PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28137608-0	2017	Silymarin protects against acrylamide-induced neurotoxicity via Nrf2 signalling in PC12 cells.	Silymarin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	64-68	
28648817-0	2017	Modulatory effect of silymarin on nuclear factor-erythroid-2-related factor 2 regulated redox status, nuclear factor-kappaB mediated inflammation and apoptosis in experimental gastric ulcer.	Silymarin	21-30	NFE2 like bZIP transcription factor 2	Rattus norvegicus	34-77	
32133068-11	2019	Silymarin ameliorated the histopathological lung injury with further up-regulation of Nrf-2 and HO-1 mRNA and decreased the inflammatory and fibrotic parameters together with up-regulation of the anti-apoptotic and the proliferation parameters.	Silymarin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	86-91	
32133068-12	2019	Conclusion: The protective effect of silymarin against ALI is mediated by Nrf-2/HO-1 pathway with subsequent antioxidant, anti-inflammatory, antiapoptotic, and proliferating activities.	Silymarin	37-46	NFE2 like bZIP transcription factor 2	Rattus norvegicus	74-79	
28137608-6	2017	To identify a potential mechanism for SM-induced protection, we measured the mRNA and protein expression levels of Nrf2 and its downstream target antioxidants glutathione peroxidase (Gpx), glutamate cysteine ligase catalytic subunit (GCLC) and glutamate cysteine ligase modifier subunit (GCLM) by quantitative real-time PCR and Western blot, respectively.	Silymarin	38-40	NFE2 like bZIP transcription factor 2	Rattus norvegicus	115-119	
28137608-2	2017	Here, we investigated the protective effect of SM against acrylamide (AA)-induced neurotoxicity, mainly caused by oxidative stress, via activation of the nuclear transcription factor E2-related factor 2 (Nrf2) signalling pathway in PC12 cells.	Silymarin	47-49	NFE2 like bZIP transcription factor 2	Rattus norvegicus	204-208	
26173462-10	2015	However, the addition of Nrf2 siRNA reduced the expression of Nrf2-mediated antioxidant protein HO-1 and thus reversed the protective effects of silymarin against oxidative stress and inflammatory response.	Silymarin	145-154	NFE2 like bZIP transcription factor 2	Rattus norvegicus	25-29	
26173462-10	2015	However, the addition of Nrf2 siRNA reduced the expression of Nrf2-mediated antioxidant protein HO-1 and thus reversed the protective effects of silymarin against oxidative stress and inflammatory response.	Silymarin	145-154	NFE2 like bZIP transcription factor 2	Rattus norvegicus	62-66	
22710359-10	2012	Silymarin increased the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and decreased tumor necrosis factor (TNF)-alpha mRNA expression in the liver.	Silymarin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	49-92	
22710359-10	2012	Silymarin increased the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and decreased tumor necrosis factor (TNF)-alpha mRNA expression in the liver.	Silymarin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	94-98	
35128959-0	2022	Silymarin protects the rats against paraquat-induced acute kidney injury via Nrf2.	Silymarin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	77-81	
35128959-8	2022	It was found that silymarin treatment improved renal function, decreased injury score in kidney tissues, and inhibited the apoptosis and oxidative stress in PQ-induced acute kidney injury through the activating the signaling pathway of Nrf2 and promoting its nuclear translocation.	Silymarin	18-27	NFE2 like bZIP transcription factor 2	Rattus norvegicus	236-240	
26173462-0	2015	Silymarin attenuates paraquat-induced lung injury via Nrf2-mediated pathway in vivo and in vitro.	Silymarin	0-9	NFE2 like bZIP transcription factor 2	Rattus norvegicus	54-58	
26173462-9	2015	Meanwhile, treatment with silymarin upregulated the levels of nuclear factor-erythroid-2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase-1(NQO1).	Silymarin	26-35	NFE2 like bZIP transcription factor 2	Rattus norvegicus	62-105	
26173462-9	2015	Meanwhile, treatment with silymarin upregulated the levels of nuclear factor-erythroid-2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase-1(NQO1).	Silymarin	26-35	NFE2 like bZIP transcription factor 2	Rattus norvegicus	107-111	
33811899-0	2021	Chlorogenic acid, quercetin, coenzyme Q10 and silymarin modulate Keap1-Nrf2/heme oxygenase-1 signaling in thioacetamide-induced acute liver toxicity.	Silymarin	46-55	NFE2 like bZIP transcription factor 2	Rattus norvegicus	71-75	
33811899-2	2021	We investigated the effect of chlorogenic acid (CGA), quercetin (Qt), coenzyme Q10 (Q10) and silymarin on the expression of Keap1/Nrf2 complex and its downstream target; heme oxygenase 1 (HO-1) as well as inflammation and apoptosis in an acute liver toxicity model induced by thioacetamide (TAA).	Silymarin	93-102	NFE2 like bZIP transcription factor 2	Rattus norvegicus	130-134	
33811899-13	2021	SIGNIFICANCE: CGA, Qt, Q10 and silymarin protect against TAA-induced acute liver toxicity via antioxidant, anti-inflammatory, anti-apoptotic activities and regulating Keap1-Nrf2/HO-1 expression.	Silymarin	31-40	NFE2 like bZIP transcription factor 2	Rattus norvegicus	173-177