PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 1827496-0 1991 Gangliosides inhibit glucosylceramide synthase: a possible role in ganglioside therapy. Gangliosides 0-12 UDP-glucose ceramide glucosyltransferase Mus musculus 21-46 1827496-0 1991 Gangliosides inhibit glucosylceramide synthase: a possible role in ganglioside therapy. Gangliosides 67-78 UDP-glucose ceramide glucosyltransferase Mus musculus 21-46 31168055-1 2020 BACKGROUND: Glucosylceramide synthase (GCS; gene: UDP-glucose:ceramide glucosyltransferase (Ugcg))-derived gangliosides comprise a specific class of lipids in the plasma membrane that modulate the activity of transmembrane receptors. Gangliosides 107-119 UDP-glucose ceramide glucosyltransferase Mus musculus 12-37 35105352-0 2022 Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer"s disease. Gangliosides 45-56 UDP-glucose ceramide glucosyltransferase Mus musculus 0-25 31168055-1 2020 BACKGROUND: Glucosylceramide synthase (GCS; gene: UDP-glucose:ceramide glucosyltransferase (Ugcg))-derived gangliosides comprise a specific class of lipids in the plasma membrane that modulate the activity of transmembrane receptors. Gangliosides 107-119 UDP-glucose ceramide glucosyltransferase Mus musculus 50-90 31168055-1 2020 BACKGROUND: Glucosylceramide synthase (GCS; gene: UDP-glucose:ceramide glucosyltransferase (Ugcg))-derived gangliosides comprise a specific class of lipids in the plasma membrane that modulate the activity of transmembrane receptors. Gangliosides 107-119 UDP-glucose ceramide glucosyltransferase Mus musculus 92-96 23554574-4 2013 As a major mechanism of central nervous system (CNS) metabolic control, we demonstrate that GCS-derived gangliosides interacting with leptin receptors (ObR) in the neuronal membrane modulate leptin-stimulated formation of signaling metabolites in hypothalamic neurons. Gangliosides 104-116 UDP-glucose ceramide glucosyltransferase Mus musculus 92-95 27639375-4 2016 We found that inhibition of glucosylceramide synthase (GCS), the key enzyme of ganglioside biosynthesis, increases viability of cortical neurons in 5xFAD mice, as well as in cultured neurons exposed to oligomeric amyloid-beta-derived diffusible ligands (ADDLs). Gangliosides 79-90 UDP-glucose ceramide glucosyltransferase Mus musculus 55-58 29973867-4 2018 The enzyme glucosylceramide synthase (GCS) catalyzes the rate-limiting step in the biosynthesis of these gangliosides. Gangliosides 105-117 UDP-glucose ceramide glucosyltransferase Mus musculus 11-36 29973867-4 2018 The enzyme glucosylceramide synthase (GCS) catalyzes the rate-limiting step in the biosynthesis of these gangliosides. Gangliosides 105-117 UDP-glucose ceramide glucosyltransferase Mus musculus 38-41 27639375-4 2016 We found that inhibition of glucosylceramide synthase (GCS), the key enzyme of ganglioside biosynthesis, increases viability of cortical neurons in 5xFAD mice, as well as in cultured neurons exposed to oligomeric amyloid-beta-derived diffusible ligands (ADDLs). Gangliosides 79-90 UDP-glucose ceramide glucosyltransferase Mus musculus 28-53 26038579-3 2015 Lipid microdomains contain large quantities of cholesterol and glycosphingolipids, including glucosylceramide synthase (GCS) (gene Ugcg)-derived gangliosides. Gangliosides 145-157 UDP-glucose ceramide glucosyltransferase Mus musculus 93-118 26038579-3 2015 Lipid microdomains contain large quantities of cholesterol and glycosphingolipids, including glucosylceramide synthase (GCS) (gene Ugcg)-derived gangliosides. Gangliosides 145-157 UDP-glucose ceramide glucosyltransferase Mus musculus 120-123 23554574-7 2013 Recombinant adeno-associated virus (rAAV)-mediated Ugcg delivery to the arcuate nucleus (Arc) significantly ameliorated obesity, specifying gangliosides as seminal components for hypothalamic regulation of body energy homeostasis. Gangliosides 140-152 UDP-glucose ceramide glucosyltransferase Mus musculus 51-55 19745600-4 2009 HPTLC/immunofluorescence analyses of shRNA- transfected mESCs revealed that treatment with Ugcg-shRNA decreased expression of major gangliosides, GM3 and GD3. Gangliosides 132-144 UDP-glucose ceramide glucosyltransferase Mus musculus 91-95 21394236-4 2010 For example, the small molecule inhibition of glucosylceramide synthase by miglustat limits ganglioside accumulation and is now the only approved treatment of Niemann-Pick type C. In addition, 2-hydroxypropyl-B-cyclodextrin, a lipid chelator, relieves the lysosomal to endoplasmic reticulum blockage and markedly increases the life expectancy of the murine model. Gangliosides 92-103 UDP-glucose ceramide glucosyltransferase Mus musculus 46-71 11971858-4 2002 Antisense transfection inhibited the synthesis of the direct product of glucosylceramide synthase, glucosylceramide, and consequently G(M3) ganglioside, by MEB4 cells, reducing the concentration of G(M3) in the transfectants by up to 58%. Gangliosides 140-151 UDP-glucose ceramide glucosyltransferase Mus musculus 72-97 11971858-7 2002 These findings demonstrate that stable transfection of glucosylceramide synthase antisense reduces cellular glycosphingolipid levels and reduces tumorigenicity, providing further experimental support for an enhancing role of gangliosides in tumor formation. Gangliosides 225-237 UDP-glucose ceramide glucosyltransferase Mus musculus 55-80 9809988-7 1998 DL-PDMP is a potent inhibitor of glucosylceramide synthase, resulting in inhibition of the synthesis and shedding of gangliosides. Gangliosides 117-129 UDP-glucose ceramide glucosyltransferase Mus musculus 33-58