PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29929000-0	2018	Telmisartan generates ROS-dependent upregulation of death receptor 5 to sensitize TRAIL in lung cancer via inhibition of autophagy flux.	ros	22-25	TNF receptor superfamily member 10b	Homo sapiens	52-68	
35616096-4	2022	CPT MV could produce ROS in the targeted cells upon laser irradiation to improve death receptor (DR)-5 expression and trigger Cyt c release from mitochondria.	ros	21-24	TNF receptor superfamily member 10b	Homo sapiens	81-102	
33676890-0	2021	Citrus-derived DHCP inhibits mitochondrial complex II to enhance TRAIL sensitivity via ROS-induced DR5 upregulation.	ros	87-90	TNF receptor superfamily member 10b	Homo sapiens	99-102	
33676890-7	2021	ROS significantly increase the expression of TRAIL death receptor 5 (DR5) via the p53 and C/EBP homologous protein pathways.	ros	0-3	TNF receptor superfamily member 10b	Homo sapiens	69-72	
34681736-5	2021	ROS-induced endoplasmic reticulum (ER) stress by OSMI-1 not only upregulated CHOP-DR5 signaling but also activated Jun-N-terminal kinase (JNK), resulting in a decrease in Bcl2 and the release of cytochrome c from mitochondria.	ros	0-3	TNF receptor superfamily member 10b	Homo sapiens	82-85	
29929000-6	2018	The molecular mechanism includes the blocking of AMPK phosphorylation causes inhibition of autophagy flux by telmisartan resulting in ROS generation leading to death receptor (DR5) upregulation and subsequent activation of the caspase cascade by TRAIL treatment.	ros	134-137	TNF receptor superfamily member 10b	Homo sapiens	176-179	
29929000-7	2018	Furthermore, using chloroquine and siATG5 significantly enhances ROS production and application of the ROS scavenger N-acetyl-cysteine (NAC) rescues the cells undergoing apoptosis by abrogating the expression of DR5 and finally the caspase cascade.	ros	103-106	TNF receptor superfamily member 10b	Homo sapiens	212-215	
28571773-0	2017	DATS sensitizes glioma cells to TRAIL-mediated apoptosis by up-regulation of death receptor 5 via ROS.	ros	98-101	TNF receptor superfamily member 10b	Homo sapiens	77-93	
28571773-6	2017	In addition, DATS enhances TRAIL-induced apoptosis through the downregulation of anti-apoptotic protein (Mcl-1) and the upregulation of DR5 receptors through actions on the ROS- induced-p53.	ros	173-176	TNF receptor superfamily member 10b	Homo sapiens	136-139	
25321472-9	2014	In conclusion, our results suggest that Med sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the upregulation of DR5 through activation of the ROS-JNK-CHOP pathway.	ros	163-166	TNF receptor superfamily member 10b	Homo sapiens	133-136	
26203587-16	2015	Taken together, these data suggest that TIIA enhances TRAIL-induced apoptosis by upregulating DR5 receptors through the ROS-JNK-CHOP signaling axis in human ovarian carcinoma cells.	ros	120-123	TNF receptor superfamily member 10b	Homo sapiens	94-97	
25320841-7	2014	Furthermore, DR5 expression induced by 1 was mediated via a ROS-independent pathway that required CHOP and p53.	ros	60-63	TNF receptor superfamily member 10b	Homo sapiens	13-16	
25320841-8	2014	Overall, these findings provide evidence that 1 potentiates TRAIL-mediated apoptosis through up-regulation of DR5 via a ROS-independent pathway.	ros	120-123	TNF receptor superfamily member 10b	Homo sapiens	110-113	
21854768-0	2011	Acrolein sensitizes human renal cancer Caki cells to TRAIL-induced apoptosis via ROS-mediated up-regulation of death receptor-5 (DR5) and down-regulation of Bcl-2.	ros	81-84	TNF receptor superfamily member 10b	Homo sapiens	111-127	
24491546-6	2014	PEITC enhances TRAIL-induced apoptosis through the downregulation of cell survival proteins and the upregulation of DR5 receptors through actions on the ROS-induced-p53.	ros	153-156	TNF receptor superfamily member 10b	Homo sapiens	116-119	
24930757-9	2014	Finally, the generation of ROS was required for CHOP and DR5 up-regulation by ilimaquinone.	ros	27-30	TNF receptor superfamily member 10b	Homo sapiens	57-60	
24930757-10	2014	These results demonstrate that ilimaquinone enhanced the sensitivity of human colon cancer cells to TRAIL-induced apoptosis through ROS-ERK/p38 MAPK-CHOP-mediated up-regulation of DR4 and DR5 expression, suggesting that ilimaquinone could be developed into an adjuvant chemotherapeutic drug.	ros	132-135	TNF receptor superfamily member 10b	Homo sapiens	188-191	
21854768-0	2011	Acrolein sensitizes human renal cancer Caki cells to TRAIL-induced apoptosis via ROS-mediated up-regulation of death receptor-5 (DR5) and down-regulation of Bcl-2.	ros	81-84	TNF receptor superfamily member 10b	Homo sapiens	129-132