PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10416947-0 1999 High-dose biotin, an inducer of glucokinase expression, may synergize with chromium picolinate to enable a definitive nutritional therapy for type II diabetes. Biotin 10-16 glucokinase Homo sapiens 32-43 10416947-4 1999 In supraphysiological concentrations, biotin promotes the transcription and translation of the GK gene in hepatocytes; this effect appears to be mediated by activation of soluble guanylate cyclase. Biotin 38-44 glucokinase Homo sapiens 95-97 10416947-5 1999 More recent evidence indicates that biotin likewise increases GK activity in islet cells. Biotin 36-42 glucokinase Homo sapiens 62-64 6095148-0 1984 Biotin increases cGMP and glucokinase in liver cells. Biotin 0-6 glucokinase Homo sapiens 26-37 30284103-9 2019 In silico target prediction revealed that GTPase HRas (HRas), tyrosine-protein phosphatase nonreceptor type 1 (PTP1B), and glucokinase are the probable targets for biotin. Biotin 164-170 glucokinase Homo sapiens 123-134 27692165-5 2016 Studies in rodents and in cultured hepatocytes demonstrate that, in the context of low insulin exposure, supra-physiological levels of biotin induce increased expression of GK while suppressing that of the key gluconeogenic enzyme phosphoenolpyruvate carboxykinase. Biotin 135-141 glucokinase Homo sapiens 173-175 25929424-7 2015 Glucokinase and PEPCK are also regulated in opposite directions by the vitamin biotin, acting at the transcriptional level. Biotin 71-85 glucokinase Homo sapiens 0-11