PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10416947-0	1999	High-dose biotin, an inducer of glucokinase expression, may synergize with chromium picolinate to enable a definitive nutritional therapy for type II diabetes.	Biotin	10-16	glucokinase	Homo sapiens	32-43	
10416947-4	1999	In supraphysiological concentrations, biotin promotes the transcription and translation of the GK gene in hepatocytes; this effect appears to be mediated by activation of soluble guanylate cyclase.	Biotin	38-44	glucokinase	Homo sapiens	95-97	
10416947-5	1999	More recent evidence indicates that biotin likewise increases GK activity in islet cells.	Biotin	36-42	glucokinase	Homo sapiens	62-64	
6095148-0	1984	Biotin increases cGMP and glucokinase in liver cells.	Biotin	0-6	glucokinase	Homo sapiens	26-37	
30284103-9	2019	In silico target prediction revealed that GTPase HRas (HRas), tyrosine-protein phosphatase nonreceptor type 1 (PTP1B), and glucokinase are the probable targets for biotin.	Biotin	164-170	glucokinase	Homo sapiens	123-134	
27692165-5	2016	Studies in rodents and in cultured hepatocytes demonstrate that, in the context of low insulin exposure, supra-physiological levels of biotin induce increased expression of GK while suppressing that of the key gluconeogenic enzyme phosphoenolpyruvate carboxykinase.	Biotin	135-141	glucokinase	Homo sapiens	173-175	
25929424-7	2015	Glucokinase and PEPCK are also regulated in opposite directions by the vitamin biotin, acting at the transcriptional level.	Biotin	71-85	glucokinase	Homo sapiens	0-11