PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34847624-0 2022 Alnustone inhibits the growth of hepatocellular carcinoma via ROS- mediated PI3K/Akt/mTOR/p70S6K axis. ros 62-65 AKT serine/threonine kinase 1 Homo sapiens 81-84 33791071-0 2021 Pegylated Recombinant Human Arginase 1 Induces Autophagy and Apoptosis via the ROS-Activated AKT/mTOR Pathway in Bladder Cancer Cells. ros 79-82 AKT serine/threonine kinase 1 Homo sapiens 93-96 33791071-12 2021 Finally, BCT-100 was demonstrated to induce autophagy and apoptosis via the ROS-mediated AKT/mTOR signaling pathway in bladder cancer cells. ros 76-79 AKT serine/threonine kinase 1 Homo sapiens 89-92 33799790-0 2021 Tioconazole and Chloroquine Act Synergistically to Combat Doxorubicin-Induced Toxicity via Inactivation of PI3K/AKT/mTOR Signaling Mediated ROS-Dependent Apoptosis and Autophagic Flux Inhibition in MCF-7 Breast Cancer Cells. ros 140-143 AKT serine/threonine kinase 1 Homo sapiens 112-115 34963561-4 2022 In addition, DNR induced NOX4-dependent ROS production, leading to the activation of p38 MAPK and inactivation of Akt and ERK. ros 40-43 AKT serine/threonine kinase 1 Homo sapiens 114-117 34843737-8 2022 Pretreating cultured keratinocytes with antioxidant or AKT inhibitor significantly reduced the UVB-induced ROS, cell proliferation, and pAKT expression. ros 107-110 AKT serine/threonine kinase 1 Homo sapiens 55-58 34951363-5 2021 Signaling pathways such as NF-kappaB, MAPKs, PI3K/Akt/ mTOR and Keap1-Nrf2-ARE modulates the detrimental effects of oxidative stress by increasing the expression of cellular antioxidant defenses, phase II detoxification enzymes and decreased production of ROS. ros 256-259 AKT serine/threonine kinase 1 Homo sapiens 50-53 34468815-8 2021 Nox4 was significantly upregulated only in CMD-exposed ABCs and NOX4 activation of PI3K/AKT can lead to increased ROS levels in human cancer cells. ros 114-117 AKT serine/threonine kinase 1 Homo sapiens 88-91 34311033-7 2021 Furthermore, we confirmed the role of TRPC3 and the ROCE-AKT/GSK3beta-CNB2/NFATc2 signaling cascade in regulating cell cycle checkpoint, apoptosis cascade, and intracellular ROS production in GC. ros 174-177 AKT serine/threonine kinase 1 Homo sapiens 57-60 34708887-8 2022 In summary, PM2.5 -induced NOX up-regulation is the source of ROS in EA.hy926, which activated AKT/eNOS/NO signal response leading to endothelial dysfunction and inflammatory damage in EA.hy926 cells. ros 62-65 AKT serine/threonine kinase 1 Homo sapiens 95-98 35500642-12 2022 Thus, we conclude that astaxanthin protected the retinal cells from HG-induced inflammation by modulating the NF-kappaB through ROS-PI3K/Akt signaling cascade. ros 128-131 AKT serine/threonine kinase 1 Homo sapiens 137-140 34901534-6 2022 When HL-60 cells were treated by Au@Ce NPs, the removal of endogenous ROS signal significantly arrested cell cycle at G1 phase and suppressed the cell proliferation by blocking the mitogen-activated protein kinases (MAPKs) signaling and the Akt/Cyclin D1 cell cycle signaling. ros 70-73 AKT serine/threonine kinase 1 Homo sapiens 241-244 35525345-0 2022 Arsenic exposure elevated ROS promotes energy metabolic reprogramming with enhanced AKT-dependent HK2 expression. ros 26-29 AKT serine/threonine kinase 1 Homo sapiens 84-87 35525345-8 2022 Further studies showed accumulated ROS determined the metabolic reprogramming via activating AKT and then increasing HK2 expression. ros 35-38 AKT serine/threonine kinase 1 Homo sapiens 93-96 34387860-4 2021 Upon NLRP3 activation, AKT activity is inhibited by second stimulus-induced ROS. ros 76-79 AKT serine/threonine kinase 1 Homo sapiens 23-26 34337709-0 2021 MiR-124 affects the apoptosis of brain vascular endothelial cells and ROS production through regulating PI3K/AKT signaling pathway. ros 70-73 AKT serine/threonine kinase 1 Homo sapiens 109-112 35525345-10 2022 Taken together, our results indicated that ROS induced by low-dose arsenic exposure determined energy metabolic reprogramming and acted a critical regulator for AKT-dependent HK2 expression and aerobic glycolysis. ros 43-46 AKT serine/threonine kinase 1 Homo sapiens 161-164 35617999-13 2022 These events were dependent on TLR2/MyD88/TRAF6- and PI3K/Akt/NADPH oxidase/ROS-regulated NF-kappaB activation. ros 76-79 AKT serine/threonine kinase 1 Homo sapiens 58-61 35191133-0 2022 Glucosamine suppresses oxidative stress and induces protective autophagy in osteoblasts by blocking the ROS/Akt/mTOR signaling pathway. ros 104-107 AKT serine/threonine kinase 1 Homo sapiens 108-111 35573641-0 2022 Baicalin induces apoptosis and autophagy in human osteosarcoma cells by increasing ROS to inhibit PI3K/Akt/mTOR, ERK1/2 and beta-catenin signaling pathways. ros 83-86 AKT serine/threonine kinase 1 Homo sapiens 103-106 35278669-7 2022 ATRA also blocked autophagic flow by activating the AKT/mTOR pathway, leading to an excessive accumulation of ROS, which further activated the NLRP3 inflammasome. ros 110-113 AKT serine/threonine kinase 1 Homo sapiens 52-55 35450413-6 2022 In vitro studies further uncovered that chondrocytes cocultured with BMSCs in the direct contact coculture system upregulated Kindlin-2 expression and subsequently activated the PI3K/AKT signaling pathway, which not only increases Sox9 and Col2 expression but also restores mitochondrial membrane potential and reduces ROS levels and apoptosis under inflammatory conditions. ros 319-322 AKT serine/threonine kinase 1 Homo sapiens 183-186 35402865-2 2022 Here we show that intracellular Ca2+ ((Ca2+)i) and ROS signals generated by high glucose and cytokine-induced ER stress activate calcineurin (CN)/NFATc2 and PI3K/AKT to maintain beta-cell identity and function. ros 51-54 AKT serine/threonine kinase 1 Homo sapiens 162-165 33877317-0 2021 Purpurin, a anthraquinone induces ROS-mediated A549 lung cancer cell apoptosis via inhibition of PI3K/AKT and proliferation. ros 34-37 AKT serine/threonine kinase 1 Homo sapiens 102-105 35204104-8 2022 UVB-induced ROS production mediated Akt and mitogen activated protein kinases (MAPKs) pathways, including p38, ERK, and JNK. ros 12-15 AKT serine/threonine kinase 1 Homo sapiens 36-39 33964994-0 2021 CN-3 induces mitochondrial apoptosis in glioma via Ros-mediated PI3K/AKT pathway. ros 51-54 AKT serine/threonine kinase 1 Homo sapiens 69-72 33977107-8 2021 However, ROS inhibition effectively attenuated WIN-induced DNA damage and dysfunction of VEGF-AKT/FAK signal axis and eventually improved U251 cell proliferation, migration, and invasion. ros 9-12 AKT serine/threonine kinase 1 Homo sapiens 94-97 33859780-10 2021 ROS scavenger and the agonist of the PI3K/AKT pathway could reverse these results. ros 0-3 AKT serine/threonine kinase 1 Homo sapiens 42-45 33577944-8 2021 From the present study, we concluded that CSE exposure could elevate the intracellular ROS mainly from DUOX1 and 2, and the increased ROS led to the inactivation of PTEN, Trx-1 and Akt activation, eventually cause the occurrence of COPD, suggesting that PTEN is a potential target for new therapies in COPD. ros 134-137 AKT serine/threonine kinase 1 Homo sapiens 181-184 33577944-16 2021 In conclusion, CSE exposure could elevate the intracellular ROS mainly from DUOX1 and 2 to oxidize PTEN and Trx-1 resulting in Akt activation, eventually cause the occurrence of COPD, suggesting that PTEN is a potential target for new therapies in COPD. ros 60-63 AKT serine/threonine kinase 1 Homo sapiens 127-130 33376580-10 2020 Inhibition of ROS or HIF-1alpha also suppressed the activation of the Akt/mTOR pathway, which was implicated in H. pylori-induced macrophage polarization. ros 14-17 AKT serine/threonine kinase 1 Homo sapiens 70-73 33217539-0 2021 Eldecalcitol induces apoptosis and autophagy in human osteosarcoma MG-63 cells by accumulating ROS to suppress the PI3K/Akt/mTOR signaling pathway. ros 95-98 AKT serine/threonine kinase 1 Homo sapiens 120-123 33217539-11 2021 In conclusion, our results reveal that ED-71 induced G2/M arrest, apoptosis and autophagy in MG-63 cells by accumulating ROS to suppress the PI3K/Akt/mTOR signaling pathway. ros 121-124 AKT serine/threonine kinase 1 Homo sapiens 146-149 33486268-13 2021 CONCLUSION: Our results suggest that Daph triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. ros 51-54 AKT serine/threonine kinase 1 Homo sapiens 138-141 33397994-5 2021 IR-61 inhibits the classical activation of ATMs by increasing mitochondrial complex levels and oxidative phosphorylation via the ROS/Akt/Acly pathway. ros 129-132 AKT serine/threonine kinase 1 Homo sapiens 133-136 33097188-6 2020 In addition, GREM1 activated STAT3 transcription factor through the ROS-Akt signaling pathway. ros 68-71 AKT serine/threonine kinase 1 Homo sapiens 72-75 33780455-0 2021 CD44 modulates metabolic pathways and altered ROS-mediated Akt signal promoting cholangiocarcinoma progression. ros 46-49 AKT serine/threonine kinase 1 Homo sapiens 59-62 33527955-0 2021 The main anthocyanin monomer of Lycium ruthenicum Murray induces apoptosis through the ROS/PTEN/PI3K/Akt/caspase 3 signaling pathway in prostate cancer DU-145 cells. ros 87-90 AKT serine/threonine kinase 1 Homo sapiens 101-104 33503015-0 2021 Correction for: Taurine suppresses ROS-dependent autophagy via activating Akt/mTOR signaling pathway in calcium oxalate crystals-induced renal tubular epithelial cell injury. ros 35-38 AKT serine/threonine kinase 1 Homo sapiens 74-77 33376580-13 2020 Crosstalk between ROS and HIF-1alpha regulates H. pylori-induced macrophage polarization via the Akt/mTOR pathway. ros 18-21 AKT serine/threonine kinase 1 Homo sapiens 97-100 33035517-10 2020 Moreover, morusin treatment strikingly enhanced intracellular ROS level, an ROS scavenger NAC blocked cell death and changes of Akt, JNK and ERK induced by morusin. ros 76-79 AKT serine/threonine kinase 1 Homo sapiens 128-131 32768820-0 2020 Chlorpyrifos induces the apoptosis and necroptosis of L8824 cells through the ROS/PTEN/PI3K/AKT axis. ros 78-81 AKT serine/threonine kinase 1 Homo sapiens 92-95 33105741-8 2020 Resulting from HPbetaCD antioxidant and anticytotoxic potential and protective capacity against ROS-induced PI3K/Akt signaling and HDAC2 inhibition, BUD:HPbetaCD might be more beneficial than BUD alone in a context of concomitant oxidative and inflammatory stress. ros 96-99 AKT serine/threonine kinase 1 Homo sapiens 113-116 32687961-8 2020 Akt inhibition decreased UPM-induced ROS formation and p38 and p65 protein phosphorylation, and restored the decreased ZO-1 and E-cadherin expression. ros 37-40 AKT serine/threonine kinase 1 Homo sapiens 0-3 32738660-4 2020 We found that, compared to the non-biomimetic SeHANs, the B-SeHANs exhibited highly enhanced cellular internalization and intracellular degradation, and induced subsequent autophagy and caspase-dependent apoptosis via the ROS-mediated activation of the JNK pathway and inhibition of the Akt/mTOR pathway. ros 222-225 AKT serine/threonine kinase 1 Homo sapiens 287-290 32687844-0 2020 The vicious cycle between ferritinophagy and ROS production triggered EMT inhibition of gastric cancer cells was through p53/AKT/mTor pathway. ros 45-48 AKT serine/threonine kinase 1 Homo sapiens 125-128 32786113-11 2020 Moreover AOPPs activated the accumulated FOXO3a by maintaining FOXO3a in the nucleus, and this process was dependent on ROS-mediated AKT signaling deactivation. ros 120-123 AKT serine/threonine kinase 1 Homo sapiens 133-136 33059314-5 2020 Mechanistically, we demonstrate that deficiency of USF2 promotes survival by inducing mitophagy in a ROS-sensitive manner by activating both ERK1/2 and AKT. ros 101-104 AKT serine/threonine kinase 1 Homo sapiens 152-155 32931452-0 2020 Taurine suppresses ROS-dependent autophagy via activating Akt/mTOR signaling pathway in calcium oxalate crystals-induced renal tubular epithelial cell injury. ros 19-22 AKT serine/threonine kinase 1 Homo sapiens 58-61 32931452-11 2020 In summary, the current study shows that taurine inhibits ROS-dependent autophagy via activating Akt/mTOR signaling pathway in CaOx crystals-induced HK-2 cell and kidney injury, suggesting that taurine may serve as an effective therapeutic agent for the treatment of CaOx nephrolithiasis. ros 58-61 AKT serine/threonine kinase 1 Homo sapiens 97-100 32467587-9 2020 We observed that MGO-induced autophagic cell death and inhibited the ROS-mediated Akt/mTOR signaling pathway. ros 69-72 AKT serine/threonine kinase 1 Homo sapiens 82-85 32289613-7 2020 When combined with immunofluorescence, Western blot analysis, and real-time RT-PCR analysis, this data showed that the mitochondrial-ROS-driven feed-forward loop increased phospho-PDGFRalpha/beta, which stimulates apoptosis by suppressing the PI3K-Akt pathway. ros 133-136 AKT serine/threonine kinase 1 Homo sapiens 248-251 31987842-0 2020 Piperlongumine induces apoptosis and G2/M phase arrest in human osteosarcoma cells by regulating ROS/PI3K/Akt pathway. ros 97-100 AKT serine/threonine kinase 1 Homo sapiens 106-109 31987842-9 2020 Furthermore, we also found that piperlongumine significantly induced apoptosis and cell cycle arrest of osteosarcoma cells by regulating ROS/PI3K/Akt signaling pathway. ros 137-140 AKT serine/threonine kinase 1 Homo sapiens 146-149 31987842-11 2020 In addition, the underlying mechanism demonstrated that piperlongumine produced potent antitumor properties in osteosarcoma cells by regulating ROS/PI3K/Akt signaling pathway. ros 144-147 AKT serine/threonine kinase 1 Homo sapiens 153-156 32467587-11 2020 Collectively, these findings suggest that autophagy and apoptosis inhibit angiogenesis via the ROS-mediated Akt/mTOR and MAPKs signaling pathways, respectively, when HAoEC are treated with MGO. ros 95-98 AKT serine/threonine kinase 1 Homo sapiens 108-111 30920152-9 2019 In summary, our study demonstrates that PD synergised with 2-DG to enhance its anti-cancer efficacy by inhibiting the ROS/PI3K/AKT/HIF-1alpha/HK2 signalling axis, providing a potential anti-cancer strategy. ros 118-121 AKT serine/threonine kinase 1 Homo sapiens 127-130 32121588-1 2020 Mevastatin (MVS) has been previously shown to induce heme oxygenase (HO)-1 expression through Nox/ROS-dependent PDGFRalpha/PI3K/Akt/Nrf2/ARE axis in human pulmonary alveolar epithelial cells (HPAEpiCs). ros 98-101 AKT serine/threonine kinase 1 Homo sapiens 128-131 31494106-9 2019 Furthermore, FOXP1 overexpression significantly prevented HG-induced activation of Akt/mTOR signaling in MCs, and Akt activator blocked FOXP1-mediated cell proliferation, ROS production and ECM accumulation in MCs. ros 171-174 AKT serine/threonine kinase 1 Homo sapiens 114-117 31648639-7 2020 Furthermore, Ag@PTX enhanced the anti-canceractivity of A549 cells through ROS-mediated p53 and AKT signalling pathways. ros 75-78 AKT serine/threonine kinase 1 Homo sapiens 96-99 30767087-5 2019 ROS here played a crucial role in modulating Akt activity when autophagy process was hindered by chloroquine, excessive ROS accumulation in the cell inhibited Akt activity. ros 0-3 AKT serine/threonine kinase 1 Homo sapiens 45-48 30767087-5 2019 ROS here played a crucial role in modulating Akt activity when autophagy process was hindered by chloroquine, excessive ROS accumulation in the cell inhibited Akt activity. ros 0-3 AKT serine/threonine kinase 1 Homo sapiens 159-162 30767087-5 2019 ROS here played a crucial role in modulating Akt activity when autophagy process was hindered by chloroquine, excessive ROS accumulation in the cell inhibited Akt activity. ros 120-123 AKT serine/threonine kinase 1 Homo sapiens 45-48 30767087-5 2019 ROS here played a crucial role in modulating Akt activity when autophagy process was hindered by chloroquine, excessive ROS accumulation in the cell inhibited Akt activity. ros 120-123 AKT serine/threonine kinase 1 Homo sapiens 159-162 31068208-0 2019 Anti-EMT properties of CoQ0 attributed to PI3K/AKT/NFKB/MMP-9 signaling pathway through ROS-mediated apoptosis. ros 88-91 AKT serine/threonine kinase 1 Homo sapiens 47-50 30629695-0 2019 Retraction: Human Phosphatidylethanolamine-Binding Protein 4 Promoted the Radioresistance of Human Rectal Cancer by Activating Akt in an ROS-Dependent Way. ros 137-140 AKT serine/threonine kinase 1 Homo sapiens 127-130 30342220-7 2019 Together, inhibitions of PI3K/Akt and ERK and activation of p38 mediated the compounds-induced apoptosis through modulating the mitochondrial pathway and/or ROS production. ros 157-160 AKT serine/threonine kinase 1 Homo sapiens 30-33 30874538-0 2019 beta-Thujaplicin induces autophagic cell death, apoptosis, and cell cycle arrest through ROS-mediated Akt and p38/ERK MAPK signaling in human hepatocellular carcinoma. ros 89-92 AKT serine/threonine kinase 1 Homo sapiens 102-105 30874538-5 2019 Further using beta-Thujaplicin combined with an autophagy blocker or agonist treatment HepG2 cells, we found that beta-Thujaplicin induced autophagic cell death (ACD) mediated by ROS caused inhibition of the Akt-mTOR signaling pathway. ros 179-182 AKT serine/threonine kinase 1 Homo sapiens 208-211 31776986-4 2019 This section will focus on ROS-mediated regulation of autophagy through PI3K/Akt, AMPK, JNK, ERK, ATG4, and other pathways. ros 27-30 AKT serine/threonine kinase 1 Homo sapiens 77-80 30766661-6 2019 Moreover, TBBPA-induced activation of Akt/MAPK pathways and MMP-9 expression were attenuated by a specific NADPH oxidase inhibitor, and the ROS scavenger. ros 140-143 AKT serine/threonine kinase 1 Homo sapiens 38-41 30381241-10 2018 In conclusion: our data indicate that the increased vulnerability of the diabetic myocardium to I/R-induced apoptosis/dysfunction is attributable, in part, to decreased myocardial Sirt1 activity which leads to a decrease in Akt activation, an increase in Drp1 activity, culminating in excessive mitochondrial fission and ROS production. ros 321-324 AKT serine/threonine kinase 1 Homo sapiens 224-227 30145470-0 2018 4-Methylcatechol prevents streptozotocin-induced acute kidney injury through modulating NGF/TrkA and ROS-related Akt/GSK3beta/beta-catenin pathways. ros 101-104 AKT serine/threonine kinase 1 Homo sapiens 113-116 30265530-10 2018 Thus, the present study revealed that N-O reduction of cyadox and ROS-mediated AKT/FOXO1 and AKT/P53 pathways were involved in growth promotion and cytotoxicity of cyadox. ros 66-69 AKT serine/threonine kinase 1 Homo sapiens 79-82 30265530-10 2018 Thus, the present study revealed that N-O reduction of cyadox and ROS-mediated AKT/FOXO1 and AKT/P53 pathways were involved in growth promotion and cytotoxicity of cyadox. ros 66-69 AKT serine/threonine kinase 1 Homo sapiens 93-96 30564384-6 2018 Furthermore, Se@Ga enhanced the anti-cancer activity of HepG2 cells through ROS-mediated AKT and p38 signalling pathways. ros 76-79 AKT serine/threonine kinase 1 Homo sapiens 89-92 30265530-0 2018 N-O Reduction and ROS-Mediated AKT/FOXO1 and AKT/P53 Pathways Are Involved in Growth Promotion and Cytotoxicity of Cyadox. ros 18-21 AKT serine/threonine kinase 1 Homo sapiens 31-34 30265530-0 2018 N-O Reduction and ROS-Mediated AKT/FOXO1 and AKT/P53 Pathways Are Involved in Growth Promotion and Cytotoxicity of Cyadox. ros 18-21 AKT serine/threonine kinase 1 Homo sapiens 45-48 30410328-8 2018 Moreover, Au-Ag@PDA NPs decreased the expression of phosphorylated AKT and ERK and promoted the production of ROS that function upstream of apoptosis and autophagy. ros 110-113 AKT serine/threonine kinase 1 Homo sapiens 67-70 30213730-5 2018 In addition, ATO-treated U937 cells showed ROS-mediated inhibition of TET2 transcription, leading to downregulation of FOXP3 expression and in turn, suppression of FOXP3-mediated activation of Lyn and Akt. ros 43-46 AKT serine/threonine kinase 1 Homo sapiens 201-204 28912678-6 2017 These findings demonstrated that ROS might be located upstream of IL-17A and HMGB1 so that ROS can regulate HMGB1/IL-17A expression to affect the p53 and PI3K/Akt signaling pathways and therefore promote the occurrence of apoptosis in microglial cells. ros 33-36 AKT serine/threonine kinase 1 Homo sapiens 159-162 29898731-12 2018 PCa cells with mutated p53 (DU-145) and increased ROS showed significant reduction in the activation of pro-survival Akt pathway while Raf/MEK were activated in response to quercetin. ros 50-53 AKT serine/threonine kinase 1 Homo sapiens 117-120 29898731-13 2018 PC-3 cells lacking p53 and PTEN with reduced ROS levels showed significant activation of Akt and NF-kappaB pathway. ros 45-48 AKT serine/threonine kinase 1 Homo sapiens 89-92 29770114-10 2018 Furthermore, we found artocarpin-induced ROS production in mitochondria is associated with Akt- and ERK1/2 activation. ros 41-44 AKT serine/threonine kinase 1 Homo sapiens 91-94 29770114-11 2018 After treatment with artocarpin, ROS causes PI3K/Akt/ERK1/2-induced cell death of these tumor cells. ros 33-36 AKT serine/threonine kinase 1 Homo sapiens 49-52 28906145-4 2018 This was achieved by modulating MDA, GST, IL-1beta, IL-6 and reduced the interference of ROS with IGF-1 and NGF stimulating the PI3K/AKT-signaling. ros 89-92 AKT serine/threonine kinase 1 Homo sapiens 133-136 29331753-10 2018 The results show that the complex induces apoptosis through ROS-mediated mitochondria dysfunction and inhibition of AKT/mTOR pathways. ros 60-63 AKT serine/threonine kinase 1 Homo sapiens 116-119 30032136-14 2018 The metformin/FTY720 regimen markedly induced ROS generation; moreover, apoptosis, ER stress and inhibition of PI3K/AKT/ mTOR were attenuated by the ROS scavenger NAC. ros 149-152 AKT serine/threonine kinase 1 Homo sapiens 116-119 28430389-8 2017 The ROS generated by the combination of carmustine and selenite exhibited a strong inhibition on EGF stimulated EGFR and its downstream signaling molecules such as Akt, NF-kB, ERK1/2, and Cyclin D1. ros 4-7 AKT serine/threonine kinase 1 Homo sapiens 164-167 29299162-9 2017 CDDP-mediated intracellular ROS increment plays an important role in FOXO3-MUL1-AKT signal pathway. ros 28-31 AKT serine/threonine kinase 1 Homo sapiens 80-83 28959260-5 2017 Nrf2- or PKR/Akt-deficient macrophages exhibited increased levels of ROS/RNS and reduced expression of Sod1 Nrf2-dependent gene and reduced parasite load. ros 69-72 AKT serine/threonine kinase 1 Homo sapiens 13-16 29922854-0 2018 fMLP-dependent activation of Akt and ERK1/2 through ROS/Rho A pathways is mediated through restricted activation of the FPRL1 (FPR2) receptor. ros 52-55 AKT serine/threonine kinase 1 Homo sapiens 29-32 29922854-10 2018 CONCLUSION: Collectively, these data suggested that fMLP-activated ERK1/2 and Akt pathways through specific activation of the FPRL1/ROS/RoA-GTPase pathway. ros 132-135 AKT serine/threonine kinase 1 Homo sapiens 78-81 29589770-4 2018 Key requirement for the involvement of the redox modifications in RONS signalling including ROS-MAPK, ROS-PI3K/Akt, and RNS-TNF-alpha/NF-kB signalling is their specificity provided by a residue microenvironment and reaction kinetics. ros 102-105 AKT serine/threonine kinase 1 Homo sapiens 111-114 30317243-0 2018 High Glucose Induces VEGF-C Expression via the LPA1/3-Akt-ROS-LEDGF Signaling Axis in Human Prostate Cancer PC-3 Cells. ros 58-61 AKT serine/threonine kinase 1 Homo sapiens 54-57 29768267-0 2018 Type 2 Diabetes Promotes Cell Centrosome Amplification via AKT-ROS-Dependent Signalling of ROCK1 and 14-3-3sigma. ros 63-66 AKT serine/threonine kinase 1 Homo sapiens 59-62 29768267-12 2018 Results from further analyses showed that AKT-ROS-dependent upregulations of expression, binding and centrosome translocation of ROCK1 and 14-3-3sigma was the molecular pathway underlying the centrosome amplification in vitro triggered by high glucose, insulin and palmitic acid. ros 46-49 AKT serine/threonine kinase 1 Homo sapiens 42-45 29768267-14 2018 CONCLUSION: Our results show that type 2 diabetes promotes cell centrosome amplification, and suggest that the diabetic pathophysiological factors-activated AKT-ROS-dependent signalling of ROCK1 and 14-3-3sigma is the underlying molecular mechanism. ros 161-164 AKT serine/threonine kinase 1 Homo sapiens 157-160 29111231-0 2017 ROS-AKT-mTOR axis mediates autophagy of human umbilical vein endothelial cells induced by cooking oil fumes-derived fine particulate matters in vitro. ros 0-3 AKT serine/threonine kinase 1 Homo sapiens 4-7 29111231-11 2017 These findings demonstrate ROS-AKT-mTOR axis plays a critical role in HUVECs autophagy induced by COFs-derived PM2.5. ros 27-30 AKT serine/threonine kinase 1 Homo sapiens 31-34 28912678-6 2017 These findings demonstrated that ROS might be located upstream of IL-17A and HMGB1 so that ROS can regulate HMGB1/IL-17A expression to affect the p53 and PI3K/Akt signaling pathways and therefore promote the occurrence of apoptosis in microglial cells. ros 91-94 AKT serine/threonine kinase 1 Homo sapiens 159-162 28536473-9 2017 Moreover, AMC provoked the production of ROS, H2O2, and NO, modulating the PI3K/Akt, MAPK, NFkappaB and Nrf2 pathways and their downstream transcriptional cascades, ultimately evoked oxidative stress and apoptosis in HpeG2 cells. ros 41-44 AKT serine/threonine kinase 1 Homo sapiens 80-83 29088809-5 2017 Further, we found the elevated miR-149 expression by BPIS-induced ROS accumulation, directly targeted the Akt expression to block NF-kappaB nuclear translocation. ros 66-69 AKT serine/threonine kinase 1 Homo sapiens 106-109 28440462-0 2017 Imperatorin efficiently blocks TNF-alpha-mediated activation of ROS/PI3K/Akt/NF-kappaB pathway. ros 64-67 AKT serine/threonine kinase 1 Homo sapiens 73-76 28440462-7 2017 Taken together, imperatorin can blunt inflammation by inhibiting the ROS-mediated activation of the PI3K/Akt/NF-kappaB pathway. ros 69-72 AKT serine/threonine kinase 1 Homo sapiens 105-108 28407774-0 2017 ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway. ros 0-3 AKT serine/threonine kinase 1 Homo sapiens 66-69 28255993-0 2017 Curcuminoid EF24 enhances the anti-tumour activity of Akt inhibitor MK-2206 through ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction in gastric cancer. ros 84-87 AKT serine/threonine kinase 1 Homo sapiens 54-57 28255993-12 2017 CONCLUSION AND IMPLICATIONS: Targeting ROS generation by using a combination of an Akt inhibitor and EF24 could have potential as a therapy for gastric cancer. ros 39-42 AKT serine/threonine kinase 1 Homo sapiens 83-86 28407774-8 2017 Here, we highlight the cross-talk between AMPK and AKT and their regulation on ROS production and elimination, which summarizes the mechanism of cancer cell adaptability under ROS stress and suggests potential options for cancer therapeutics. ros 79-82 AKT serine/threonine kinase 1 Homo sapiens 51-54 28407774-8 2017 Here, we highlight the cross-talk between AMPK and AKT and their regulation on ROS production and elimination, which summarizes the mechanism of cancer cell adaptability under ROS stress and suggests potential options for cancer therapeutics. ros 176-179 AKT serine/threonine kinase 1 Homo sapiens 51-54 28139737-6 2017 These results establish a novel mechanism by which NF-kappaB and Akt contribute to chemoresistance involving a signaling pathway consisting of histone H4, DNA-PK, RIP1 and IAPs that attenuates ROS-mediated apoptosis, and targeting this pathway may improve the anticancer efficacy of platinum-based chemotherapy. ros 193-196 AKT serine/threonine kinase 1 Homo sapiens 65-68 28065785-5 2017 Furthermore, PI3K/AKT/HIF-1alpha signaling pathway is involved in ROS-mediated Mxi1-0 and VEGF expression in hypoxic HepG2 cells. ros 66-69 AKT serine/threonine kinase 1 Homo sapiens 18-21 28065785-7 2017 Taken together, this study demonstrate a positive regulatory feedback loop in which ROS mediates hypoxia-induced Mxi1-0 via activation of PI3K/AKT/HIF-1alpha pathway, events that in turn elevate ROS generation and promote hypoxia-induced VEGF expression. ros 84-87 AKT serine/threonine kinase 1 Homo sapiens 143-146 28065785-7 2017 Taken together, this study demonstrate a positive regulatory feedback loop in which ROS mediates hypoxia-induced Mxi1-0 via activation of PI3K/AKT/HIF-1alpha pathway, events that in turn elevate ROS generation and promote hypoxia-induced VEGF expression. ros 195-198 AKT serine/threonine kinase 1 Homo sapiens 143-146 27654302-7 2017 Meanwhile, fucoidan treatment increased the generation of intracellular ROS, whereas the over-elimination of ROS by N-acetylcysteine, an anti-oxidant, attenuated fucoidan-induced apoptosis, inhibition of hTERT, c-myc, and Sp1 expression, and reversed fucoidan-induced inactivation of the PI3K/Akt signaling pathway. ros 109-112 AKT serine/threonine kinase 1 Homo sapiens 293-296 27654302-8 2017 Collectively, these data indicate that the induction of apoptosis and the inhibition of telomerase activity by fucoidan are mediated via ROS-dependent inactivation of the PI3K/Akt pathway. ros 137-140 AKT serine/threonine kinase 1 Homo sapiens 176-179 28350337-0 2017 3,4-Dihydroxybenzalactone Suppresses Human Non-Small Cell Lung Carcinoma Cells Metastasis via Suppression of Epithelial to Mesenchymal Transition, ROS-Mediated PI3K/AKT/MAPK/MMP and NFkappaB Signaling Pathways. ros 147-150 AKT serine/threonine kinase 1 Homo sapiens 165-168 27746262-0 2016 Caffeic acid phenethyl ester alleviates asthma by regulating the airway microenvironment via the ROS-responsive MAPK/Akt pathway. ros 97-100 AKT serine/threonine kinase 1 Homo sapiens 117-120 28883885-7 2017 Moreover, sequential activation of ROS-dependent phosphor-Akt expression was dose-dependently inhibited by the combinational application of BA and Ptx, which was more significantly effective than the single treatment of either BA or Ptx. ros 35-38 AKT serine/threonine kinase 1 Homo sapiens 58-61 27746262-10 2016 The phosphorylation of Akt and Mitogen-Activated Protein Kinase (MAPK) caused by increased ROS was significantly decreased by CAPE, which implied a contribution of ROS-MAPK/Akt signaling to the attenuation of asthma. ros 164-167 AKT serine/threonine kinase 1 Homo sapiens 23-26 27746262-10 2016 The phosphorylation of Akt and Mitogen-Activated Protein Kinase (MAPK) caused by increased ROS was significantly decreased by CAPE, which implied a contribution of ROS-MAPK/Akt signaling to the attenuation of asthma. ros 164-167 AKT serine/threonine kinase 1 Homo sapiens 173-176 27825816-0 2016 Corrigendum to "Caffeic acid phenethyl ester alleviates asthma by regulating the airway microenvironment via the ROS-responsive MAPK/Akt pathway" [Free Radic. ros 113-116 AKT serine/threonine kinase 1 Homo sapiens 133-136 27746262-10 2016 The phosphorylation of Akt and Mitogen-Activated Protein Kinase (MAPK) caused by increased ROS was significantly decreased by CAPE, which implied a contribution of ROS-MAPK/Akt signaling to the attenuation of asthma. ros 91-94 AKT serine/threonine kinase 1 Homo sapiens 23-26 27746262-10 2016 The phosphorylation of Akt and Mitogen-Activated Protein Kinase (MAPK) caused by increased ROS was significantly decreased by CAPE, which implied a contribution of ROS-MAPK/Akt signaling to the attenuation of asthma. ros 91-94 AKT serine/threonine kinase 1 Homo sapiens 173-176 26942697-0 2016 Repeated PM2.5 exposure inhibits BEAS-2B cell P53 expression through ROS-Akt-DNMT3B pathway-mediated promoter hypermethylation. ros 69-72 AKT serine/threonine kinase 1 Homo sapiens 73-76 27659528-0 2016 Geridonin and paclitaxel act synergistically to inhibit the proliferation of gastric cancer cells through ROS-mediated regulation of the PTEN/PI3K/Akt pathway. ros 106-109 AKT serine/threonine kinase 1 Homo sapiens 147-150 27687768-8 2016 These results indicate that Ang-(1-7) antagonizes the Ang II-induced VSMC proliferation, migration and inflammation through activation of Mas receptor and then suppression of ROS-dependent PI3K/Akt and MAPK/ERK signaling pathways. ros 175-178 AKT serine/threonine kinase 1 Homo sapiens 194-197 27773814-8 2016 In conclusion, our data suggest that Sirt3 overexpression antagonize high glucose-induced apoptosis by controlling ROS accumulation and ROS-sensitive Akt/FoxO signaling pathway in HK-2 cells. ros 136-139 AKT serine/threonine kinase 1 Homo sapiens 150-153 27740938-9 2016 7-KC further induced intracellular ROS production as shown by increase in DCF fluorescence and Akt phosphorylation. ros 35-38 AKT serine/threonine kinase 1 Homo sapiens 95-98 27697723-10 2016 Taken together, our study demonstrates that the inhibitory effect of SZC015 against H322 cells is mediated by excessive ROS generation that could suppress Akt/NF-kappaB signaling pathway, which thereby leads to apoptotic and autophagic cell death. ros 120-123 AKT serine/threonine kinase 1 Homo sapiens 155-158 27687768-0 2016 Angiotensin-(1-7) abrogates angiotensin II-induced proliferation, migration and inflammation in VSMCs through inactivation of ROS-mediated PI3K/Akt and MAPK/ERK signaling pathways. ros 126-129 AKT serine/threonine kinase 1 Homo sapiens 144-147 26942697-7 2016 Furthermore, ROS-induced activation of Akt was involved in PM2.5-induced increase in DNMT3B. ros 13-16 AKT serine/threonine kinase 1 Homo sapiens 39-42 26942697-8 2016 In conclusion, our results strongly suggest that repeated exposure to PM2.5 induces epigenetic silencing of P53 through ROS-Akt-DNMT3B pathway-mediated promoter hypermethylation, which not only provides a possible explanation for PM-induced lung cancer, but also may help to identify specific interventions to prevent PM-induced lung carcinogenesis. ros 120-123 AKT serine/threonine kinase 1 Homo sapiens 124-127 26689473-3 2016 We recently showed that relatively low concentrations of 27-OH generated a strong survival signaling through an early and transient increase of cellular ROS level, that enhanced MEK-ERK/PI3K-Akt phosphorylation, in turn responsible of a sustained quenching of ROS production. ros 153-156 AKT serine/threonine kinase 1 Homo sapiens 191-194 26612416-8 2016 Moreover, Se@LDH-pooled siRNAs could induce cell apoptosis, change cell morphology and increase cellular ROS levels through change the expression of Bcl-2/Bax, activation of caspase-3, PI3K/AKT/mTOR and MAPK/ERK pathways. ros 105-108 AKT serine/threonine kinase 1 Homo sapiens 190-193 26689473-3 2016 We recently showed that relatively low concentrations of 27-OH generated a strong survival signaling through an early and transient increase of cellular ROS level, that enhanced MEK-ERK/PI3K-Akt phosphorylation, in turn responsible of a sustained quenching of ROS production. ros 260-263 AKT serine/threonine kinase 1 Homo sapiens 191-194 26689473-4 2016 It remains to identify the link between ERK/Akt up-regulation and the consequent quenching effect on ROS intracellular level that efficiently and markedly delay the pro-apoptotic effect of the oxysterol. ros 101-104 AKT serine/threonine kinase 1 Homo sapiens 44-47 26507802-4 2016 H-RuBmp demonstrated a higher interaction potency with the cell membrane and induced higher levels of ROS overproduction in cancer cells to regulate the AKT, MAPK, and p53 signaling pathways. ros 102-105 AKT serine/threonine kinase 1 Homo sapiens 153-156 26707081-6 2016 Governed by Akt, the consequent inhibition of ROS formation and oxidative stress preserved the AD mode of stem cells, which is critical for an improved radiotherapy response in clinical treatment, as the tumor group is thus easier to eliminate with radiation therapy. ros 46-49 AKT serine/threonine kinase 1 Homo sapiens 12-15 29227594-3 2016 Our previousstudies revealed that ROS production by human colorectal adenocarcinoma HT-29 cells is positively correlatedwith adaptor protein Ruk/CIN85 expression while increased levels of Ruk/CIN85 in weakly invasive humanbreast adenocarcinoma MC F-7 cells contribute to their malignant phenotype through the constitutiveactivation of Src/Akt pathway. ros 34-37 AKT serine/threonine kinase 1 Homo sapiens 339-342 27310130-6 2016 In addition, exposing cells to MF increased the level of mitochondrial ROS which were released into cytoplasm through mitochondrial permeability transition pores (mPTP), and induced ROS-dependent phosphorylation of Akt. ros 182-185 AKT serine/threonine kinase 1 Homo sapiens 215-218 26632198-0 2015 EZH2 phosphorylation regulates Tat-induced HIV-1 transactivation via ROS/Akt signaling pathway. ros 69-72 AKT serine/threonine kinase 1 Homo sapiens 73-76 26632198-6 2015 Our study reveals that novel mechanisms allow Tat-induced HIV-1 transactivation by ROS/Akt-dependent downregulating the EZH2 epigenetic silencing machinery. ros 83-86 AKT serine/threonine kinase 1 Homo sapiens 87-90 26632198-5 2015 ROS/Akt-dependent p-EZH2 was correlated with Tat-induced transactivation. ros 0-3 AKT serine/threonine kinase 1 Homo sapiens 4-7 26465677-0 2015 A Novel Platinum-Maurocalcine Conjugate Induces Apoptosis of Human Glioblastoma Cells by Acting through the ROS-ERK/AKT-p53 Pathway. ros 108-111 AKT serine/threonine kinase 1 Homo sapiens 116-119 26514923-11 2015 These results demonstrated that Cd induces MMP-9 expression via ROS-dependent EGFR->Erk1/2, JNK1/2->AP-1 and EGFR->Akt->NF-kappaB signaling pathways and, in turn, stimulates invasiveness in human endothelial cells. ros 64-67 AKT serine/threonine kinase 1 Homo sapiens 124-127 26634216-10 2015 We showed that IL-8 release induced by fMLP is dependent on NADPH oxidase, and ROS could play a redundant role in cell signalling, ultimately activating the PI3K/Akt and NF-kappaB pathways in neutrophils. ros 79-82 AKT serine/threonine kinase 1 Homo sapiens 162-165 26450902-5 2015 We also showed that MUL1 inhibited the level of AKT and p-AKT and MUL1 expression was increased by NTP-induced ROS. ros 111-114 AKT serine/threonine kinase 1 Homo sapiens 58-61 26107995-7 2015 Interestingly, RuPOP@MWCNTs significantly enhanced the anticancer efficacy of clinically used X-ray against R-HepG2 cells through induction of apoptosis and G0/G1 cell cycle arrest, with the involvement of ROS overproduction, which activated several downstream signaling pathways, including DNA damage-mediated p53 phosphorylation, activation of p38, and inactivation of AKT and ERK. ros 206-209 AKT serine/threonine kinase 1 Homo sapiens 371-374 25305377-0 2014 Abrus precatorius agglutinin-derived peptides induce ROS-dependent mitochondrial apoptosis through JNK and Akt/P38/P53 pathways in HeLa cells. ros 53-56 AKT serine/threonine kinase 1 Homo sapiens 107-110 25072752-8 2014 ROS production was increased after DHMEQ-Olaparib treatment of Hep3B, which caused DNA damage by an accumulation of gammaH2AX, increased AKT phosphorylation and reduced cell viability. ros 0-3 AKT serine/threonine kinase 1 Homo sapiens 137-140 25135223-8 2014 Excessive ROS triggered DNA damage and activated downstream signaling pathways, including the phosphorylation of p53 and p38MAPK, and down-regulation of phosphorylated AKT and ERK, finally resulted in increase of radiosensitivity and inhibition of tumor reproduction. ros 10-13 AKT serine/threonine kinase 1 Homo sapiens 168-171 25942647-6 2015 This review summarizes the molecular mechanisms underlying the cross-talk between Rac and PI3K signaling in 2 different processes, cell migration and ROS production. ros 150-153 AKT serine/threonine kinase 1 Homo sapiens 82-85 25305377-7 2014 ROS further led to symptoms of early apoptosis by deregulating Akt (Protein Kinase B) and activating c-Jun N-terminal Kinase (JNK), p38 Mitogen Activated Protein Kinase (MAPK), p53, and autophagy starting from ~8h of incubation. ros 0-3 AKT serine/threonine kinase 1 Homo sapiens 63-66 24792722-8 2014 These results suggest that betaPix phosphorylation at Ser-340 upregulates Nox1 through Rac activation, confirming Rac as a trigger for acute Nox1-dependent ROS production. ros 156-159 AKT serine/threonine kinase 1 Homo sapiens 114-117 24992302-6 2014 Moreover, ROS was involved in POL-induced inhibition of Akt expression, and might therefore mediate both apoptosis and autophagy in A549 cells. ros 10-13 AKT serine/threonine kinase 1 Homo sapiens 56-59 24113182-12 2013 Thus, TAK1 deficiency in metastatic cancer cells increases integrin:Rac-induced ROS, which negatively regulated Rho by LMW-PTP to accelerate EMT. ros 80-83 AKT serine/threonine kinase 1 Homo sapiens 68-71 24032351-5 2013 Our observations in tissue bath studies were confirmed by Western blotting; 2,3-cis-procyanidins induced phosphorylation of eNOS and Akt in a ROS-dependent manner. ros 142-145 AKT serine/threonine kinase 1 Homo sapiens 133-136 24068521-8 2014 ROS inhibitor NAC abrogated the inhibitory effect of Hispidulin on P13k/Akt signalling pathway and the proapoptotic effect in HepG2 cells. ros 0-3 AKT serine/threonine kinase 1 Homo sapiens 72-75 24594691-0 2014 Human phosphatidylethanolamine-binding protein 4 promoted the radioresistance of human rectal cancer by activating Akt in an ROS-dependent way. ros 125-128 AKT serine/threonine kinase 1 Homo sapiens 115-118 24594691-6 2014 Western blot showed hPEBP4 could increase the radiation-induced Akt activation, for which reactive oxygen specimen(ROS) was required. ros 115-118 AKT serine/threonine kinase 1 Homo sapiens 64-67 23353183-3 2013 Of the MAP kinases, ERK or p38/JNK were phosphorylated earlier during curcumin treatment, and were responsible for curcumin-induced cell survival at early time of treatment with the help of phosphorylated Akt, while significant amounts of ROS production in later periods stimulated cell death with caspase degradation. ros 239-242 AKT serine/threonine kinase 1 Homo sapiens 205-208 19939451-4 2010 Especially, Rac-associated ROS-dependent MAP kinases, including ERK1/2 and p38, are involved in MHC class II-associated negative signal transduction in the phorbol 12, 13-dibutyrate (PDBU)-treated, but not LPS-treated, resting B cell line, 38B9. ros 27-30 AKT serine/threonine kinase 1 Homo sapiens 12-15 23252827-4 2013 Furthermore, inhibition of the miR-183/96/182 cluster induced ROS-mediated AKT/survival independent of three target genes FGF9, CPEB1, and FOXO1, and inhibition of the miRNA cluster induced p53/apoptosis signaling, which was dependent on these same genes. ros 62-65 AKT serine/threonine kinase 1 Homo sapiens 75-78 23063593-8 2013 These findings provide evidences that HER induces HepG2 apoptosis in a ROS-mediated mitochondria-dependent manner that correlate with the inactivation of the PI3K/Akt pathway. ros 71-74 AKT serine/threonine kinase 1 Homo sapiens 163-166 22895800-0 2012 Involvement of ROS in the inhibitory effect of thermotherapy combined with chemotherapy on A549 human lung adenocarcinoma cell growth through the Akt pathway. ros 15-18 AKT serine/threonine kinase 1 Homo sapiens 158-161 23284736-9 2012 The present results show that this ancient herbal decoction benefits endothelial function through increased activity of Akt kinase and eNOS; this effect is causally via a rise of intracellular Ca(2+) and a reduction of ROS. ros 219-222 AKT serine/threonine kinase 1 Homo sapiens 120-123 21837363-12 2011 Taken together, these findings demonstrate that activation of Akt, followed by GSK3beta inhibition and Bcl-2, Bcl-XL up-regulation and decrease of ROS generation, along with a synergistic effect of Rb down-regulation may cause apoptosis resistance, contributing to the overall mechanism of nickel carcinogenesis. ros 147-150 AKT serine/threonine kinase 1 Homo sapiens 62-65 21620957-0 2011 ROS-activated p38 MAPK/ERK-Akt cascade plays a central role in palmitic acid-stimulated hepatocyte proliferation. ros 0-3 AKT serine/threonine kinase 1 Homo sapiens 27-30 21620957-6 2011 The employment of several inhibitors and antioxidants indicates that a ROS-induced stress-sensitive p38 MAPK/ERK-Akt cascade plays a critical role in the regulation of PA on cell cycle and cell proliferation. ros 71-74 AKT serine/threonine kinase 1 Homo sapiens 113-116 21620957-7 2011 Moreover, PA dose and time dependently activates Nrf2 and this activation relies on ROS-induced stimulation of p38 MAPK/ERK-Akt signaling, demonstrating that Nrf2 activation may be associated with the regulation of PA on cell cycle transition and proliferation. ros 84-87 AKT serine/threonine kinase 1 Homo sapiens 124-127 21620957-8 2011 In conclusion, our study elucidates the importance of PA metabolism on cell proliferation, and suggests that PA stimulates hepatocyte proliferation through activating the ROS-p38 MAPK/ERK-Akt cascade which is intersected with the activation of Nrf2 and that the effect of ROS on signal transduction is in a dose- and time-dependent manner. ros 171-174 AKT serine/threonine kinase 1 Homo sapiens 188-191 21132068-4 2010 In contrast, the addition of HMG sensitizes LNCaP or PC3 prostate cancer cells harboring an active Akt to apoptosis, in which ROS is upregulated to induce the UPR and GADD153 expression. ros 126-129 AKT serine/threonine kinase 1 Homo sapiens 99-102 22251375-9 2012 CONCLUSION: From these results, we conclude that JEV activates the ROS/c-Src/PDGFR/PI3K/Akt/MAPKs pathway, which in turn triggers AP-1 activation and ultimately induces MMP-9 expression in RBA-1 cells. ros 67-70 AKT serine/threonine kinase 1 Homo sapiens 88-91 23554696-7 2011 Interestingly, EGF could induce a significant production of ROS, and N-acetyl-L-cysteine, a scavenger of ROS which abolished the EGF-induced ROS generation, cell migration, as well as activation of PI3K/Akt and PAK, but not Rac1. ros 105-108 AKT serine/threonine kinase 1 Homo sapiens 203-206 23554696-7 2011 Interestingly, EGF could induce a significant production of ROS, and N-acetyl-L-cysteine, a scavenger of ROS which abolished the EGF-induced ROS generation, cell migration, as well as activation of PI3K/Akt and PAK, but not Rac1. ros 105-108 AKT serine/threonine kinase 1 Homo sapiens 203-206 21123941-7 2011 Accumulation of unrepaired DNA following XPC silencing increased DNA-dependent protein kinase activity, which subsequently activated AKT1 and NADPH oxidase-1 (NOX1), resulting in ROS production and accumulation of specific deletions in mitochondrial DNA (mtDNA) over time. ros 179-182 AKT serine/threonine kinase 1 Homo sapiens 133-137 21123941-10 2011 Our results demonstrate that genomic instability resulting from XPC silencing results in activation of AKT1 and subsequently NOX1 to induce ROS generation, mtDNA deletions, and neoplastic transformation in human keratinocytes. ros 140-143 AKT serine/threonine kinase 1 Homo sapiens 103-107 19939451-7 2010 Collectively, Rac/ROS-related PKC and PI3K signaling are involved in a negative regulation cascade through the cross-linking of MHC class II molecules by anti-MHC class II antibodies in resting B cells. ros 18-21 AKT serine/threonine kinase 1 Homo sapiens 14-17 18830414-7 2008 Accordingly, both CK2 inhibitors and ROS scavengers restored PTEN activity and impaired PI3K/Akt signaling in T-ALL cells. ros 37-40 AKT serine/threonine kinase 1 Homo sapiens 93-96 19482076-0 2009 ROS-driven Akt dephosphorylation at Ser-473 is involved in 4-HPR-mediated apoptosis in NB4 cells. ros 0-3 AKT serine/threonine kinase 1 Homo sapiens 11-14 19482076-5 2009 These observations implicate the direct interaction between Akt and ROS. ros 68-71 AKT serine/threonine kinase 1 Homo sapiens 60-63 19482076-6 2009 Our data also reveal that 4-HPR-mediated ROS evoke Akt conformational change by forming an intramolecular disulfide bond; N-acetylcysteine and glutathione, as thiol antioxidants, significantly abate the ROS generation in 4-HPR-exposed cells. ros 41-44 AKT serine/threonine kinase 1 Homo sapiens 51-54 19482076-6 2009 Our data also reveal that 4-HPR-mediated ROS evoke Akt conformational change by forming an intramolecular disulfide bond; N-acetylcysteine and glutathione, as thiol antioxidants, significantly abate the ROS generation in 4-HPR-exposed cells. ros 203-206 AKT serine/threonine kinase 1 Homo sapiens 51-54 19482076-8 2009 All these results collectively suggest that 4-HPR-induced apoptosis is associated with a ROS-mediated conformational change in Akt, and this change, as a consequence, mediates dephosphorylation of Akt via regulating Akt-Hsp90 or Akt-PP2A complex formation. ros 89-92 AKT serine/threonine kinase 1 Homo sapiens 127-130 19482076-8 2009 All these results collectively suggest that 4-HPR-induced apoptosis is associated with a ROS-mediated conformational change in Akt, and this change, as a consequence, mediates dephosphorylation of Akt via regulating Akt-Hsp90 or Akt-PP2A complex formation. ros 89-92 AKT serine/threonine kinase 1 Homo sapiens 197-200 19482076-8 2009 All these results collectively suggest that 4-HPR-induced apoptosis is associated with a ROS-mediated conformational change in Akt, and this change, as a consequence, mediates dephosphorylation of Akt via regulating Akt-Hsp90 or Akt-PP2A complex formation. ros 89-92 AKT serine/threonine kinase 1 Homo sapiens 197-200 19482076-8 2009 All these results collectively suggest that 4-HPR-induced apoptosis is associated with a ROS-mediated conformational change in Akt, and this change, as a consequence, mediates dephosphorylation of Akt via regulating Akt-Hsp90 or Akt-PP2A complex formation. ros 89-92 AKT serine/threonine kinase 1 Homo sapiens 197-200 16885344-6 2006 We show that this FIG-ROS-mediated tumor formation in vivo parallels the activation of the tyrosine phosphatase SH2 domain-containing phosphatase-2 (SHP-2) and a phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling axis in tumors and tumor-derived cell lines. ros 22-25 AKT serine/threonine kinase 1 Homo sapiens 192-195 18239155-13 2008 CONCLUSIONS: PARP-1 inhibition prevents ROS- and RNS-induced HUVEC death by maintaining cellular energy in the form of NAD(+) and ATP, and also by activating a survival pathway via VEGFR2, Akt, and BAD phosphorylation. ros 40-43 AKT serine/threonine kinase 1 Homo sapiens 189-192 17573344-7 2007 The inhibition of PKC further augments Akt activity, which in turn induces ROS production and the accumulation of unfolded proteins in the endoplasmic reticulum, resulting in cell death. ros 75-78 AKT serine/threonine kinase 1 Homo sapiens 39-42 17318262-8 2007 First, Akt may stabilize cells with extensive mitochondrial DNA mutation, which can generate ROS. ros 93-96 AKT serine/threonine kinase 1 Homo sapiens 7-10 17318262-9 2007 Second, Akt can induce expression of the ROS-generating enzyme NOX4. ros 41-44 AKT serine/threonine kinase 1 Homo sapiens 8-11 16282349-12 2006 These data suggest that the G-CSF-induced Lyn-PI3K-Akt pathway drives ROS production. ros 70-73 AKT serine/threonine kinase 1 Homo sapiens 51-54 16282349-13 2006 One beneficial effect of therapeutic targeting of Lyn-PI3K-kinase-Akt cascade is abrogating ROS production. ros 92-95 AKT serine/threonine kinase 1 Homo sapiens 66-69 16282349-3 2006 G-CSF stimulation showed a time- and dose-dependent increase in ROS production, correlating with activation of Lyn and Akt. ros 64-67 AKT serine/threonine kinase 1 Homo sapiens 119-122 16282349-4 2006 Inhibition of Lyn, PI3-kinase, and Akt abrogated G-CSF-induced ROS production. ros 63-66 AKT serine/threonine kinase 1 Homo sapiens 35-38 12614848-5 2003 Reducing reagents/reactive oxygen species (ROS) scavengers reduced arsenite-induced Akt phosphorylation and beta cyclodextrin reduced arsenite-mediated ROS production, suggesting that arsenite-induced G-protein/Akt/GSK3beta pathway is membrane raft dependent and redox linked. ros 43-46 AKT serine/threonine kinase 1 Homo sapiens 84-87