PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2783860-0 1989 Inhibition of platelet adhesion to fibronectin, fibrinogen, and von Willebrand factor substrates by complex gangliosides. Gangliosides 108-120 fibronectin 1 Homo sapiens 35-46 2783860-2 1989 Complex gangliosides were observed to inhibit the adhesion of thrombin-activated platelets to substrates of fibronectin, von Willebrand factor, and fibrinogen. Gangliosides 8-20 fibronectin 1 Homo sapiens 108-119 2458363-1 1988 The identification of specific cell surface glycoprotein receptors for Arg-Gly-Asp-containing extracellular matrix proteins such as fibronectin has focused attention on the role of gangliosides in this process. Gangliosides 181-193 fibronectin 1 Homo sapiens 132-143 2968913-0 1988 Involvement of gangliosides and glycoprotein fibronectin receptors in cellular adhesion to fibronectin. Gangliosides 15-27 fibronectin 1 Homo sapiens 91-102 2966069-0 1988 Ganglioside-dependent adhesion events of human neuroblastoma cells regulated by the RGDS-dependent fibronectin receptor and proteoglycans. Gangliosides 0-11 fibronectin 1 Homo sapiens 99-110 6430916-0 1984 Incorporation of fluorescent gangliosides into human fibroblasts: mobility, fate, and interaction with fibronectin. Gangliosides 29-41 fibronectin 1 Homo sapiens 103-114 3030576-3 1986 Using this approach, specific gangliosides have been identified as the receptors for certain bacterial toxins and viruses and as important factors in the organization of fibronectin into an extracellular matrix. Gangliosides 30-42 fibronectin 1 Homo sapiens 170-181 3957921-0 1986 Localization of the ganglioside-binding site of fibronectin. Gangliosides 20-31 fibronectin 1 Homo sapiens 48-59 3957921-1 1986 It has been demonstrated via biological assays that fibronectin possesses a receptor for gangliosides that is involved in cell adhesion and restoration of the normal morphology of transformed cells. Gangliosides 89-101 fibronectin 1 Homo sapiens 52-63 3957921-5 1986 Using the fluorescence polarization assay developed in this study for measurement of ganglioside binding to fibronectin, it is demonstrated that gangliosides bind to the 31,000-dalton amino terminal heparin-binding domain of fibronectin. Gangliosides 85-96 fibronectin 1 Homo sapiens 108-119 3957921-5 1986 Using the fluorescence polarization assay developed in this study for measurement of ganglioside binding to fibronectin, it is demonstrated that gangliosides bind to the 31,000-dalton amino terminal heparin-binding domain of fibronectin. Gangliosides 85-96 fibronectin 1 Homo sapiens 225-236 3957921-5 1986 Using the fluorescence polarization assay developed in this study for measurement of ganglioside binding to fibronectin, it is demonstrated that gangliosides bind to the 31,000-dalton amino terminal heparin-binding domain of fibronectin. Gangliosides 145-157 fibronectin 1 Homo sapiens 108-119 3957921-5 1986 Using the fluorescence polarization assay developed in this study for measurement of ganglioside binding to fibronectin, it is demonstrated that gangliosides bind to the 31,000-dalton amino terminal heparin-binding domain of fibronectin. Gangliosides 145-157 fibronectin 1 Homo sapiens 225-236 3957921-6 1986 A ganglioside-Sepharose affinity column has been constructed which specifically binds the 31,000-dalton amino terminal fragment of fibronectin. Gangliosides 2-13 fibronectin 1 Homo sapiens 131-142 3005335-3 1986 Cells that are preattached to a fibronectin substrate can also be induced to detach and round up in the presence of purified anti-ganglioside Mab. Gangliosides 130-141 fibronectin 1 Homo sapiens 32-43 6430916-8 1984 Using antifibronectin antibodies and indirect immunofluorescence, these gangliosides were found to co-distribute with fibrillar fibronectin. Gangliosides 72-84 fibronectin 1 Homo sapiens 10-21 6430916-9 1984 Thus, exogenous gangliosides appear to be stably inserted into the lipid bilayer of the plasma membrane and to diffuse freely in its plane as well as form a less mobile state with the fibrillar networks of fibronectin associated with the cells. Gangliosides 16-28 fibronectin 1 Homo sapiens 206-217 2351703-1 1990 Some neuron-derived cells, such as neuroblastoma cells, adhere and extend neurites on fibronectin (FN) substrata by processes that can be independent of binding to the Arg-Gly-Asp-Ser sequence (RGDS in FN) and independent of proteoglycan/ganglioside-binding activities of FN. Gangliosides 238-249 fibronectin 1 Homo sapiens 99-101 11276053-6 2001 Based on different in vitro approaches, we found that the substrate-bound glycoprotein selectively inhibits the fibronectin-dependent: (1) neurite outgrowth from dorsal root ganglion neurons (strongly expressing alpha5beta1 integrin and the disialoganglioside GD3) by a ganglioside-sensitive signaling mechanism; and (2) migration of primary myoblasts and other non-neuronal cells in a ganglioside-independent manner. Gangliosides 248-259 fibronectin 1 Homo sapiens 112-123 11276053-6 2001 Based on different in vitro approaches, we found that the substrate-bound glycoprotein selectively inhibits the fibronectin-dependent: (1) neurite outgrowth from dorsal root ganglion neurons (strongly expressing alpha5beta1 integrin and the disialoganglioside GD3) by a ganglioside-sensitive signaling mechanism; and (2) migration of primary myoblasts and other non-neuronal cells in a ganglioside-independent manner. Gangliosides 270-281 fibronectin 1 Homo sapiens 112-123 11118433-1 2001 Gangliosides GT1b and GD3, components of keratinocyte membranes, inhibit keratinocyte adhesion to fibronectin. Gangliosides 0-12 fibronectin 1 Homo sapiens 98-109 11118433-8 2001 These data provide evidence that highly sialylated gangliosides regulate alpha(5)beta(1)-mediated adhesion of epithelial cells to fibronectin through carbohydrate-carbohydrate interactions between GT1b and the alpha(5) subunit of alpha(5)beta(1) integrin. Gangliosides 51-63 fibronectin 1 Homo sapiens 130-141 7636307-0 1995 Ganglioside GT1b inhibits keratinocyte adhesion and migration on a fibronectin matrix. Gangliosides 0-11 fibronectin 1 Homo sapiens 67-78 7636307-1 1995 Highly sialylated gangliosides have been shown to alter cellular adhesion to a fibronectin matrix. Gangliosides 18-30 fibronectin 1 Homo sapiens 79-90 7636307-3 1995 Ganglioside GT1b significantly prevented attachment of keratinocytes to fibronectin and also detached previously adherent keratinocytes in a concentration-dependent manner without cell toxicity. Gangliosides 0-11 fibronectin 1 Homo sapiens 72-83 7749720-0 1995 Adhesion of human glioma cell lines to fibronectin, laminin, vitronectin and collagen I is modulated by gangliosides in vitro. Gangliosides 104-116 fibronectin 1 Homo sapiens 39-50 6291959-0 1982 Gangliosides as receptors for fibronectin? Gangliosides 0-12 fibronectin 1 Homo sapiens 30-41 6271797-2 1981 We find that purified solubilized gangliosides inhibit fibronectin-mediated hemagglutination, cell spreading, and restoration of a normal morphologic phenotype to transformed cells. Gangliosides 34-46 fibronectin 1 Homo sapiens 55-66 6271797-3 1981 The inhibition is dose-dependent and competitive; hemagglutination by 2 micrograms/ml fibronectin is half-maximally inhibited by less than 1 microM gangliosides. Gangliosides 148-160 fibronectin 1 Homo sapiens 86-97 6271797-8 1981 Our results support the hypothesis that the "receptors" for fibronectin on the cell surface either consist of or contain gangliosides or other negatively charged lipids. Gangliosides 121-133 fibronectin 1 Homo sapiens 60-71 15748213-0 2005 Fibronectin on activated T lymphocytes is bound to gangliosides and is present in detergent insoluble microdomains. Gangliosides 51-63 fibronectin 1 Homo sapiens 0-11 15748213-4 2005 In the present study, we identified gangliosides within the T-cell membrane as specific binding sites for the N-terminal 30 kDa fragment of FN. Gangliosides 36-48 fibronectin 1 Homo sapiens 140-142 12183467-1 2002 Gangliosides are implicated in regulating cell adhesion and migration on fibronectin by binding with the alpha(5) subunit of alpha(5)beta(1) integrin. Gangliosides 0-12 fibronectin 1 Homo sapiens 73-84 12183467-3 2002 Increases in gangliosides GT1b and GD3 inhibited spreading on fibronectin, concurrent with inhibition of Src and focal adhesion kinase. Gangliosides 13-25 fibronectin 1 Homo sapiens 62-73 11577096-1 2001 Ganglioside GT1b inhibits keratinocyte attachment to and migration on a fibronectin matrix by binding to alpha(5)beta(1) and preventing alpha(5)beta(1) interaction with fibronectin. Gangliosides 0-11 fibronectin 1 Homo sapiens 72-83 11577096-1 2001 Ganglioside GT1b inhibits keratinocyte attachment to and migration on a fibronectin matrix by binding to alpha(5)beta(1) and preventing alpha(5)beta(1) interaction with fibronectin. Gangliosides 0-11 fibronectin 1 Homo sapiens 169-180 10951263-0 2000 Gangliosides block keratinocyte binding to fibronectin through carbohydrate-carbohydrate binding to the alpha5 subunit of alpha5beta1 Gangliosides 0-12 fibronectin 1 Homo sapiens 43-54 1679352-7 1991 Gangliosides are non-integrin structures which can bind fibronectin, and there were also qualitative and quantitative differences in ganglioside expression with U937A having two to five times more than U937A/R. Gangliosides 0-12 fibronectin 1 Homo sapiens 56-67