PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9374724-4	1997	We demonstrate that the NO donor spermine NONOate (SNN) increases steady-state levels of HO-1 mRNA in aortic vascular smooth muscle cells (aSMC) in both a time- and dose-dependent manner.	spermine nitric oxide complex	33-49	heme oxygenase 1	Homo sapiens	89-93	
9374724-4	1997	We demonstrate that the NO donor spermine NONOate (SNN) increases steady-state levels of HO-1 mRNA in aortic vascular smooth muscle cells (aSMC) in both a time- and dose-dependent manner.	spermine nitric oxide complex	51-54	heme oxygenase 1	Homo sapiens	89-93	
9374724-8	1997	The antioxidant N-acetyl-L-cysteine markedly inhibited SNN-induced HO-1 mRNA expression, whereas peroxynitrite did not induce HO-1 expression in aSMC.	spermine nitric oxide complex	55-58	heme oxygenase 1	Homo sapiens	67-71	
18178725-4	2008	Induction of HO-1 was associated with an attenuation of pulmonary arterial relaxation to the NO-donor spermine-NONOate.	spermine nitric oxide complex	102-118	heme oxygenase 1	Homo sapiens	13-17	
18178725-8	2008	However, the increase in activity seen in the presence of 1 microM spermine-NONOate was attenuated in homogenates obtained from arteries with increased HO-1.	spermine nitric oxide complex	67-83	heme oxygenase 1	Homo sapiens	152-156	
15740980-8	2005	When the GSH-depleted or BSO-pretreated macrophages were exposed to NO, delivered either exogenously from spermine NONOate or endogenously from LPS-derived elevation of iNOS, super-induction of HO-1 was observed.	spermine nitric oxide complex	106-122	heme oxygenase 1	Homo sapiens	194-198	
15740980-7	2005	Alternatively, when the macrophages were exposed to spermine NONOate, an exogenous NO-donor, HO-1, was induced also.	spermine nitric oxide complex	52-68	heme oxygenase 1	Homo sapiens	93-97	
11287117-1	2001	Unstimulated RAW 264.7 macrophages express negligible heme oxygenase-1 (HO-1) protein but incubation with the nitric oxide (NO) donor spermine nonoate (SPNO) induced HO-1 and weakly cyclo-oxygenase-2 (COX-2) protein.	spermine nitric oxide complex	134-150	heme oxygenase 1	Homo sapiens	54-70	
12112002-2	2002	Here we show that NO donors including sodium nitroprusside (SNP) and spermine nonoate (SP-NO), and PGE(2) significantly stimulate HO-1 expression in RAW264.7 macrophages, associated with alternative induction on NO and PGE(2) in medium, respectively.	spermine nitric oxide complex	69-85	heme oxygenase 1	Homo sapiens	130-134	
12878207-7	2003	Pretreatment with N-acetylcysteine, PD 98059, and SB 203580 decreased HO-1 upregulation in spermine NONOate-treated cells.	spermine nitric oxide complex	91-107	heme oxygenase 1	Homo sapiens	70-74	
11287117-1	2001	Unstimulated RAW 264.7 macrophages express negligible heme oxygenase-1 (HO-1) protein but incubation with the nitric oxide (NO) donor spermine nonoate (SPNO) induced HO-1 and weakly cyclo-oxygenase-2 (COX-2) protein.	spermine nitric oxide complex	134-150	heme oxygenase 1	Homo sapiens	72-76	
11287117-1	2001	Unstimulated RAW 264.7 macrophages express negligible heme oxygenase-1 (HO-1) protein but incubation with the nitric oxide (NO) donor spermine nonoate (SPNO) induced HO-1 and weakly cyclo-oxygenase-2 (COX-2) protein.	spermine nitric oxide complex	134-150	heme oxygenase 1	Homo sapiens	166-170	
11287117-1	2001	Unstimulated RAW 264.7 macrophages express negligible heme oxygenase-1 (HO-1) protein but incubation with the nitric oxide (NO) donor spermine nonoate (SPNO) induced HO-1 and weakly cyclo-oxygenase-2 (COX-2) protein.	spermine nitric oxide complex	152-156	heme oxygenase 1	Homo sapiens	54-70	
11287117-1	2001	Unstimulated RAW 264.7 macrophages express negligible heme oxygenase-1 (HO-1) protein but incubation with the nitric oxide (NO) donor spermine nonoate (SPNO) induced HO-1 and weakly cyclo-oxygenase-2 (COX-2) protein.	spermine nitric oxide complex	152-156	heme oxygenase 1	Homo sapiens	72-76	
11287117-1	2001	Unstimulated RAW 264.7 macrophages express negligible heme oxygenase-1 (HO-1) protein but incubation with the nitric oxide (NO) donor spermine nonoate (SPNO) induced HO-1 and weakly cyclo-oxygenase-2 (COX-2) protein.	spermine nitric oxide complex	152-156	heme oxygenase 1	Homo sapiens	166-170	
11287117-3	2001	Cells incubated with SPNO showed a strong increase in HO-1 mRNA levels after 4 h with a significant potentiation in the presence of SC58125, which did not modify HO-1 mRNA stability.	spermine nitric oxide complex	21-25	heme oxygenase 1	Homo sapiens	54-58	
11287117-3	2001	Cells incubated with SPNO showed a strong increase in HO-1 mRNA levels after 4 h with a significant potentiation in the presence of SC58125, which did not modify HO-1 mRNA stability.	spermine nitric oxide complex	21-25	heme oxygenase 1	Homo sapiens	162-166	
10780998-5	2000	Incubation of cells with NO donors, spermine nonoate (SPNO) and S-nitroso-N-acetylpenicillamine (SNAP), induced a dose- and time-dependent expression of HO-1 protein.	spermine nitric oxide complex	36-52	heme oxygenase 1	Homo sapiens	153-157	
10780998-5	2000	Incubation of cells with NO donors, spermine nonoate (SPNO) and S-nitroso-N-acetylpenicillamine (SNAP), induced a dose- and time-dependent expression of HO-1 protein.	spermine nitric oxide complex	54-58	heme oxygenase 1	Homo sapiens	153-157	
10780998-8	2000	COX-2 protein was weakly induced by SPNO in basal conditions and in the presence of LPS a synergy for HO-1 and COX-2 protein expression was observed.	spermine nitric oxide complex	36-40	heme oxygenase 1	Homo sapiens	102-106	
10780998-10	2000	Our results indicate that reactive oxygen species participate in the inductive effect of NO donors or LPS on HO-1 expression, whereas endogenous NO production may play a role in the mechanism of the synergy exhibited by SPNO and LPS on HO-1 and COX-2 expression.	spermine nitric oxide complex	220-224	heme oxygenase 1	Homo sapiens	236-240