PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11886870-7 2002 We also show by immunofluorescence that in unstimulated cells the EGF receptor is localized in non-caveolar lipid rafts containing the ganglioside GM1 and that patching of these rafts by cholera toxin B-chain causes co-patching of EGF receptors. Gangliosides 135-146 epidermal growth factor Homo sapiens 66-69 11168800-2 2001 Using Scatchard and displacement plots, we have shown that supplemental purified gangliosides decrease the binding of (125)I-labeled epidermal growth factor to keratinocyte-derived SCC12 cells. Gangliosides 81-93 epidermal growth factor Homo sapiens 133-156 11168800-3 2001 Conversely, SCC12 cells transfected with sialidase and thus depleted of gangliosides show increased ligand binding to the epidermal growth factor receptor, which is consistent with their increased proliferation in response to epidermal growth factor and transforming growth factor-alpha, and increased phosphorylation of the epidermal growth factor receptor, and downstream signal transduction pathway components. Gangliosides 72-84 epidermal growth factor Homo sapiens 122-145 8906573-0 1996 Ganglioside effects on basic fibroblast and epidermal growth factor receptors in retinal glial cells. Gangliosides 0-11 epidermal growth factor Homo sapiens 44-67 8721672-3 1996 A single addition of 500 pM bFGF or EGF for 48 h to such cultures led to significant increases in total ganglioside levels of 30-40%. Gangliosides 104-115 epidermal growth factor Homo sapiens 36-39 8469369-2 1993 Basic fibroblast growth factor (bFGF), epidermal growth factor (EGF) but not platelet-derived growth factor (PDGF) induced an increase in the number of cells positive for the ganglioside-recognizing monoclonal antibody, A2B5. Gangliosides 175-186 epidermal growth factor Homo sapiens 39-62 8469369-2 1993 Basic fibroblast growth factor (bFGF), epidermal growth factor (EGF) but not platelet-derived growth factor (PDGF) induced an increase in the number of cells positive for the ganglioside-recognizing monoclonal antibody, A2B5. Gangliosides 175-186 epidermal growth factor Homo sapiens 64-67 19608407-4 2009 Gangliosides also interact laterally in their own membranes, regulating the responsiveness of signaling proteins including the insulin, epidermal growth factor, and vascular endothelial growth factor receptors. Gangliosides 0-12 epidermal growth factor Homo sapiens 136-159 1645342-4 1991 261, 2434-2440) that ganglioside GM3 inhibited epidermal growth factor (EGF)-stimulated phosphorylation of the EGF receptor in Triton X-100-treated preparations of human epidermoid carcinoma (A431) cell membranes. Gangliosides 21-32 epidermal growth factor Homo sapiens 47-70 1645342-4 1991 261, 2434-2440) that ganglioside GM3 inhibited epidermal growth factor (EGF)-stimulated phosphorylation of the EGF receptor in Triton X-100-treated preparations of human epidermoid carcinoma (A431) cell membranes. Gangliosides 21-32 epidermal growth factor Homo sapiens 72-75 1645342-4 1991 261, 2434-2440) that ganglioside GM3 inhibited epidermal growth factor (EGF)-stimulated phosphorylation of the EGF receptor in Triton X-100-treated preparations of human epidermoid carcinoma (A431) cell membranes. Gangliosides 21-32 epidermal growth factor Homo sapiens 111-114 1645342-6 1991 In contrast, a modified ganglioside, de-N-acetyl GM3, enhanced the EGF-dependent tyrosine kinase activity of the EGF receptor. Gangliosides 24-35 epidermal growth factor Homo sapiens 67-70 1645342-6 1991 In contrast, a modified ganglioside, de-N-acetyl GM3, enhanced the EGF-dependent tyrosine kinase activity of the EGF receptor. Gangliosides 24-35 epidermal growth factor Homo sapiens 113-116 1645342-15 1991 We also demonstrate that ganglioside GM3 inhibited EGF-stimulated growth of transfected murine fibroblasts (3T3) that express the gene for human EGF receptor (Velu, T. J., Beguinot, L., Vass, W. C., Zhang, K., Pastan, I., and Lowy, D. R. (1989) J. Gangliosides 25-36 epidermal growth factor Homo sapiens 145-148 1645342-27 1991 These studies indicate that ganglioside GM3, but not its deacetylated analogue, can affect EGF receptor kinase activity in intact membranes. Gangliosides 28-39 epidermal growth factor Homo sapiens 91-94 2519201-3 1989 One is the ganglioside-dependent modulation of autophosphorylation of EGF or PDGF receptors, by which altered the cell growth. Gangliosides 11-22 epidermal growth factor Homo sapiens 70-73 20156584-0 2010 Gangliosides influence EGFR/ErbB2 heterodimer stability but they do not modify EGF-dependent ErbB2 phosphorylation. Gangliosides 0-12 epidermal growth factor Homo sapiens 23-26 20156584-6 2010 Results from co-immunoprecipitation and Western blot experiments have shown that the endogenous ganglioside depletion resulted in the disappearance of SDS-stable EGFR/ErbB2 heterodimers and in the appearance of tyrosine-phosphorylated EGFR also in the absence of EGF stimulation; exogenous GM(3) added in combination with [D]-PDMP reversed both these effects. Gangliosides 96-107 epidermal growth factor Homo sapiens 162-165 20156584-7 2010 In contrast, the tyrosine phosphorylation of ErbB2 in ganglioside-depleted cells occurred only after EGF stimulation. Gangliosides 54-65 epidermal growth factor Homo sapiens 101-104 19641732-3 2009 We have previously used fluorescence lifetime imaging microscopy to study the colocalization of the receptor for EGF with the ganglioside GM1 and the GPI-anchored green fluorescent protein. Gangliosides 126-137 epidermal growth factor Homo sapiens 113-116