PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15064242-4 2004 Here we demonstrate using gelatin substrate zymography that high NO concentrations, whether produced endogenously or by NO donor spermine-NONOate or peroxynitrite-generating compound SIN-1, significantly inhibit MMP-9 expression and activation. spermine nitric oxide complex 129-145 matrix metallopeptidase 9 Homo sapiens 212-217 11833938-5 2001 In addition, we demonstrated a positive regulatory role of NO on the activity and protein expression of MMP-2 and MMP-9, because NO donors (NOC-18 and spermine-NONOate) or the NOS substrate (L-arginine) stimulate, whereas NOS inhibitors (N(G)-nitro-L-arginine methyl ester and N(G)-monomethyl-L-arginine) reduce the expression and gelatinolytic activity of MMP-2 and MMP-9 in isolated trophoblast cells. spermine nitric oxide complex 151-167 matrix metallopeptidase 9 Homo sapiens 114-119