PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
8951933-0	1996	Ketoprofen produces profound inhibition of spinal c-Fos protein expression resulting from an inflammatory stimulus but not from noxious heat.	Ketoprofen	0-10	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	50-55	
8951933-1	1996	This study assesses the anti-inflammatory/analgesic effects of ketoprofen a non-steroidal anti-inflammatory drug, using the method of c-Fos immunoreactivity at the spinal cord level in two models of noxious stimulation: carrageenan-induced inflammatory pain or acute noxious heat.	Ketoprofen	63-73	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	134-139	
8951933-6	1996	The effect of ketoprofen was significantly greater on the number of c-Fos-LI neurons in deep, as compared to superficial, laminae.	Ketoprofen	14-24	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	68-73	
8951933-7	1996	Furthermore, the dose-dependent effects of ketoprofen on the carrageenan-induced spinal c-Fos protein expression and both the paw and ankle oedema were correlated.	Ketoprofen	43-53	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	88-93	
8951933-8	1996	Oral pre-administration of ketoprofen (20 mg/kg) produced the blockage of development of the carrageenan-induced spinal c-Fos protein expression (65 +/- 3% diminution of total number of c-Fos-LI neurons per L4-L5 section) and peripheral oedema (20 +/- 3% and 59 +/- 10% diminution of paw and ankle oedema, respectively).	Ketoprofen	27-37	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	120-125	
8951933-8	1996	Oral pre-administration of ketoprofen (20 mg/kg) produced the blockage of development of the carrageenan-induced spinal c-Fos protein expression (65 +/- 3% diminution of total number of c-Fos-LI neurons per L4-L5 section) and peripheral oedema (20 +/- 3% and 59 +/- 10% diminution of paw and ankle oedema, respectively).	Ketoprofen	27-37	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	186-191	
8951933-11	1996	The method of c-Fos protein-like immunoreactivity revealed ketoprofen to be more potent in comparison to members of other families of non-steroidal anti-inflammatory drugs, previously studied in the same experimental conditions of carrageenan-induced inflammatory pain.	Ketoprofen	59-69	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-19	
19463915-6	2009	Post-treatment with ketoprofen produced inhibition of c-Fos but parecoxib did not have any significant effect.	Ketoprofen	20-30	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	54-59	
19463915-8	2009	Paradoxically, pre-treatment with ketoprofen produced a greater inhibition of c-Fos expression than with parecoxib, in all lamina of ipsilateral dorsal horn of the lumbar spinal cord.	Ketoprofen	34-44	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	78-83