PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7651366-1	1995	The metabolism of 5,10-dideazatetrahydrofolate (DDATHF [lometrexol]) to polyglutamate derivatives by folylpoly-gamma-glutamate synthetase (FPGS) plays a central role in the activity of this compound as an antineoplastic agent.	lometrexol	18-46	folylpolyglutamate synthase	Homo sapiens	101-137	
10598554-4	1999	Using FPGS from two different species, Km values below 2 micromol/L and high relative first order rate constants, k" (Vmax/Km) of 6.4 and 13.7 compared with another substrate, lometrexol, were obtained.	lometrexol	176-186	folylpolyglutamate synthase	Homo sapiens	6-10	
7651366-1	1995	The metabolism of 5,10-dideazatetrahydrofolate (DDATHF [lometrexol]) to polyglutamate derivatives by folylpoly-gamma-glutamate synthetase (FPGS) plays a central role in the activity of this compound as an antineoplastic agent.	lometrexol	18-46	folylpolyglutamate synthase	Homo sapiens	139-143	
7651366-1	1995	The metabolism of 5,10-dideazatetrahydrofolate (DDATHF [lometrexol]) to polyglutamate derivatives by folylpoly-gamma-glutamate synthetase (FPGS) plays a central role in the activity of this compound as an antineoplastic agent.	lometrexol	48-54	folylpolyglutamate synthase	Homo sapiens	101-137	
7651366-1	1995	The metabolism of 5,10-dideazatetrahydrofolate (DDATHF [lometrexol]) to polyglutamate derivatives by folylpoly-gamma-glutamate synthetase (FPGS) plays a central role in the activity of this compound as an antineoplastic agent.	lometrexol	48-54	folylpolyglutamate synthase	Homo sapiens	139-143	
7651366-1	1995	The metabolism of 5,10-dideazatetrahydrofolate (DDATHF [lometrexol]) to polyglutamate derivatives by folylpoly-gamma-glutamate synthetase (FPGS) plays a central role in the activity of this compound as an antineoplastic agent.	lometrexol	56-66	folylpolyglutamate synthase	Homo sapiens	101-137	
7651366-1	1995	The metabolism of 5,10-dideazatetrahydrofolate (DDATHF [lometrexol]) to polyglutamate derivatives by folylpoly-gamma-glutamate synthetase (FPGS) plays a central role in the activity of this compound as an antineoplastic agent.	lometrexol	56-66	folylpolyglutamate synthase	Homo sapiens	139-143	
7651366-9	1995	After correction for the intrinsic inhibitory activity of the parent DDATHF analog as an inhibitor of the target enzyme, the first-order rate constants for FPGS were found to be predictive of the potency of tumor cell growth inhibition for most of the compounds in this structural series.	lometrexol	69-75	folylpolyglutamate synthase	Homo sapiens	156-160	
8144562-3	1994	After short term exposure to DATHF, cells expressing higher levels of human FPGS were more sensitive to the drug while cells expressing low levels were resistant.	lometrexol	29-34	folylpolyglutamate synthase	Homo sapiens	76-80	
8144562-4	1994	Cells expressing E. coli FPGS solely in the cytosol were resistant to DATHF and accumulated only low levels of the drug.	lometrexol	70-75	folylpolyglutamate synthase	Homo sapiens	25-29