vitamin D3. Cholecalciferol 170-180 interleukin 10 Homo sapiens 108-113 35485195-6 2022 RESULTS: It was observed that vitamin D3 reduced expression of IFN-gamma, IL-4, IL-5, and IL-10 genes by 73, 50, 37, and 29%, respectively, and increased IL-2 gene expression by 31% (p <= 0.05). Cholecalciferol 30-40 interleukin 10 Homo sapiens 90-95 32251441-7 2020 In addition, the plasma levels of IL-27, TGF-beta1, IL-10, IL-17A, and IL-6 significantly changed following the administration of vitamin D3. Cholecalciferol 130-140 interleukin 10 Homo sapiens 52-57 29431349-3 2018 The aim of our study was to evaluate the effect of active vitamin D3 (VD) on the expression of pro-inflammatory and anti-inflammatory cytokines (IL-6, IL-8, IL-10 and IL-12) in human gingival fibroblasts (hGF) and human periodontal ligament cells (hPDLc) triggered by Porphyromonas gingivalis and Streptococcus pyogenes. Cholecalciferol 58-68 interleukin 10 Homo sapiens 157-162 30533524-5 2018 Results: Vitamin D3 affected the levels of IL-17A, IL-10, and IL-6 among the 3 groups (p < 0.001 for all). Cholecalciferol 9-19 interleukin 10 Homo sapiens 51-56 30533524-8 2018 Conclusions: Although supplementation with vitamin D3 reduced the mRNA expression levels of IL-17A and IL-6, it increased the mRNA expression level of IL-10 in all groups. Cholecalciferol 43-53 interleukin 10 Homo sapiens 151-156 30246694-0 2018 Vitamin D3 Induced Decrease in IL-17 and Malondialdehyde, and Increase in IL-10 and Total Antioxidant Capacity Levels in Patients with Irritable Bowel Syndrome. Cholecalciferol 0-10 interleukin 10 Homo sapiens 74-79 30246694-8 2018 CONCLUSION: Vitamin D3 supplementation reduces the serum IL-17 and MDA levels, and augments the serum IL-10 and TAC levels in IBS patients, particularly in IBS-D subtype. Cholecalciferol 12-22 interleukin 10 Homo sapiens 102-107 31124381-11 2020 However, treatment initiation significantly improved plasma IL-10 levels after 2 months in both placebo and cholecalciferol groups. Cholecalciferol 108-123 interleukin 10 Homo sapiens 60-65 28332200-3 2017 The direct actions of vitamin D3 on naive T cells result in the proliferation of more regulatory T cells and inhibitory cytokines such as IL-4, IL-10 and IL-5. Cholecalciferol 22-32 interleukin 10 Homo sapiens 144-149 27622485-0 2016 Dendritic cells generated in the presence of vitamin D3 and stimulated with lipopolysaccharide secrete IL-8, IL-1beta, IL-10 and induce relatively low levels of CD4+CD25hiFoxp3+ T cells. Cholecalciferol 45-55 interleukin 10 Homo sapiens 119-124