histone deacetylase 2 ; Homo sapiens






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1 7844520 Constitutive expression of human cytomegalovirus glycoprotein B (gpUL55) with mutagenized carboxy-terminal hydrophobic domains. J Gen Virol 1995 Jan 3
2 8917507 Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3. Proc Natl Acad Sci U S A 1996 Nov 12 1
3 10958685 Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12. Mol Cell Biol 2000 Sep 1
4 11102443 Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1. J Biol Chem 2001 Mar 2 6
5 11395507 p65-activated histone acetyltransferase activity is repressed by glucocorticoids: mifepristone fails to recruit HDAC2 to the p65-HAT complex. J Biol Chem 2001 Aug 10 2
6 11470869 The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein. Nucleic Acids Res 2001 Aug 1 2
7 11919195 Phosphatase inhibition leads to histone deacetylases 1 and 2 phosphorylation and disruption of corepressor interactions. J Biol Chem 2002 May 31 2
8 11960997 SUMO-1 modification of histone deacetylase 1 (HDAC1) modulates its biological activities. J Biol Chem 2002 Jun 28 3
9 12176973 The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2. J Biol Chem 2002 Sep 27 2
10 12700284 Modulation of histone acetylation by [4-(acetylamino)-N-(2-amino-phenyl) benzamide] in HCT-8 colon carcinoma. Mol Cancer Ther 2003 Apr 1
11 12840003 The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2. EMBO J 2003 Jul 1 4
12 15001333 Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase. Lancet 2004 Feb 28 2
13 15013452 Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration. Biochem Biophys Res Commun 2004 Feb 27 4
14 15043985 Expression and functional characterization of recombinant human HDAC1 and HDAC3. Life Sci 2004 Apr 16 1
15 15107822 Histone deacetylase inhibitors activate INK4d gene through Sp1 site in its promoter. Oncogene 2004 Jul 8 1
16 15120635 DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system. Biochem Biophys Res Commun 2004 May 28 1
17 15456740 Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF-kappaB activation and proinflammatory cytokine release in alveolar epithelial cells. FASEB J 2004 Dec 3
18 15522123 Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation. BMC Biol 2004 Nov 2 1
19 15713621 Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas. Mol Cell Biol 2005 Mar 1
20 15775975 Cell cycle regulation of chromatin at an origin of DNA replication. EMBO J 2005 Apr 6 1
21 16380507 Histone deacetylase 2-mediated deacetylation of the glucocorticoid receptor enables NF-kappaB suppression. J Exp Med 2006 Jan 23 1
22 16458359 Oxidative stress in asthma and COPD: antioxidants as a therapeutic strategy. Pharmacol Ther 2006 Aug 2
23 16473865 Cigarette smoke induces proinflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages. Am J Physiol Lung Cell Mol Physiol 2006 Jul 2
24 16510470 Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression. Am J Physiol Lung Cell Mol Physiol 2006 Aug 2
25 16985053 Valproate inhibition of histone deacetylase 2 affects differentiation and decreases proliferation of endometrial stromal sarcoma cells. Mol Cancer Ther 2006 Sep 2
26 17312152 17beta-estradiol induces IL-1alpha gene expression in rheumatoid fibroblast-like synovial cells through estrogen receptor alpha (ERalpha) and augmentation of transcriptional activity of Sp1 by dissociating histone deacetylase 2 from ERalpha. J Immunol 2007 Mar 1 1
27 17504013 Oxidative stress and steroid resistance in asthma and COPD: pharmacological manipulation of HDAC-2 as a therapeutic strategy. Expert Opin Ther Targets 2007 Jun 3
28 17827154 Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin. J Biol Chem 2007 Nov 9 1
29 17868033 Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors. Biochem J 2008 Jan 15 1
30 17991736 CIITA mediates interferon-gamma repression of collagen transcription through phosphorylation-dependent interactions with co-repressor molecules. J Biol Chem 2008 Jan 18 1
31 18024889 Functional interaction of the human cytomegalovirus IE2 protein with histone deacetylase 2 in infected human fibroblasts. J Gen Virol 2007 Dec 1
32 18059533 Competitive inhibition of histone deacetylase activity by trichostatin A and butyrate. Biochem Cell Biol 2007 Dec 1
33 18193094 Difference between genomic actions of estrogen versus raloxifene in human ovarian cancer cell lines. Oncogene 2008 Apr 24 1
34 18234319 The role of histone deacetylases in asthma and allergic diseases. J Allergy Clin Immunol 2008 Mar 1
35 18316616 Selective inhibition of histone deacetylase 2 silences progesterone receptor-mediated signaling. Cancer Res 2008 Mar 1 2
36 18327875 Modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin. Mol Nutr Food Res 2008 Sep 1
37 18381445 Statins increase p21 through inhibition of histone deacetylase activity and release of promoter-associated HDAC1/2. Cancer Res 2008 Apr 1 2
38 18408217 Lysophosphatidic acid protects cancer cells from histone deacetylase (HDAC) inhibitor-induced apoptosis through activation of HDAC. J Biol Chem 2008 Jun 13 1
39 18413790 MGCD0103, a novel isotype-selective histone deacetylase inhibitor, has broad spectrum antitumor activity in vitro and in vivo. Mol Cancer Ther 2008 Apr 1
40 18421014 Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. Am J Respir Cell Mol Biol 2008 Sep 10
41 18495085 Trichostatin A improves insulin stimulated glucose utilization and insulin signaling transduction through the repression of HDAC2. Biochem Pharmacol 2008 Jul 1 5
42 18766003 In-vivo effects and mechanisms of celecoxib-reduced growth of cyclooxygenase-2 (COX-2)-expressing versus COX-2-deleted human HCC xenografts in nude mice. Anticancer Drugs 2008 Oct 1
43 18834886 An inactivating mutation in HDAC2 leads to dysregulation of apoptosis mediated by APAF1. Gastroenterology 2008 Nov 3
44 18927347 Histone deacetylase 2 is phosphorylated, ubiquitinated, and degraded by cigarette smoke. Am J Respir Cell Mol Biol 2009 Apr 6
45 18951790 SAR profiles of spirocyclic nicotinamide derived selective HDAC1/HDAC2 inhibitors (SHI-1:2). Bioorg Med Chem Lett 2008 Dec 1 2
46 19015960 Heparin-paclitaxel conjugates using mixed anhydride as intermediate: synthesis, influence of polymer structure on drug release, anticoagulant activity and in vitro efficiency. Pharm Res 2009 Apr 2
47 19041327 HDAC2 deacetylates class II transactivator and suppresses its activity in macrophages and smooth muscle cells. J Mol Cell Cardiol 2009 Mar 1
48 19340485 Epigenetic influences on sensory regeneration: histone deacetylases regulate supporting cell proliferation in the avian utricle. J Assoc Res Otolaryngol 2009 Sep 1
49 19410558 Nitration of distinct tyrosine residues causes inactivation of histone deacetylase 2. Biochem Biophys Res Commun 2009 Jul 3 7
50 19411311 Loss of CFTR results in reduction of histone deacetylase 2 in airway epithelial cells. Am J Physiol Lung Cell Mol Physiol 2009 Jul 2