PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8514779-0 1993 Tyrosyl phosphorylation and growth factor receptor association of the human corkscrew homologue, SH-PTP2. cyclo(tyrosyl-tyrosyl) 0-7 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 97-104 8622663-3 1996 An SHPTP2 mutant with both C-terminal tyrosyl phosphorylation sites converted to phenylalanine (PTP2YF) was also without effect; moreover, PTP2YF rescued PTP2CS-induced inhibition of EGF-induced Elk-1 transactivation. cyclo(tyrosyl-tyrosyl) 38-45 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 3-9 15133037-6 2004 In response to epidermal growth factor (EGF), SHP-2 associates via its SH2 domains with tyrosyl-phosphorylated MVP. cyclo(tyrosyl-tyrosyl) 88-95 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 46-51 25039348-1 2014 Src homology 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2), encoded by the human PTPN11 gene, is a ubiquitously expressed protein tyrosine phosphatase (PTP) that consists of two tandem Src homology (SH2) domains (N-SH2 and C-SH2), a PTP catalytic domain, and a C-terminal tail with tyrosyl phosphorylation sites. cyclo(tyrosyl-tyrosyl) 293-300 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 64-68 25039348-1 2014 Src homology 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2), encoded by the human PTPN11 gene, is a ubiquitously expressed protein tyrosine phosphatase (PTP) that consists of two tandem Src homology (SH2) domains (N-SH2 and C-SH2), a PTP catalytic domain, and a C-terminal tail with tyrosyl phosphorylation sites. cyclo(tyrosyl-tyrosyl) 293-300 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 92-98 20473329-7 2010 Interestingly, SIRPalpha1 overexpression differentially modulated SHP-2 phosphorylation at tyrosyl 542 and 580 residues, which may regulate Erk1/2 activity and the EGFRvIII phenotype. cyclo(tyrosyl-tyrosyl) 91-98 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 66-71 15133037-7 2004 MVP also interacts with the activated form of the extracellular-regulated kinases (Erks) in response to EGF and a constitutive complex between tyrosyl-phosphorylated MVP, SHP-2, and the Erks was detected in MCF-7 breast cancer cells. cyclo(tyrosyl-tyrosyl) 143-150 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 171-176 15133037-10 2004 The regulation of MVP tyrosyl phosphorylation by SHP-2 may play an important role in cell survival signaling. cyclo(tyrosyl-tyrosyl) 22-29 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 49-54 11997521-5 2002 In this study, we show that stimulation of C2C12 myoblasts with FGF-2 induces SHP-2 complex formation with tyrosyl-phosphorylated FGFR substrate 2 alpha (FRS-2 alpha). cyclo(tyrosyl-tyrosyl) 107-114 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 78-83 14967142-6 2004 In Shp2-deficient cells, SFK inhibitory C-terminal tyrosines are hyperphosphorylated, and the tyrosyl phosphorylation of multiple SFK substrates, including Plcgamma1, is decreased. cyclo(tyrosyl-tyrosyl) 94-101 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 3-7 12923167-0 2003 Tyrosyl phosphorylation of Shp2 is required for normal ERK activation in response to some, but not all, growth factors. cyclo(tyrosyl-tyrosyl) 0-7 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 27-31 12923167-2 2003 In fibroblasts, Shp2 undergoes phosphorylation at two C-terminal tyrosyl residues in response to some (fibroblast growth factor and platelet-derived growth factor (PDGF)) but not all (epidermal growth factor and insulin-like growth factor) growth factors. cyclo(tyrosyl-tyrosyl) 65-72 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 16-20 12923167-7 2003 Immunoblot analyses confirm that Tyr-542 and Tyr-580 are the major sites of Shp2 tyrosyl phosphorylation and that Tyr-542 is the major Grb2 binding site. cyclo(tyrosyl-tyrosyl) 81-88 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 76-80 12923167-8 2003 However, studies with antibodies specific for individual Shp2 phosphorylation sites reveal unexpected complexity in the mechanism of Shp2 tyrosyl phosphorylation by different receptor tyrosine kinases. cyclo(tyrosyl-tyrosyl) 138-145 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 57-61 12923167-8 2003 However, studies with antibodies specific for individual Shp2 phosphorylation sites reveal unexpected complexity in the mechanism of Shp2 tyrosyl phosphorylation by different receptor tyrosine kinases. cyclo(tyrosyl-tyrosyl) 138-145 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 133-137 15169898-8 2004 Moreover, overexpression of a catalytically inactive mutant of SHP-2 inhibited p190-B RhoGAP tyrosyl dephosphorylation, RhoA activity, and myogenesis. cyclo(tyrosyl-tyrosyl) 93-100 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 63-68 12217400-6 2002 More recent results established that MAFA"s inhibitory action involves at least two different enzymes: Following the tyrosyl-phosphorylation of MAFA ITIM by the PTK Lyn, two phosphatases SHIP and SHP2 are recruited to it at the plasma membrane where they propagate the inhibitory signals. cyclo(tyrosyl-tyrosyl) 117-124 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 196-200 11997521-6 2002 Both the catalytic activity and, to a much lesser extent, the Grb2 binding-tyrosyl phosphorylation sites of SHP-2 are required for maximal FGF-2-induced Erk activity and Elk-1 transactivation. cyclo(tyrosyl-tyrosyl) 75-82 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 108-113 11997521-9 2002 The constitutively active mutant of SHP-2 induces hyper-tyrosyl phosphorylation of FRS-2 alpha but fails to stimulate or potentiate either FGF-2-induced Erk activation or Elk-1 transactivation. cyclo(tyrosyl-tyrosyl) 56-63 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 36-41 10842184-5 2000 However, when the C-terminal 30 amino acids of SIRPalpha1 containing the proline-rich region and tyrosine 495 are deleted, tyrosyl phosphorylation of SIRPalpha1 by JAK2 and association of SHP-2 with SIRPalpha1 are reduced. cyclo(tyrosyl-tyrosyl) 123-130 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 188-193 11493654-4 2001 We show that in C2C12 myoblasts, SHP-2 becomes upregulated early on during myogenesis and associates with a 120 kDa tyrosyl-phosphorylated complex. cyclo(tyrosyl-tyrosyl) 116-123 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 33-38 10082587-13 1999 Integrin-induced activation of Src family PTKs, tyrosyl phosphorylation of several focal adhesion proteins, MAPK activation, and the ability to spread on fibronectin were defective in SHP-2 mutant fibroblasts but were restored upon SHP-2 expression. cyclo(tyrosyl-tyrosyl) 48-55 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 184-189 10542295-7 1999 It was correlated with the tyrosyl phosphorylation of the SIRPalpha chimera and the recruitment of SHP-1 and SHP-2. cyclo(tyrosyl-tyrosyl) 27-34 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 109-114 10651806-4 2000 Both tyrosyl phosphorylated and thiophosphorylated mast cell function-associated antigen peptides bound the src homology domain 2 (SH2)-containing tyrosine phosphatases-1 (SHP-1), -2 (SHP-2) and inositol 5"-phosphatase (SHIP), though with different efficiencies. cyclo(tyrosyl-tyrosyl) 5-12 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 184-189 10082587-14 1999 Our data suggest a positive-feedback model in which, upon integrin engagement, basal levels of c-Src activity catalyze the tyrosyl phosphorylation of SHPS-1, thereby recruiting SHP-2 to the plasma membrane, where, perhaps by further activating Src PTKs, SHP-2 transduces positive signals for downstream events such as MAPK activation and cell shape changes. cyclo(tyrosyl-tyrosyl) 123-130 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 177-182 10082587-14 1999 Our data suggest a positive-feedback model in which, upon integrin engagement, basal levels of c-Src activity catalyze the tyrosyl phosphorylation of SHPS-1, thereby recruiting SHP-2 to the plasma membrane, where, perhaps by further activating Src PTKs, SHP-2 transduces positive signals for downstream events such as MAPK activation and cell shape changes. cyclo(tyrosyl-tyrosyl) 123-130 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 254-259 9885561-3 1998 Upon cytokine, growth factor, or antigen receptor stimulation, p97 becomes tyrosyl phosphorylated and associates with several SH2 domain-containing proteins, including SHP2. cyclo(tyrosyl-tyrosyl) 75-82 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 168-172 9670943-6 1998 BCR stimulation induced the association of SHP-2 with a single major tyrosyl-phosphorylated molecule (pp120) that had an apparent molecular mass of 120 kDa. cyclo(tyrosyl-tyrosyl) 69-76 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 43-48 9670943-8 1998 Analysis of the subcellular localization of pp120 showed that the complex of SHP-2 and tyrosyl-phosphorylated p120 occurs predominantly in the cytosol. cyclo(tyrosyl-tyrosyl) 87-94 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 77-82 9670943-9 1998 Furthermore, the binding of the two molecules was mediated by the interaction of tyrosyl-phosphorylated p120 with the SHP-2 N-terminal SH2 domain. cyclo(tyrosyl-tyrosyl) 81-88 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 118-123 9507023-0 1998 Growth hormone regulation of SIRP and SHP-2 tyrosyl phosphorylation and association. cyclo(tyrosyl-tyrosyl) 44-51 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 38-43 9195950-5 1997 We identified two novel tyrosyl-phosphorylated proteins associated with SHP-2 in hematopoietic cells. cyclo(tyrosyl-tyrosyl) 24-31 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 72-77 9507023-3 1998 In 3T3-F442A fibroblasts, GH rapidly stimulates tyrosyl phosphorylation of both SIRPalpha and SHP-2 and enhances association of SHP-2 with SIRPalpha. cyclo(tyrosyl-tyrosyl) 48-55 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 94-99 9507023-5 1998 LIF does not stimulate tyrosyl phosphorylation of SIRPalpha but stimulates greater tyrosyl phosphorylation of SHP-2 than GH. cyclo(tyrosyl-tyrosyl) 83-90 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 110-115