PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24169587-2 2013 Our results indicate that 1,25(OH)2D3, the biologically active metabolite of vitamin D3, calcipotriol and FTY720 augment IL-2-activated NK cell lysis of K562 and RAJI tumor cell lines as well as immature (i) and mature (m) DCs, with variable efficacies. Cholecalciferol 77-87 interleukin 2 Homo sapiens 121-125 23612780-0 2014 The in vitro treatment with vitamin D3 is ineffective on the expression of PKC isoenzymes, but decreases further the impaired production of IL-2 in the T lymphocytes of SLE patients. Cholecalciferol 28-38 interleukin 2 Homo sapiens 140-144 23612780-1 2014 The objective of the study was to investigate the possibility whether the in vitro treatment with vitamin D3 can restore the impaired expression of protein kinase C (PKC) isoenzymes and IL-2 production in the lymphocytes of patients with systemic lupus erythematosus (SLE). Cholecalciferol 98-108 interleukin 2 Homo sapiens 186-190 23612780-5 2014 However, 100 nM of vitamin D3 significantly increased the release of IL-10, but suppressed the production of IL-2, IL-6, interferon gamma and TNF alpha in the culture supernatants of both groups. Cholecalciferol 19-29 interleukin 2 Homo sapiens 109-113 23612780-6 2014 As the low production of IL-2 is one of the main pathologic features of SLE, we recommend to avoid the use of high doses of vitamin D3 for treatment of lupus patients with vitamin D3 deficiency. Cholecalciferol 124-134 interleukin 2 Homo sapiens 25-29 23612780-6 2014 As the low production of IL-2 is one of the main pathologic features of SLE, we recommend to avoid the use of high doses of vitamin D3 for treatment of lupus patients with vitamin D3 deficiency. Cholecalciferol 172-182 interleukin 2 Homo sapiens 25-29 2521453-5 1989 Thus, in the presence of the vitamin D3 metabolite, only one-hundredth the concentration of CsA was required to produce the same effect on IL-2 production as that produced by CsA alone. Cholecalciferol 29-39 interleukin 2 Homo sapiens 139-143 7565732-0 1995 Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp/AP-1 complex formation by a nuclear hormone receptor. Cholecalciferol 56-66 interleukin 2 Homo sapiens 34-47 35485195-6 2022 RESULTS: It was observed that vitamin D3 reduced expression of IFN-gamma, IL-4, IL-5, and IL-10 genes by 73, 50, 37, and 29%, respectively, and increased IL-2 gene expression by 31% (p <= 0.05). Cholecalciferol 30-40 interleukin 2 Homo sapiens 154-158 7565732-1 1995 T-lymphocyte proliferation is suppressed by 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the active metabolite of vitamin D3, and is associated with a decrease in interleukin 2 (IL-2), gamma interferon, and granulocyte-macrophage colony-stimulating factor mRNA levels. Cholecalciferol 58-68 interleukin 2 Homo sapiens 173-177 7565732-3 1995 We therefore examined vitamin D3-mediated repression of activated IL-2 expression by cotransfecting Jurkat cells with IL-2 promoter/reporter constructs and a VDR overexpression vector and by DNA binding. Cholecalciferol 22-32 interleukin 2 Homo sapiens 66-70 7565732-3 1995 We therefore examined vitamin D3-mediated repression of activated IL-2 expression by cotransfecting Jurkat cells with IL-2 promoter/reporter constructs and a VDR overexpression vector and by DNA binding. Cholecalciferol 22-32 interleukin 2 Homo sapiens 118-122 2548278-0 1989 Inhibition of human natural killer cell and lymphokine-activated killer cell cytotoxicity and differentiation by vitamin D3. Cholecalciferol 113-123 interleukin 2 Homo sapiens 44-54 2548278-2 1989 The effect of vitamin D3 and 1,25(OH)2D3 on human natural killer (NK) cells and their activation by interferon (IFN) and interleukin 2 (IL-2) was investigated. Cholecalciferol 14-24 interleukin 2 Homo sapiens 121-134 2548278-7 1989 Vitamin D3 inhibited both IFN and IL-2 activation of NK activity. Cholecalciferol 0-10 interleukin 2 Homo sapiens 34-38 2548278-8 1989 However, increasing doses of IL-2 were able to abrogate the inhibition caused by vitamin D3. Cholecalciferol 81-91 interleukin 2 Homo sapiens 29-33 2548278-9 1989 Vitamin D3 was able to inhibit NK activity of phytohaemagglutinin and IL-2-activated cells, and also inhibit the proliferation and lymphokine-activated killer activity induced by IL-2. Cholecalciferol 0-10 interleukin 2 Homo sapiens 70-74 2548278-9 1989 Vitamin D3 was able to inhibit NK activity of phytohaemagglutinin and IL-2-activated cells, and also inhibit the proliferation and lymphokine-activated killer activity induced by IL-2. Cholecalciferol 0-10 interleukin 2 Homo sapiens 131-141 2548278-9 1989 Vitamin D3 was able to inhibit NK activity of phytohaemagglutinin and IL-2-activated cells, and also inhibit the proliferation and lymphokine-activated killer activity induced by IL-2. Cholecalciferol 0-10 interleukin 2 Homo sapiens 179-183 2548278-11 1989 NA cells pretreated with low doses of IL-2 were sensitive to inhibition by vitamin D3 while those pretreated with high doses of IL-2 were not. Cholecalciferol 75-85 interleukin 2 Homo sapiens 38-42 2466090-4 1988 The presence of vitamin D3 reduced IFN-gamma titers when PHA and IL-2 were used to induce IFN, but not when ionomycin was used as the inducer. Cholecalciferol 16-26 interleukin 2 Homo sapiens 65-69 3257676-6 1988 Suppression of PBMC proliferation by vitamin D3 analogs seemed to be a secondary effect of their inhibition of IL-2 production. Cholecalciferol 37-47 interleukin 2 Homo sapiens 111-115 3257676-0 1988 Biological activity of 26,26,26,27,27,27-hexafluorinated analogs of vitamin D3 in inhibiting interleukin-2 production by peripheral blood mononuclear cells stimulated by phytohemagglutinin. Cholecalciferol 68-78 interleukin 2 Homo sapiens 93-106 3266311-4 1988 This fact suggests that 1 alpha-OHD3 therapy may be useful for the restoration of IL-2 production in hemodialysis patients, and that the vitamin D3 deficiency may be responsible for the impairment of cellular immunity associated with IL-2 production disorder in hemodialysis patients. Cholecalciferol 137-147 interleukin 2 Homo sapiens 234-238 6427926-1 1984 The hormonal form of vitamin D3, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], at picomolar concentrations, inhibited the growth-promoting lymphokine interleukin-2, which is produced by human T lymphocytes activated in vitro by the mitogen phytohemagglutinin. Cholecalciferol 21-31 interleukin 2 Homo sapiens 144-157 6427926-2 1984 Other metabolites of vitamin D3 were less effective than 1,25(OH)2D3 in suppressing interleukin-2; their order of potency corresponded to their respective affinity for the 1,25(OH)2D3 receptor, suggesting that the effect on interleukin-2 was mediated by this specific receptor. Cholecalciferol 21-31 interleukin 2 Homo sapiens 84-97 6427926-2 1984 Other metabolites of vitamin D3 were less effective than 1,25(OH)2D3 in suppressing interleukin-2; their order of potency corresponded to their respective affinity for the 1,25(OH)2D3 receptor, suggesting that the effect on interleukin-2 was mediated by this specific receptor. Cholecalciferol 21-31 interleukin 2 Homo sapiens 224-237