PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18723763-2 2008 The present study tested a hypothesis that a special lipid-raft (LR) form, ceramide-enriched lipid platform, contributes to CD38 activation to produce cADPR in response to muscarinic type 1 (M(1)) receptor stimulation in bovine coronary arterial myocytes (CAMs). cams 256-260 CD38 molecule Bos taurus 124-128 18723763-7 2008 In floated detergent-resistant membrane fractions, CD38 significantly increased in LR fractions of CAMs treated by Oxo. cams 99-103 CD38 molecule Bos taurus 51-55 18723763-10 2008 These results provide the first evidence that the formation of ceramide-enriched lipid macrodomains is crucial for Oxo-induced activation of CD38 to produce cADPR in CAMs, and these lipid macrodomains mediate transmembrane signaling of M(1) receptor activation to produce second messenger cADPR. cams 166-170 CD38 molecule Bos taurus 141-145