PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33377976-0	2021	Sirt3 is critical for p53-mediated ferroptosis upon ROS-induced stress.	ros	52-55	tumor protein p53	Homo sapiens	22-25	
33302580-7	2020	We demonstrated that the temporal treatment of HCT116 and MCF-7 cancer cells (both p53 wild-type) with DPI caused induction of senescence, that was correlated with decreased level of ROS and upregulation of p53/p21 proteins.	ros	183-186	tumor protein p53	Homo sapiens	83-86	
33676890-7	2021	ROS significantly increase the expression of TRAIL death receptor 5 (DR5) via the p53 and C/EBP homologous protein pathways.	ros	0-3	tumor protein p53	Homo sapiens	82-85	
33347603-0	2021	Quercetin Induces p53-independent Cancer Cell Death via TFEB-mediated Lysosome Activation and ROS-dependent Ferroptosis.	ros	94-97	tumor protein p53	Homo sapiens	18-21	
33381272-7	2020	The cell model in vitro further demonstrated that p53 knockout or knockdown in the HCT116 cell and L02 cell significantly inhibited cell apoptosis and increased cell viability, presented by suppressing ROS production, oxidative stress, and the Nrf2/HO-1 pathway.	ros	202-205	tumor protein p53	Homo sapiens	50-53	
33785447-7	2021	In this review, we will summarize the roles of p53 in the regulation of glucose, lipid, amino acid, nucleotide, iron metabolism, and ROS production.	ros	133-136	tumor protein p53	Homo sapiens	47-50	
33054537-9	2021	The time dependent induction of DNA breaks demonstrated in PC3 cells treated with MPO safe concentration stimulated ROS generation and apoptotic DNA damage through increased expression of tumor suppressor p53 and Bax genes and decreased expression of Bcl2 and MDM2 genes.	ros	116-119	tumor protein p53	Homo sapiens	205-208	
33039867-0	2021	ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner.	ros	0-3	tumor protein p53	Homo sapiens	150-153	
33039867-13	2021	These results suggest that ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner.	ros	27-30	tumor protein p53	Homo sapiens	177-180	
33396077-8	2021	ROS induced alteration in p53 regulation and some mitogen/ oncogenic functions determine the transformation outcome influencing cyclin-cdk complexes.	ros	0-3	tumor protein p53	Homo sapiens	26-29	
32530119-3	2020	As results, quercetin showed contrasting dose-response to cellular behaviors dependent on the ROS-regulated p53 signaling pathways.	ros	94-97	tumor protein p53	Homo sapiens	108-111	
32738659-5	2020	Meanwhile, the intracellular ROS-P53 crosstalk can be upregulated by diallyl disulfide (up to 8-fold increase of ROS) and valproate (up to 18-fold increase of P53) to enhance early apoptosis.	ros	29-32	tumor protein p53	Homo sapiens	33-36	
32738659-5	2020	Meanwhile, the intracellular ROS-P53 crosstalk can be upregulated by diallyl disulfide (up to 8-fold increase of ROS) and valproate (up to 18-fold increase of P53) to enhance early apoptosis.	ros	29-32	tumor protein p53	Homo sapiens	159-162	
32738659-5	2020	Meanwhile, the intracellular ROS-P53 crosstalk can be upregulated by diallyl disulfide (up to 8-fold increase of ROS) and valproate (up to 18-fold increase of P53) to enhance early apoptosis.	ros	113-116	tumor protein p53	Homo sapiens	33-36	
32738659-6	2020	The synchronization of enhanced G2/M arrest and ROS-P53 crosstalk devotes to reverse the cisplatin resistance with a high level of resistance reversion index (50.22).	ros	48-51	tumor protein p53	Homo sapiens	52-55	
32687844-12	2020	In addition to upregulation of p53, its down-stream targets, AKT/mTor were also downregulated, supporting that DpdtC induced EMT inhibition was achieved through ferritinophagy-ROS vicious cycle mediated p53/AKT/mTor pathway.	ros	176-179	tumor protein p53	Homo sapiens	203-206	
32792943-6	2020	Further study of the underlying mechanism revealed that the two drugs in combination caused ROS aggregation in NSCLC cells, leading to DNA double-strand breaks and increased expression of the tumor suppressor factor p53.	ros	92-95	tumor protein p53	Homo sapiens	216-219	
32687844-0	2020	The vicious cycle between ferritinophagy and ROS production triggered EMT inhibition of gastric cancer cells was through p53/AKT/mTor pathway.	ros	45-48	tumor protein p53	Homo sapiens	121-124	
32687844-9	2020	In addition, ferritinophagy triggers Fenton reaction, resulting in ROS production which give rise of p53 response, thus the role of p53 was further investigated.	ros	67-70	tumor protein p53	Homo sapiens	101-104	
31464976-7	2020	Mechanistically, LY treatment elevated ROS generation that activates the p38 mitogen-activated protein kinases (MAPKs) and p53-dependent apoptotic program.	ros	39-42	tumor protein p53	Homo sapiens	123-126	
32256964-9	2020	In addition, autophagy inhibitors or NAC could counteract the effect of DpdtC and restore the level of p53 to the control group, indicating that the upregulation of p53 was caused by ferritinophagy-mediated ROS production.	ros	207-210	tumor protein p53	Homo sapiens	103-106	
32256964-9	2020	In addition, autophagy inhibitors or NAC could counteract the effect of DpdtC and restore the level of p53 to the control group, indicating that the upregulation of p53 was caused by ferritinophagy-mediated ROS production.	ros	207-210	tumor protein p53	Homo sapiens	165-168	
32256964-10	2020	In conclusion, our data demonstrated that the inhibition of EMT induced by DpdtC was realized through ferritinophagy-mediated ROS/p53 pathway, which supported that the activation of ferritinophagic flux was the main driving force in EMT inhibition in gastric cancer cells, and further strengthening the concept that NCOA4 participates in EMT process.	ros	126-129	tumor protein p53	Homo sapiens	130-133	
32630700-10	2020	ROS act as upstream signaling molecules to initiate apoptosis via p53/p21waf1 axis.	ros	0-3	tumor protein p53	Homo sapiens	66-69	
32092796-12	2020	These results indicated that increased miR-34c mediated synaptic and memory deficits by targeting SYT1 through ROS-JNK-p53 pathway and the miR-34c/SYT1 pathway could be considered as a promising novel therapeutic target for patients with AD.	ros	111-114	tumor protein p53	Homo sapiens	119-122	
31464976-8	2020	Inhibition of ROS generation by NAC or p38 MAPK signaling by SB203580 attenuated the p53-mediated cell cycle arrest and apoptosis induced by LY.	ros	14-17	tumor protein p53	Homo sapiens	85-88	
31283929-0	2019	ROS -mediated p53 activation by juglone enhances apoptosis and autophagy in vivo and in vitro.	ros	0-3	tumor protein p53	Homo sapiens	14-17	
31648639-7	2020	Furthermore, Ag@PTX enhanced the anti-canceractivity of A549 cells through ROS-mediated p53 and AKT signalling pathways.	ros	75-78	tumor protein p53	Homo sapiens	88-91	
31283929-10	2019	Overall, our results illustrated that JG caused apoptosis and autophagy via activating the ROS-mediated p53 pathway in human liver cancer cells in vitro and in vivo, which provided basic scientific evidence that JG serves as a potential anti-cancer agent.	ros	91-94	tumor protein p53	Homo sapiens	104-107	
31391058-10	2019	Moreover, Jinfukang induces apoptosis in CTC-TJH-01 cells through the ROS-mediated ATM/ATR-p53 pathway and DNA damage.	ros	70-73	tumor protein p53	Homo sapiens	91-94	
30895171-1	2019	Prima-1Met (APR-246) was previously shown to be dependent on glutathione inhibition and on ROS induction in cancer cells with mutated or deleted TP53.	ros	91-94	tumor protein p53	Homo sapiens	145-149	
31366086-5	2019	Depletion of p53 coincided with a moderate, LA-dependent ROS production, but was not rescued by antioxidant treatment.	ros	57-60	tumor protein p53	Homo sapiens	13-16	
30196236-0	2018	The Mutant p53-Targeting Compound APR-246 Induces ROS-Modulating Genes in Breast Cancer Cells.	ros	50-53	tumor protein p53	Homo sapiens	11-14	
30778058-4	2019	Mechanistically, miR-135 accumulates specifically in response to glutamine deprivation and requires ROS-dependent activation of mutant p53, which directly promotes miR-135 expression.	ros	100-103	tumor protein p53	Homo sapiens	135-138	
30400061-2	2019	This tumor suppression system is based upon the kill switch being triggered in cells in which p53 has been inactivated; such kill switch consisting of a rapid, catastrophic increase in ROS caused by the induction of irreversible uncompetitive inhibition of glucose-6- phosphate dehydrogenase (G6PD), which requires high concentrations of both inhibitor (DHEA) and G6P substrate.	ros	185-188	tumor protein p53	Homo sapiens	94-97	
30723502-0	2019	Autophagy Regulated by Gain of Function Mutant p53 Enhances Proteasomal Inhibitor-Mediated Cell Death through Induction of ROS and ERK in Lung Cancer Cells.	ros	123-126	tumor protein p53	Homo sapiens	47-50	
30029111-10	2018	Simultaneously, ROS induced persistent DNA-damage (Comet-assay) that stimulated G2/M arrest for p53-mediated damage-repair, aided by checkpoint-promoter (Chk1) activation and mitotic-inducers (i.e. Cdc-25, Cdk1, cyclinB1) inhibition.	ros	16-19	tumor protein p53	Homo sapiens	96-99	
30265530-10	2018	Thus, the present study revealed that N-O reduction of cyadox and ROS-mediated AKT/FOXO1 and AKT/P53 pathways were involved in growth promotion and cytotoxicity of cyadox.	ros	66-69	tumor protein p53	Homo sapiens	97-100	
29334793-6	2018	Moreover, Ru@MSNs induced ROS overproduction in cancer cells, leading to DNA damage and p53 phosphorylation, consequently promoting cancer cells apoptosis.	ros	26-29	tumor protein p53	Homo sapiens	88-91	
30265530-0	2018	N-O Reduction and ROS-Mediated AKT/FOXO1 and AKT/P53 Pathways Are Involved in Growth Promotion and Cytotoxicity of Cyadox.	ros	18-21	tumor protein p53	Homo sapiens	49-52	
29898731-13	2018	PC-3 cells lacking p53 and PTEN with reduced ROS levels showed significant activation of Akt and NF-kappaB pathway.	ros	45-48	tumor protein p53	Homo sapiens	19-22	
30029680-13	2018	CONCLUSION: Our results show that oxaliplatin mediates differential cellular responses in colon cancer cells depending on their p53 status, and demonstrate that the ROS-p53 axis is important for regulating POU3F2 and its downstream target, tNOX.	ros	165-168	tumor protein p53	Homo sapiens	169-172	
29680675-5	2018	Short-time (8-min) light irradiation produced non-lethal amount of ROS to disrupt the endosomal membranes and facilitate p53 gene release via degradation of TK-PEI, which collectively enhanced p53 expression levels toward anti-cancer gene therapy.	ros	67-70	tumor protein p53	Homo sapiens	121-124	
29680675-5	2018	Short-time (8-min) light irradiation produced non-lethal amount of ROS to disrupt the endosomal membranes and facilitate p53 gene release via degradation of TK-PEI, which collectively enhanced p53 expression levels toward anti-cancer gene therapy.	ros	67-70	tumor protein p53	Homo sapiens	193-196	
29680675-6	2018	Long-time (30-min) light irradiation at the post-transfection state generated lethal amount of ROS, which cooperatively killed cancer cells to strengthen p53 gene therapy.	ros	95-98	tumor protein p53	Homo sapiens	154-157	
30029680-0	2018	Regulation of tNOX expression through the ROS-p53-POU3F2 axis contributes to cellular responses against oxaliplatin in human colon cancer cells.	ros	42-45	tumor protein p53	Homo sapiens	46-49	
30029680-10	2018	Further experiments revealed that in p53-wild-type cells, oxaliplatin enhanced ROS generation and p53 transcriptional activation, leading to down-regulation of the transcriptional factor, POU3F2, which enhances the expression of tNOX.	ros	79-82	tumor protein p53	Homo sapiens	37-40	
30029680-11	2018	Moreover, the addition of a ROS scavenger reversed the p53 activation, POU3F2 down-regulation, and apoptosis induced by oxaliplatin in p53-wild-type cells.	ros	28-31	tumor protein p53	Homo sapiens	55-58	
30029680-11	2018	Moreover, the addition of a ROS scavenger reversed the p53 activation, POU3F2 down-regulation, and apoptosis induced by oxaliplatin in p53-wild-type cells.	ros	28-31	tumor protein p53	Homo sapiens	135-138	
30029680-12	2018	In the p53-null line, on the other hand, oxaliplatin treatment triggered less ROS generation and no p53 protein, such that POU3F2 and tNOX were not down-regulated and oxaliplatin-mediated cytotoxicity was attenuated.	ros	78-81	tumor protein p53	Homo sapiens	7-10	
29565448-3	2018	Our previous study revealed that kaempferol triggered apoptosis in human umbilical vein endothelial cells (HUVECs) by ROS-mediated p53/ATM/death receptor signaling.	ros	118-121	tumor protein p53	Homo sapiens	131-134	
29753331-1	2018	TIGAR is a p53 target gene that is known to protect cells from ROS-induced apoptosis by promoting the pentose phosphate pathway.	ros	63-66	tumor protein p53	Homo sapiens	11-14	
29179721-7	2017	Mechanistically, apigenin activated p53 that induced catalase, a ROS scavenger enzyme, and inhibited STAT3, the most important pro-survival pathway in PEL, as assessed by p53 silencing.	ros	65-68	tumor protein p53	Homo sapiens	36-39	
29431732-6	2018	Upregulation of p53 in turn disrupted the pentose phosphate pathway, leading to excessive ROS production and dormant TRC death.	ros	90-93	tumor protein p53	Homo sapiens	16-19	
29346757-5	2018	This delay requires the p53 transcriptional target CDKN1A (encoding p21) and is associated with both slower depletion of intracellular glutathione and a reduced accumulation of toxic lipid-reactive oxygen species (ROS).	ros	214-217	tumor protein p53	Homo sapiens	24-27	
28918503-8	2018	The activation of p-GSK3beta expression, cyclophilin D inhibition, and p53 activation through ROS are involved in CoQ0-induced HL-60 apoptotic cell death.	ros	94-97	tumor protein p53	Homo sapiens	71-74	
28109089-0	2017	Betulinic Acid Inhibits Cell Proliferation in Human Oral Squamous Cell Carcinoma via Modulating ROS-Regulated p53 Signaling.	ros	96-99	tumor protein p53	Homo sapiens	110-113	
28942112-4	2017	Further investigations on mechanism of action of this class of compound demonstrated that the representative compound 8k could trigger p53/Bax-independent colorectal cancer cell apoptosis via inducing ROS accumulation.	ros	201-204	tumor protein p53	Homo sapiens	135-138	
28831795-9	2017	Further, the result depicted a direct correlation between the generations of ROS with mitochondrial-dependent apoptosis through the involvement of p53 phosphorylation upon EDTFP-1 induction, suggesting this COF material is a novel chemotherapeutic agent for cancer treatment.	ros	77-80	tumor protein p53	Homo sapiens	147-150	
28912678-6	2017	These findings demonstrated that ROS might be located upstream of IL-17A and HMGB1 so that ROS can regulate HMGB1/IL-17A expression to affect the p53 and PI3K/Akt signaling pathways and therefore promote the occurrence of apoptosis in microglial cells.	ros	33-36	tumor protein p53	Homo sapiens	146-149	
28912678-6	2017	These findings demonstrated that ROS might be located upstream of IL-17A and HMGB1 so that ROS can regulate HMGB1/IL-17A expression to affect the p53 and PI3K/Akt signaling pathways and therefore promote the occurrence of apoptosis in microglial cells.	ros	91-94	tumor protein p53	Homo sapiens	146-149	
28796811-4	2017	Nonetheless, early single peak of ROS formation along with lysosomal membrane permeabilization and cathepsin activation regulated cisplatin- and UV-induced necrosis in p53-null HCT-116 cells.	ros	34-37	tumor protein p53	Homo sapiens	168-171	
28109089-13	2017	Taken together, the data demonstrated that ROS-p53 signaling was crucial for BA-exhibited antitumor effect in OSCC.	ros	43-46	tumor protein p53	Homo sapiens	47-50	
28294157-0	2017	Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation.	ros	98-101	tumor protein p53	Homo sapiens	50-53	
28571773-6	2017	In addition, DATS enhances TRAIL-induced apoptosis through the downregulation of anti-apoptotic protein (Mcl-1) and the upregulation of DR5 receptors through actions on the ROS- induced-p53.	ros	173-176	tumor protein p53	Homo sapiens	186-189	
28110188-7	2017	The complex 1 and 2 treated cells show increased level of intracellular ROS generation which was preceded by p53 activation.	ros	72-75	tumor protein p53	Homo sapiens	109-112	
27913286-6	2017	Coumestrol treatment induced ROS generation coupled to DNA fragmentation, up-regulation of p53/p21, cell cycle arrest at G1/S phase, mitochondrial membrane depolarization and caspases 9/3 activation.	ros	29-32	tumor protein p53	Homo sapiens	91-94	
27729002-12	2017	In conclusion, we identified that miR-30 functioned as a potential oncomiR through P53/ROS-mediated regulation of mitochondrial apoptotic pathway.	ros	87-90	tumor protein p53	Homo sapiens	83-86	
27913286-10	2017	In conclusion, copper targeted ROS-mediated p53-dependent mechanism better explains the cytotoxic action of coumestrol in MCF-7 cells.	ros	31-34	tumor protein p53	Homo sapiens	44-47	
32263487-4	2016	The internalized BSeC@MSNs-RGD triggered mitochondrial dysfunction and intracellular ROS overproduction, which subsequently activated the p53 and MAPKs pathways.	ros	85-88	tumor protein p53	Homo sapiens	138-141	
27568863-6	2016	We observed an increase in p53 levels, which was dependent on ROS production.	ros	62-65	tumor protein p53	Homo sapiens	27-30	
27542250-2	2016	Recently, we have reported that increased mitochondrial fission promotes autophagy and apoptosis resistance in hepatocellular carcinoma (HCC) cell through ROS-mediated coordinated regulation of NF-kappaB and p53 pathways.	ros	155-158	tumor protein p53	Homo sapiens	208-211	
27124102-0	2016	Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways.	ros	106-109	tumor protein p53	Homo sapiens	159-163	
27711766-6	2016	An intimate relationship between p53, ROS production and extent of cell death has also been established using p53 wild, null and mutant type cancer cells.	ros	38-41	tumor protein p53	Homo sapiens	110-113	
27422544-6	2016	ROS promotes p53 inducing MALM (Mieap-induced accumulation of lysosome-like organelles within mitochondria) to repair dysfunctional mitochondria and MIV (Mieap-induced vacuole) to accomplish damaged mitochondria degradation.	ros	0-3	tumor protein p53	Homo sapiens	13-16	
32263394-4	2016	Furthermore, the nanosystem (Bio-PLGA@Ru) was efficiently internalized by cancer cells by the lipid raft-mediated endocytosis pathway, triggered ROS overproduction and activated p53-mediated apoptosis in cancer cells.	ros	145-148	tumor protein p53	Homo sapiens	178-181	
27414741-0	2016	ROS-mediated apoptosis of HAPI microglia through p53 signaling following PFOS exposure.	ros	0-3	tumor protein p53	Homo sapiens	49-52	
27414741-6	2016	Interestingly, NAC, a ROS inhibitor, inhibited p53 expression, and decreased the apoptosis of HAPI microglia.	ros	22-25	tumor protein p53	Homo sapiens	47-50	
27414741-7	2016	Taken together, these findings suggest that upregulated production of ROS plays a vital role in PFOS-mediated apoptosis in HAPI microglia via the modulation of p53 signaling.	ros	70-73	tumor protein p53	Homo sapiens	160-163	
27124102-7	2016	We further demonstrated that the survival-promoting role of increased mitochondrial fission was mediated via elevated ROS production and subsequent activation of AKT, which facilitated MDM2-mediated TP53 degradation, and NFKBIA- and IKK-mediated transcriptional activity of NFKB in HCC cells.	ros	118-121	tumor protein p53	Homo sapiens	199-203	
27010918-0	2016	Heat Killed Attenuated Leishmania Induces Apoptosis of HepG2 Cells Through ROS Mediated p53 Dependent Mitochondrial Pathway.	ros	75-78	tumor protein p53	Homo sapiens	88-91	
26152521-9	2016	Pretreatment of cells with ROS scavenger N-acetyl cysteine abrogated the inhibitory effect of CA on the JAK2-STAT3/Src-STAT3 signaling and rescued cells from CA-induced apoptosis by blocking the induction of p53 and the cleavage of caspase-3 and PARP in HCT116 cells.	ros	27-30	tumor protein p53	Homo sapiens	208-211	
26942697-0	2016	Repeated PM2.5 exposure inhibits BEAS-2B cell P53 expression through ROS-Akt-DNMT3B pathway-mediated promoter hypermethylation.	ros	69-72	tumor protein p53	Homo sapiens	46-49	
26942697-8	2016	In conclusion, our results strongly suggest that repeated exposure to PM2.5 induces epigenetic silencing of P53 through ROS-Akt-DNMT3B pathway-mediated promoter hypermethylation, which not only provides a possible explanation for PM-induced lung cancer, but also may help to identify specific interventions to prevent PM-induced lung carcinogenesis.	ros	120-123	tumor protein p53	Homo sapiens	108-111	
26775629-5	2016	Using BCC/KMC1 cell line as a model, the upstream signaling of p53 activation was dissected by over-expression of TLR7/8, the addition of ROS scavenger, ATM/ATR inhibitors and pan-caspase inhibitor.	ros	138-141	tumor protein p53	Homo sapiens	63-66	
26775629-8	2016	In BCC/KMC1 cells, the induction of p53 by IMQ was achieved through increased ROS production to stimulate the ATM/ATR-Chk1/Chk2 axis but was not mediated by inducing DNA damage.	ros	78-81	tumor protein p53	Homo sapiens	36-39	
27010918-11	2016	In conclusion, Leishmania donovani UR6 efficiently induces apoptosis in HepG2 cells through ROS mediated p53 dependent mitochondrial pathway.	ros	92-95	tumor protein p53	Homo sapiens	105-108	
27010918-13	2016	From our study we found that Leishmania donovani UR6 efficiently induced apoptosis in HepG2 cells through ROS mediated p53 dependent mitochondrial pathway.	ros	106-109	tumor protein p53	Homo sapiens	119-122	
26205253-5	2015	Internalized nanoparticles trigger glioma cell apoptosis by activation of ROS-mediated p53 phosphorylation.	ros	74-77	tumor protein p53	Homo sapiens	87-90	
26884717-12	2016	Taken together, these suggested that CsA could suppress ROS-mediated p53 mitochondrial distribution and cell apoptosis depended on its inhibition effect to mitochondrial permeability transition.	ros	56-59	tumor protein p53	Homo sapiens	69-72	
26368019-12	2015	Inhibition of ROS and p53 respectively reversed the cell death induced by 5-Fu + Gyp, suggesting the key roles of ROS and p53 in the process.	ros	14-17	tumor protein p53	Homo sapiens	122-125	
26368019-12	2015	Inhibition of ROS and p53 respectively reversed the cell death induced by 5-Fu + Gyp, suggesting the key roles of ROS and p53 in the process.	ros	114-117	tumor protein p53	Homo sapiens	22-25	
26507802-4	2016	H-RuBmp demonstrated a higher interaction potency with the cell membrane and induced higher levels of ROS overproduction in cancer cells to regulate the AKT, MAPK, and p53 signaling pathways.	ros	102-105	tumor protein p53	Homo sapiens	168-171	
27703600-5	2016	Our results indicate that CH not only is a structural component of cell membrane but also functionally contributes to regulating cellular senescence by modulating cell cycle, autophagy, and the ROS/p53/p21Cip1/Waf1 signaling pathway.	ros	194-197	tumor protein p53	Homo sapiens	198-201	
26465677-0	2015	A Novel Platinum-Maurocalcine Conjugate Induces Apoptosis of Human Glioblastoma Cells by Acting through the ROS-ERK/AKT-p53 Pathway.	ros	108-111	tumor protein p53	Homo sapiens	120-123	
25359126-0	2015	The Apoptotic Effect of Plant Based Nanosilver in Colon Cancer Cells is a p53 Dependent Process Involving ROS and JNK Cascade.	ros	106-109	tumor protein p53	Homo sapiens	74-77	
26073944-5	2015	We linked ROS production and induction of the mitochondrial permeability transition pore (MPTP) via cyclophilin D and p53 as mechanisms of EPHOSS.	ros	10-13	tumor protein p53	Homo sapiens	118-121	
26202022-4	2015	As a sensor of cellular stress, p53 is a relevant messenger of cell death signaling in ROS-driven photodynamic therapy (PDT) of cancer.	ros	87-90	tumor protein p53	Homo sapiens	32-35	
26107995-7	2015	Interestingly, RuPOP@MWCNTs significantly enhanced the anticancer efficacy of clinically used X-ray against R-HepG2 cells through induction of apoptosis and G0/G1 cell cycle arrest, with the involvement of ROS overproduction, which activated several downstream signaling pathways, including DNA damage-mediated p53 phosphorylation, activation of p38, and inactivation of AKT and ERK.	ros	206-209	tumor protein p53	Homo sapiens	311-314	
25359126-5	2015	PD-AgNP-mediated apoptosis in CRCs is a p53 dependent process involving ROS and JNK cascade.	ros	72-75	tumor protein p53	Homo sapiens	40-43	
25135223-8	2014	Excessive ROS triggered DNA damage and activated downstream signaling pathways, including the phosphorylation of p53 and p38MAPK, and down-regulation of phosphorylated AKT and ERK, finally resulted in increase of radiosensitivity and inhibition of tumor reproduction.	ros	10-13	tumor protein p53	Homo sapiens	113-116	
25537301-9	2015	Moreover, studies also found that ROS acted as an upstream mediator in NB/BDCur-induced HepG2 cell growth inhibition and led to DNA damage with up-regulation of the expression level of phosphorylated ATM and p53.	ros	34-37	tumor protein p53	Homo sapiens	208-211	
25511708-0	2015	Sigma 1 Receptor antagonist potentiates the anti-cancer effect of p53 by regulating ER stress, ROS production, Bax levels, and caspase-3 activation.	ros	95-98	tumor protein p53	Homo sapiens	66-69	
26180584-6	2015	This decrease seemed to be the main signal responsible for maintaining the intracellular redox homeostasis hindering the activation of p53 induced by ROS, p38MAPK, and PKCdelta.	ros	150-153	tumor protein p53	Homo sapiens	135-138	
24986024-7	2015	The less effectiveness could be due to the induction of ROS and p53 by UVB because removing ROS by L-NAC (10 mm) in p53 null cells could lead to alternative splicing of hdm2 upon UVB irradiation.	ros	56-59	tumor protein p53	Homo sapiens	116-119	
24986024-7	2015	The less effectiveness could be due to the induction of ROS and p53 by UVB because removing ROS by L-NAC (10 mm) in p53 null cells could lead to alternative splicing of hdm2 upon UVB irradiation.	ros	92-95	tumor protein p53	Homo sapiens	64-67	
24986024-7	2015	The less effectiveness could be due to the induction of ROS and p53 by UVB because removing ROS by L-NAC (10 mm) in p53 null cells could lead to alternative splicing of hdm2 upon UVB irradiation.	ros	92-95	tumor protein p53	Homo sapiens	116-119	
25087850-9	2014	Excess ROS amplified apoptotic signals by activating many downstream pathways such as p53 and MAPK pathways to promote cell apoptosis.	ros	7-10	tumor protein p53	Homo sapiens	86-89	
25350363-6	2014	The cytotoxic effect of 1 in U87 cells could be related to its ability to provoke the release of ROS, suggesting that the cytotoxicity of 1 might be somehow p53 dependent.	ros	97-100	tumor protein p53	Homo sapiens	157-160	
25305377-7	2014	ROS further led to symptoms of early apoptosis by deregulating Akt (Protein Kinase B) and activating c-Jun N-terminal Kinase (JNK), p38 Mitogen Activated Protein Kinase (MAPK), p53, and autophagy starting from ~8h of incubation.	ros	0-3	tumor protein p53	Homo sapiens	177-180	
24412988-5	2014	An increasing number of cytosolic and mitochondrial proteins involved in mitochondrial metabolism and respiration are regulated by p53, which influences mitochondrial ROS production as well.	ros	167-170	tumor protein p53	Homo sapiens	131-134	
32261761-7	2014	Internalized FAC@CurP-SeNPs triggers intracellular ROS overproduction, thus activates p53, MAPKs pathways and inhibits NFkappaB and to promote cell apoptosis.	ros	51-54	tumor protein p53	Homo sapiens	86-89	
24867259-0	2014	Nutlin-3 induces BCL2A1 expression by activating ELK1 through the mitochondrial p53-ROS-ERK1/2 pathway.	ros	84-87	tumor protein p53	Homo sapiens	80-83	
24867259-3	2014	However, we previously demonstrated that the nutlin-3-induced mitochondrial translocation of p53 stimulates ERK1/2 activation, an anti-apoptosis signal, via mitochondrial ROS generation.	ros	171-174	tumor protein p53	Homo sapiens	93-96	
24491546-6	2014	PEITC enhances TRAIL-induced apoptosis through the downregulation of cell survival proteins and the upregulation of DR5 receptors through actions on the ROS-induced-p53.	ros	153-156	tumor protein p53	Homo sapiens	165-168	
24555485-0	2014	Synergistic induction of apoptosis by methylseleninic acid and cisplatin, the role of ROS-ERK/AKT-p53 pathway.	ros	86-89	tumor protein p53	Homo sapiens	98-101	
24366007-8	2014	Notably, the levels of nutlin-3-induced ROS were correlated with the mitochondrial translocation of p53 and this induction was prevented by PFT-mu, an inhibitor of the mitochondrial translocation of p53.	ros	40-43	tumor protein p53	Homo sapiens	100-103	
26432589-10	2014	These results clearly demonstrate that the bystander effect is p53-dependent for low LET irradiation, but it is p53-independent for high LET irradiation which may be because of p53-independent ROS generation due to mitochondrial dysfunction.	ros	193-196	tumor protein p53	Homo sapiens	112-115	
26432589-10	2014	These results clearly demonstrate that the bystander effect is p53-dependent for low LET irradiation, but it is p53-independent for high LET irradiation which may be because of p53-independent ROS generation due to mitochondrial dysfunction.	ros	193-196	tumor protein p53	Homo sapiens	112-115	
24787294-2	2014	Genetic changes in the carcinoma cells, such as alterations to TP53, NOTCH1, and specific gene expression profiles, contribute to derangements in cancer and microenvironment cells such as increased ROS, overproduction of cytokines, and epithelial to mesenchymal transition (EMT).	ros	198-201	tumor protein p53	Homo sapiens	63-67	
24366007-8	2014	Notably, the levels of nutlin-3-induced ROS were correlated with the mitochondrial translocation of p53 and this induction was prevented by PFT-mu, an inhibitor of the mitochondrial translocation of p53.	ros	40-43	tumor protein p53	Homo sapiens	199-202	
24366007-11	2014	Collectively, these results suggest that nutlin-3 induces HO-1 expression via the activation of both JNK which is dependent on ROS generated by p53 translocated to the mitochondria and p38 MAPK which appears to be stimulated by a ROS-independent mechanism, and this HO-1 induction may inhibit nutlin-3-induced apoptosis, constituting a negative feedback loop of p53-induced apoptosis.	ros	127-130	tumor protein p53	Homo sapiens	144-147	
24269727-0	2014	ROS and RNS induced apoptosis through p53 and iNOS mediated pathway by a dibasic hydroxamic acid molecule in leukemia cells.	ros	0-3	tumor protein p53	Homo sapiens	38-41	
24269727-9	2014	Therefore OBPHA, having a structurally relevant pharmacophore provides important insight into the development of new ROS and RNS generating chemicals inducing p53 dependent apoptosis.	ros	117-120	tumor protein p53	Homo sapiens	159-162	
23499005-4	2013	Moreover, B55alpha is specifically induced upon glutamine deprivation in a ROS-dependent manner to activate p53 and promote cell survival.	ros	75-78	tumor protein p53	Homo sapiens	108-111	
23529952-5	2013	Results indicate that PEG2000-DPSE-QUE-NPS showed dose-dependent cytotoxicity to C6 glioma cells and enhanced ROS accumulation induced upregulation of p53 protein, which was accompanied with an increase in cytochrome c and caspase-3 protein levels.	ros	110-113	tumor protein p53	Homo sapiens	151-154	
23574722-7	2013	siRNA-mediated depletion of GLS2 sensitizes cells to ROS-induced apoptosis, suggesting that the TAp63/GLS2 axis can be functionally important as a cellular antioxidant pathway in the absence of p53.	ros	53-56	tumor protein p53	Homo sapiens	194-197	
21308489-8	2012	The present study indicates that p53 null osteosarcoma MG63 cells are susceptible to the ATO; the inhibition of catalase and the resulted intracellular ROS accumulation are an important molecular mechanism under which ATO induces apoptosis of p53-deficient osteosarcoma cells.	ros	152-155	tumor protein p53	Homo sapiens	33-36	
23395165-2	2013	A new study shows that, upon serine starvation, the tumor suppressor p53 activates p21 to shift metabolic flux from purine biosynthesis to glutathione production, which enhances cellular proliferation and viability by combating ROS (Maddocks et al., 2013).	ros	228-231	tumor protein p53	Homo sapiens	69-72	
23252827-4	2013	Furthermore, inhibition of the miR-183/96/182 cluster induced ROS-mediated AKT/survival independent of three target genes FGF9, CPEB1, and FOXO1, and inhibition of the miRNA cluster induced p53/apoptosis signaling, which was dependent on these same genes.	ros	62-65	tumor protein p53	Homo sapiens	190-193	
23950593-10	2013	CONCLUSIONS: These results suggested that BDMC-induced ROS accumulation may contribute to its inhibitory effect on MCF-7 cell viability through regulation of p53/p21 and p16/Rb pathways.	ros	55-58	tumor protein p53	Homo sapiens	158-161	
23287470-0	2013	A novel link between p53 and ROS.	ros	29-32	tumor protein p53	Homo sapiens	21-24	
21308489-8	2012	The present study indicates that p53 null osteosarcoma MG63 cells are susceptible to the ATO; the inhibition of catalase and the resulted intracellular ROS accumulation are an important molecular mechanism under which ATO induces apoptosis of p53-deficient osteosarcoma cells.	ros	152-155	tumor protein p53	Homo sapiens	243-246	
21861192-7	2011	ROS inhibition prevented p73 and Noxa expression but not p53 and p21 expression, suggesting a role for Noxa in p53-independent apoptosis in melanoma cells.	ros	0-3	tumor protein p53	Homo sapiens	111-114	
22052190-9	2012	These results suggest that PATZ1 may have an important role in the regulation of EC senescence through an ROS-mediated p53-dependent pathway and contribute to vascular diseases associated with aging.	ros	106-109	tumor protein p53	Homo sapiens	119-122	
22007260-4	2012	Rhein induced dose- and time-dependent manners increase in caspase-9-mediated apoptosis correlating with activation of ROS-mediated activation of NF-kappaB- and p53-signaling pathways in both cell types.	ros	119-122	tumor protein p53	Homo sapiens	161-164	
22242180-9	2012	Thus this study suggests that ROS/RNS contributed to change of p53 tertiary structure and that unfolded p53 can be considered as an early marker of oxidative imbalance in these patients.	ros	30-33	tumor protein p53	Homo sapiens	63-66	
20940027-5	2011	Furthermore, western blot analysis of p53, JNK, and caspase-3 showed that ROS generation was accompanied by JNK activation.	ros	74-77	tumor protein p53	Homo sapiens	38-41	
22055193-7	2011	Lpin1 expression in response to nutritional stress is controlled through the ROS-ATM-p53 pathway and is conserved in human cells.	ros	77-80	tumor protein p53	Homo sapiens	85-88	
22041887-8	2011	In coculture, tamoxifen induces the upregulation of TIGAR (TP53-induced glycolysis and apoptosis regulator), a p53 regulated gene that simultaneously inhibits glycolysis, autophagy and apoptosis and reduces ROS generation, thereby promoting oxidative mitochondrial metabolism.	ros	207-210	tumor protein p53	Homo sapiens	111-114	
21425328-11	2011	In conclusion, ROS dependent-ATM/p53 signaling pathway is involved in HMJ-30-induced apoptosis in U-2 OS cells.	ros	15-18	tumor protein p53	Homo sapiens	33-36	
21099361-7	2010	In addition, p53-induced increases in intracellular levels of ROS were also inhibited in cells overexpressing Nek6.	ros	62-65	tumor protein p53	Homo sapiens	13-16	
21042727-6	2010	In the presence of p53, increased ROS from OXPHOS increases the expression of p53 target genes known to modulate metabolism, including synthesis of cytochrome c oxidase 2 (SCO2) and TP53-induced glycolysis and apoptosis regulator (TIGAR).	ros	34-37	tumor protein p53	Homo sapiens	19-22	
21042727-6	2010	In the presence of p53, increased ROS from OXPHOS increases the expression of p53 target genes known to modulate metabolism, including synthesis of cytochrome c oxidase 2 (SCO2) and TP53-induced glycolysis and apoptosis regulator (TIGAR).	ros	34-37	tumor protein p53	Homo sapiens	78-81	
17567683-4	2007	Downregulation of p53 resulted in the inhibition of p53-regulated antioxidant enzymes and elevated intracellular ROS in SiHa cells.	ros	113-116	tumor protein p53	Homo sapiens	18-21	
20600834-9	2010	Human prostate and prostate cancer tissues showed an abundant presence of glut-p53 in luminal epithelium, a site well known to generate ROS.	ros	136-139	tumor protein p53	Homo sapiens	79-82	
20729567-3	2010	The control of ROS and senescence by p53 may help to explain how p53 can function to both restrain and promote aging.	ros	15-18	tumor protein p53	Homo sapiens	37-40	
20729567-3	2010	The control of ROS and senescence by p53 may help to explain how p53 can function to both restrain and promote aging.	ros	15-18	tumor protein p53	Homo sapiens	65-68	
19010591-5	2009	Moreover, we confirmed that the ROS-p38-p53 pathway was involved in PCL-induced autophagy.	ros	32-35	tumor protein p53	Homo sapiens	40-43	
17567683-6	2007	Under mild or severe H2O2-induced stress, p53-deficient SiHa cells exhibited much higher ROS levels than control SiHa cells.	ros	89-92	tumor protein p53	Homo sapiens	42-45	
15908180-6	2005	Furthermore, the synergistic effect of TNF-alpha/IFN-gamma on apoptosis and ROS production was further potentiated by the overexpression of wild-type p53, but not with mutant p53.	ros	76-79	tumor protein p53	Homo sapiens	150-153	
17184774-0	2007	Diphenyleneiodonium induces ROS-independent p53 expression and apoptosis in human RPE cells.	ros	28-31	tumor protein p53	Homo sapiens	44-47	
17184774-5	2007	ROS have been implicated as a key factor in the activation of p53 by many chemotherapeutic drugs.	ros	0-3	tumor protein p53	Homo sapiens	62-65	
17184774-10	2007	We conclude that DPI induces the expression of p53 by ROS-independent mechanism in ARPE-19 cells, and renders cells sensitive to drug-induced apoptosis by induction of p53 expression.	ros	54-57	tumor protein p53	Homo sapiens	47-50	
34653407-6	2021	We found that AZD2461 reduced cell proliferation in wtp53 and p53-/- cancer cells by increasing ROS and DNA damage, while R273H mutant (mut) p53 counteracted these effects.	ros	96-99	tumor protein p53	Homo sapiens	62-65	
15880691-8	2005	Disruption of p53 expression attenuated the depolarization of the mitochondrial membrane and ROS generation.	ros	93-96	tumor protein p53	Homo sapiens	14-17	
14660625-9	2004	rho(0) cells were resistant to p53, and intracellular ROS contents after p53 expression were lower compared with parental cells.	ros	54-57	tumor protein p53	Homo sapiens	73-76	
34878954-0	2021	Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway.	ros	93-96	tumor protein p53	Homo sapiens	104-108	
34878954-0	2021	Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway.	ros	93-96	tumor protein p53	Homo sapiens	109-112	
34878954-2	2021	This study demonstrates that autophagy inhibition induced by MCOLN1/TRPML1 suppresses cancer metastasis by evoking the ROS-mediated TP53/p53 pathway.	ros	119-122	tumor protein p53	Homo sapiens	132-136	
34878954-2	2021	This study demonstrates that autophagy inhibition induced by MCOLN1/TRPML1 suppresses cancer metastasis by evoking the ROS-mediated TP53/p53 pathway.	ros	119-122	tumor protein p53	Homo sapiens	137-140	
34878954-5	2021	Third, we demonstrate that the elevated ROS resulting from autophagy inhibition subsequently triggers TP53 activity, which in turn modulates expression of its downstream targets which are involved in a broad spectrum of the metastatic cascade to suppress metastasis including MMP members and TWIST.	ros	40-43	tumor protein p53	Homo sapiens	102-106	
34878954-6	2021	In summary, our findings have established a mechanism by which autophagy inhibition suppresses metastasis via the ROS-TP53 signaling pathway.	ros	114-117	tumor protein p53	Homo sapiens	118-122	
35215995-9	2022	The ROS scavenger N-acetyl-l-cysteine (NAC) and the p53 specific inhibitor Pifithrin-alpha (PFT-alpha) suppressed PEDV-induced apoptosis and impeded viral replication, suggesting that ROS and p53 play an important role in PEDV-induced apoptosis and viral replication.	ros	4-7	tumor protein p53	Homo sapiens	192-195	
34343634-9	2021	Moreover, RRP15 depletion in p53-mutant PLC5 and p53-deleted Hep3B cells induced metabolic shift from the glycolytic pentose-phosphate to mitochondrial oxidative phosphorylation via regulating a series of key genes such as HK2 and TIGAR, and thus, promoted the generation of ROS and apoptosis.	ros	275-278	tumor protein p53	Homo sapiens	29-32	
34343634-9	2021	Moreover, RRP15 depletion in p53-mutant PLC5 and p53-deleted Hep3B cells induced metabolic shift from the glycolytic pentose-phosphate to mitochondrial oxidative phosphorylation via regulating a series of key genes such as HK2 and TIGAR, and thus, promoted the generation of ROS and apoptosis.	ros	275-278	tumor protein p53	Homo sapiens	49-52	
34314818-4	2021	EAA pretreatment increased the HaCaT cell viability but suppressed ROS-mediated p53/POMC/alpha-MSH pathways in UVA-irradiated cells.	ros	67-70	tumor protein p53	Homo sapiens	80-83	
34331475-0	2021	Curcumin induced G2/M cycle arrest in SK-N-SH neuroblastoma cells through the ROS-mediated p53 signaling pathway.	ros	78-81	tumor protein p53	Homo sapiens	91-94	
34331475-6	2021	Furthermore, curcumin promoted the overproduction of intracellular ROS and apoptosis induced by activating p53 and Bcl-2 signal pathways.	ros	67-70	tumor protein p53	Homo sapiens	107-110	
35065161-6	2022	Increased ROS production by IMPAs also promotes p53 mediated cell cycle arrest through the inactivation of p38MAPK.	ros	10-13	tumor protein p53	Homo sapiens	48-51	
35074406-0	2022	HIWI2 induces G2/M cell cycle arrest and apoptosis in human fibrosarcoma via the ROS/DNA damage/p53 axis.	ros	81-84	tumor protein p53	Homo sapiens	96-99	
35074406-11	2022	SIGNIFICANCE: These results are the first to show that HIWI2 acts as a tumor suppressor in fibrosarcoma by modulating the ROS/DNA damage/p53 pathway.	ros	122-125	tumor protein p53	Homo sapiens	137-140	
34301789-7	2021	Our studies reveal an unexpected role for mitochondria downstream of NPM1c and implicate a mitochondrial/ROS/PML/TP53 senescence pathway as an effector of ActD-based therapies.	ros	105-108	tumor protein p53	Homo sapiens	113-117	
34485982-0	2021	Activation of P53 Via Nutlin-3a Reveals Role for P53 In ROS Signaling During Cardiac Differentiation of hiPSCs.	ros	56-59	tumor protein p53	Homo sapiens	49-52	
35087226-3	2022	Unlike apoptotic cell death, activation of p53 alone is not sufficient to induce ferroptosis directly; instead, through its metabolic targets, p53 is able to modulate the ferroptosis response in the presence of ferroptosis inducers such as GPX4 inhibitors or high levels of ROS.	ros	274-277	tumor protein p53	Homo sapiens	143-146	
35215995-9	2022	The ROS scavenger N-acetyl-l-cysteine (NAC) and the p53 specific inhibitor Pifithrin-alpha (PFT-alpha) suppressed PEDV-induced apoptosis and impeded viral replication, suggesting that ROS and p53 play an important role in PEDV-induced apoptosis and viral replication.	ros	184-187	tumor protein p53	Homo sapiens	52-55	
35042627-15	2022	CONCLUSION: H2O2 increases ROS levels, which activates the ERK1/2 and p38 MAPK pathways to induce the premature senescence of melanocytes through p21 via a p53-independent pathway and consequently disrupts melanosome transfer.	ros	27-30	tumor protein p53	Homo sapiens	156-159	
35069864-8	2022	Preliminary results indicated that PCA suppressed ROS-induced senescence in NP cells via both the p16 and p53 pathways.	ros	50-53	tumor protein p53	Homo sapiens	106-109