PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23685028-0 2013 Interconversion of ketoprofen recognition in firefly luciferase-catalyzed enantioselective thioesterification reaction using from Pylocoeria miyako (PmL) and Hotaria parvura (HpL) just by mutating two amino acid residues. Ketoprofen 19-29 PML nuclear body scaffold Homo sapiens 149-152 23685028-1 2013 We identified the critical amino acid residues for substrate recognition using two firefly luciferases from Pylocoeria miyako (PmL) and Hotaria parvura (HpL), as these two luciferase enzymes exhibit different activities toward ketoprofen. Ketoprofen 227-237 PML nuclear body scaffold Homo sapiens 127-130 23685028-3 2013 By comparing the amino acid sequences around the active site, we identified two residues (I350 and M397 in PmL and F351 and S398 in HpL) that were different between the two enzymes, and the replacement of these amino acids resulted in changing the ketoprofen recognition pattern. Ketoprofen 248-258 PML nuclear body scaffold Homo sapiens 107-110