PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22778074-10 2014 AChE activity was inhibited by acephate. acephate 31-39 acetylcholinesterase Rattus norvegicus 0-4 3798464-7 1986 It is also proposed that acephate prevented the initial competitive binding of methamidophos to the AChE active site and delayed the initial sequence of events essential for phosphorylation of AChE. acephate 25-33 acetylcholinesterase Rattus norvegicus 100-104 3798464-7 1986 It is also proposed that acephate prevented the initial competitive binding of methamidophos to the AChE active site and delayed the initial sequence of events essential for phosphorylation of AChE. acephate 25-33 acetylcholinesterase Rattus norvegicus 193-197 3608937-6 1987 Similar changes occurred in rats exposed to 10 mg of acephate/kg.day; however, plasma cholinesterase and RBC acetylcholinesterase activities were inhibited. acephate 53-61 acetylcholinesterase Rattus norvegicus 109-129 3798464-0 1986 Kinetic analysis of acetylcholinesterase inhibition by combinations of acephate and methamidophos. acephate 71-79 acetylcholinesterase Rattus norvegicus 20-40 3798464-1 1986 Acephate pre-exposure provided protection against the inhibition of RBC and brain acetylcholinesterase (AChE), and plasma cholinesterase (ChE) activities in rats exposed to both acephate and methamidophos. acephate 0-8 acetylcholinesterase Rattus norvegicus 82-102 3798464-1 1986 Acephate pre-exposure provided protection against the inhibition of RBC and brain acetylcholinesterase (AChE), and plasma cholinesterase (ChE) activities in rats exposed to both acephate and methamidophos. acephate 0-8 acetylcholinesterase Rattus norvegicus 104-108 3798464-2 1986 In vitro addition of acephate to AChE prior to or with methamidophos also provided complete protection against AChE inhibition by methamidophos. acephate 21-29 acetylcholinesterase Rattus norvegicus 33-37 3798464-2 1986 In vitro addition of acephate to AChE prior to or with methamidophos also provided complete protection against AChE inhibition by methamidophos. acephate 21-29 acetylcholinesterase Rattus norvegicus 111-115 3798464-4 1986 Since acephate has greater affinity than does methamidophos for the AChE active site (Singh, A.K., Toxicol. acephate 6-14 acetylcholinesterase Rattus norvegicus 68-72 3798464-6 1986 Pharmacol., 81 (1985) 302), it is proposed that acephate provided protection by binding with the AChE active site and, therefore, preventing methamidophos from binding with the enzyme. acephate 48-56 acetylcholinesterase Rattus norvegicus 97-101 16563591-6 2006 The exposure to AChE inhibiting pesticides for the general population at P99.9, represented 33.6% of the ARfD as methamidophos and 70.2% ARfD as acephate. acephate 145-153 acetylcholinesterase Rattus norvegicus 16-20 2097819-5 1990 Acephate was a potent inhibitor of cockroach AChE, but a poor inhibitor of rat AChE. acephate 0-8 acetylcholinesterase Rattus norvegicus 45-49 2097819-5 1990 Acephate was a potent inhibitor of cockroach AChE, but a poor inhibitor of rat AChE. acephate 0-8 acetylcholinesterase Rattus norvegicus 79-83 2097819-7 1990 Acephate exhibited greater affinity for the cockroach-AChE than for the rat-AChE, and acephate phosphorylated the cockroach-AChE several times faster than the rat enzyme. acephate 0-8 acetylcholinesterase Rattus norvegicus 54-58 2097819-7 1990 Acephate exhibited greater affinity for the cockroach-AChE than for the rat-AChE, and acephate phosphorylated the cockroach-AChE several times faster than the rat enzyme. acephate 0-8 acetylcholinesterase Rattus norvegicus 76-80 2097819-7 1990 Acephate exhibited greater affinity for the cockroach-AChE than for the rat-AChE, and acephate phosphorylated the cockroach-AChE several times faster than the rat enzyme. acephate 0-8 acetylcholinesterase Rattus norvegicus 76-80 2097819-9 1990 Solubilization of AChE by Triton X-100 altered the kinetics of inhibition of rat AChE by acephate. acephate 89-97 acetylcholinesterase Rattus norvegicus 18-22 2097819-9 1990 Solubilization of AChE by Triton X-100 altered the kinetics of inhibition of rat AChE by acephate. acephate 89-97 acetylcholinesterase Rattus norvegicus 81-85 2097819-12 1990 The mechanism of acephate-cockroach AChE interaction was different than the mechanism of acephate-rat AChE interaction. acephate 17-25 acetylcholinesterase Rattus norvegicus 36-40 2097819-12 1990 The mechanism of acephate-cockroach AChE interaction was different than the mechanism of acephate-rat AChE interaction. acephate 89-97 acetylcholinesterase Rattus norvegicus 102-106 2097819-15 1990 It is also proposed that the ED site in cockroach-AChE may be situated in or adjacent to the active site and, therefore, acephate may be bound to the ED site such that the phosphate moiety of acephate interacts with the enzyme"s "esteratic" site. acephate 121-129 acetylcholinesterase Rattus norvegicus 50-54 2097819-15 1990 It is also proposed that the ED site in cockroach-AChE may be situated in or adjacent to the active site and, therefore, acephate may be bound to the ED site such that the phosphate moiety of acephate interacts with the enzyme"s "esteratic" site. acephate 192-200 acetylcholinesterase Rattus norvegicus 50-54 2097819-17 1990 This study also indicated that the ED site in rat-AChE may be peripheral to the active site, and that the binding of acephate to this site prevented the phosphorylation by methamidophos of the rat-AChE. acephate 117-125 acetylcholinesterase Rattus norvegicus 50-54 14694584-0 2002 [Comparison of the toxic effect of methamidophos and acephate on acetylcholinesterase]. acephate 53-61 acetylcholinesterase Rattus norvegicus 65-85 14694584-6 2002 When rats being administrated with acephate, there was 31.68% of inhibition on the brain stem, but no significant inhibition in other brain region was noticed, while methamidophos had a strong inhibitory effect on the activity of AChE in all brain regions, especially the cerebellum and brain-stem(71.51% and 61.85% respectively). acephate 35-43 acetylcholinesterase Rattus norvegicus 230-234 14694584-7 2002 CONCLUSION: Acephate and methamidophos could directly inhibit the AChE activities in vitro, but the inhibition degree was different. acephate 12-20 acetylcholinesterase Rattus norvegicus 66-70 2097819-17 1990 This study also indicated that the ED site in rat-AChE may be peripheral to the active site, and that the binding of acephate to this site prevented the phosphorylation by methamidophos of the rat-AChE. acephate 117-125 acetylcholinesterase Rattus norvegicus 197-201