PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3455050-6 1987 In compounds with other substituents that promote activity, C-6 alpha substitution with -CH3, -Cl, or -Br strongly enhances activity; -F, -OCH3, carbonyl, or the unsubstituted compound promotes weak binding; and -OC2H5, -OAc, -OCOOCH3, or -OH eliminates binding activity. SDZ 33-243 221-224 complement C6 Canis lupus familiaris 60-63