sphingosine-1-phosphate receptor 1 ; Homo sapiens






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1 2160972 An abundant transcript induced in differentiating human endothelial cells encodes a polypeptide with structural similarities to G-protein-coupled receptors. J Biol Chem 1990 Jun 5 2
2 8626678 The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway. J Biol Chem 1996 May 10 2
3 9488656 Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1. Science 1998 Mar 6 2
4 9660876 Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival. J Cell Biol 1998 Jul 13 5
5 9705355 Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist. J Biol Chem 1998 Aug 21 7
6 9765227 EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibition. J Biol Chem 1998 Oct 16 11
7 10051434 Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle. Role of endothelial differentiation gene 1, c-Src tyrosine kinase and phosphoinositide 3-kinase. Biochem J 1999 Mar 15 2
8 10198065 Ligand-induced trafficking of the sphingosine-1-phosphate receptor EDG-1. Mol Biol Cell 1999 Apr 2
9 10381367 EDG3 is a functional receptor specific for sphingosine 1-phosphate and sphingosylphosphorylcholine with signaling characteristics distinct from EDG1 and AGR16. Biochem Biophys Res Commun 1999 Jun 24 1
10 10488065 Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins. J Biol Chem 1999 Sep 24 1
11 10532586 Lysophosphatidic acid as a regulator of endothelial/leukocyte interaction. Lab Invest 1999 Oct 2
12 10555146 Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate. Cell 1999 Oct 29 2
13 10626811 Sphingosine-1-phosphate inhibits motility of human breast cancer cells independently of cell surface receptors. Cancer Res 1999 Dec 15 1
14 10645770 Induction of endothelial cell chemotaxis by sphingosine 1-phosphate and stabilization of endothelial monolayer barrier function by lysophosphatidic acid, potential mediators of hematopoietic angiogenesis. J Hematother Stem Cell Res 1999 Dec 1
15 10794715 Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3. Biochem J 2000 May 15 1
16 10818438 Sphingosine-1-phosphate signaling via the EDG-1 family of G-protein-coupled receptors. Ann N Y Acad Sci 2000 Apr 6
17 10818441 Sphingosine 1-phosphate: a ligand for the EDG-1 family of G-protein-coupled receptors. Ann N Y Acad Sci 2000 Apr 1
18 10833459 Sphingosylphosphorylcholine induces endothelial cell migration and morphogenesis. Biochem Biophys Res Commun 2000 Jun 7 2
19 10880336 Sphingosine 1-phosphate signalling in mammalian cells. Biochem J 2000 Jul 15 1
20 10982820 Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate. J Biol Chem 2000 Dec 15 2
21 11032855 Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest 2000 Oct 1
22 11134047 Sphingosine 1-phosphate protects human umbilical vein endothelial cells from serum-deprived apoptosis by nitric oxide production. J Biol Chem 2001 Apr 6 1
23 11146117 Differential roles of Edg-1 and Edg-5, sphingosine 1-phosphate receptors, in the signaling pathways in C6 glioma cells. Brain Res Mol Brain Res 2000 Dec 28 3
24 11150298 Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins. J Biol Chem 2001 Apr 13 2
25 11160288 Lysophosphatidic acid receptor-selective effects on Jurkat T cell migration through a Matrigel model basement membrane. J Immunol 2001 Feb 15 3
26 11166272 Platelet-released phospholipids link haemostasis and angiogenesis. Cardiovasc Res 2001 Feb 16 1
27 11230698 Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility. Science 2001 Mar 2 1
28 11557736 Role of the sphingosine 1-phosphate receptor EDG-1 in vascular smooth muscle cell proliferation and migration. Circ Res 2001 Sep 14 2
29 11583630 Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis. Mol Cell 2001 Sep 2
30 11604399 A single amino acid determines lysophospholipid specificity of the S1P1 (EDG1) and LPA1 (EDG2) phospholipid growth factor receptors. J Biol Chem 2001 Dec 28 16
31 11705398 Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors. Biochemistry 2001 Nov 20 4
32 11726541 EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration. FASEB J 2001 Dec 2
33 11741892 Dual regulation of EDG1/S1P(1) receptor phosphorylation and internalization by protein kinase C and G-protein-coupled receptor kinase 2. J Biol Chem 2002 Feb 22 4
34 11915349 [N-glycosylation of sphingosine 1-phosphate receptor, Edg-1, and its role on receptor internalization through membrane microdomain]. Tanpakushitsu Kakusan Koso 2002 Mar 1
35 12069805 Sphingosine-1-phosphate and lipid phosphohydrolases. Biochim Biophys Acta 2002 May 23 6
36 12087059 N-glycans of sphingosine 1-phosphate receptor Edg-1 regulate ligand-induced receptor internalization. FASEB J 2002 Jul 12
37 12234605 Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists. Biochem Pharmacol 2002 Oct 15 2
38 12626332 Role of sphingosine-1 phosphate in the enhancement of endothelial barrier integrity by platelet-released products. Am J Physiol Lung Cell Mol Physiol 2003 Jul 1
39 12673948 [Analyses of Ca-related ion channel currents and their involvement in Ca mobilization in smooth muscle and endothelial cells]. Nihon Yakurigaku Zasshi 2003 Mar 1
40 12775579 High-density lipoprotein stimulates endothelial cell migration and survival through sphingosine 1-phosphate and its receptors. Arterioscler Thromb Vasc Biol 2003 Jul 1 1
41 12796504 Sphingosine 1-phosphate in amniotic fluid modulates cyclooxygenase-2 expression in human amnion-derived WISH cells. J Biol Chem 2003 Aug 22 1
42 14688232 Truncation of the N-terminal ectodomain has implications in the N-glycosylation and transport to the cell surface of Edg-1/S1P1 receptor. J Biochem 2003 Nov 6
43 15063151 Atypical cannabinoid stimulates endothelial cell migration via a Gi/Go-coupled receptor distinct from CB1, CB2 or EDG-1. Eur J Pharmacol 2004 Apr 5 2
44 15177461 Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists. Bioorg Med Chem Lett 2004 Jul 5 1
45 15298705 A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor. BMC Biochem 2004 Aug 6 2
46 15618544 Stable knock-down of the sphingosine 1-phosphate receptor S1P1 influences multiple functions of human endothelial cells. Arterioscler Thromb Vasc Biol 2005 Mar 3
47 15710622 Activated protein C mediates novel lung endothelial barrier enhancement: role of sphingosine 1-phosphate receptor transactivation. J Biol Chem 2005 Apr 29 1
48 15733055 Sphingosine 1-phosphate analogue recognition and selectivity at S1P4 within the endothelial differentiation gene family of receptors. Biochem J 2005 Jul 1 3
49 15750791 Roles for N-glycosylation in the dynamics of Edg-1/S1P1 in sphingosine 1-phosphate-stimulated cells. Glycoconj J 2004 6
50 16195373 Regulation of sphingosine 1-phosphate-induced endothelial cytoskeletal rearrangement and barrier enhancement by S1P1 receptor, PI3 kinase, Tiam1/Rac1, and alpha-actinin. FASEB J 2005 Oct 2