folylpolyglutamate synthase ; Homo sapiens






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1 1435744 Determinants of antifolate cytotoxicity: folylpolyglutamate synthetase activity during cellular proliferation and development. Mol Pharmacol 1992 Oct 5
2 1578484 Side chain modified 5-deazafolate and 5-deazatetrahydrofolate analogues as mammalian folylpolyglutamate synthetase and glycinamide ribonucleotide formyltransferase inhibitors: synthesis and in vitro biological evaluation. J Med Chem 1992 May 1 4
3 1835598 Mechanisms of acquired resistance to methotrexate in a human squamous carcinoma cell line of the head and neck, exposed to different treatment schedules. Eur J Cancer 1991 1
4 1867639 In vitro metabolism of 5,8-dideazafolates and 5,8-dideazaisofolates by mammalian folylpoly-gamma-glutamate synthetase. Biochem Pharmacol 1991 Jul 25 2
5 1895294 Folate analogues. 35. Synthesis and biological evaluation of 1-deaza, 3-deaza, and bridge-elongated analogues of N10-propargyl-5,8-dideazafolic acid. J Med Chem 1991 Sep 2
6 2007575 Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines. J Biol Chem 1991 Apr 5 14
7 2168155 Activation of mammalian folylpolyglutamate synthetase by sodium bicarbonate. Arch Biochem Biophys 1990 Sep 12
8 2308134 Synthesis of N-[N-(4-deoxy-4-amino-10-methylpteroyl)-4-fluoroglutamyl]- gamma-glutamate, an unusual substrate for folylpoly-gamma-glutamate synthetase and gamma-glutamyl hydrolase. J Med Chem 1990 Mar 1
9 2448651 Structural requirements for the activity of antifolates as substrates for mammalian folylpolyglutamate synthetase. NCI Monogr 1987 2
10 2448652 Folate analog nonsubstrates and inhibitors of folylpolyglutamate synthetase as potential cancer chemotherapy drugs. NCI Monogr 1987 8
11 2904278 Substrate specificity of mammalian folylpoly-gamma-glutamate synthetase for 5,8-dideazafolates and 5,8-dideaza analogues of aminopterin. Biochim Biophys Acta 1988 Dec 2 3
12 2906805 Dihydrofolate synthetase and folylpolyglutamate synthetase: direct evidence for intervention of acyl phosphate intermediates. Biochemistry 1988 Dec 13 9
13 3190739 Structural specificity of inhibition of human folylpolyglutamate synthetase by ornithine-containing folate analogs. Biochem Pharmacol 1988 Oct 15 14
14 3431589 Synthesis and biologic activity of new side-chain-altered methotrexate and aminopterin analogs with dual inhibitory action against dihydrofolate reductase and folylpolyglutamate synthetase. NCI Monogr 1987 16
15 3466358 Characterization of human folylpolyglutamate synthetase expressed in Chinese hamster ovary cells. Somat Cell Mol Genet 1986 Nov 3
16 3619447 Human liver folylpolyglutamate synthetase: biochemical characterization and interactions with folates and folate antagonists. Arch Biochem Biophys 1987 Aug 1 9
17 3756000 Biosynthesis of polyglutamates of folates. Biochem Cell Biol 1986 Jul 11
18 3807889 Inhibition of human liver folylpolyglutamate synthetase by non-gamma-glutamylatable antifolate analogs. Mol Pharmacol 1987 Jan 6
19 3812977 In situ autoradiographic detection of folylpolyglutamate synthetase activity. Anal Biochem 1986 Nov 1 5
20 3840051 Activation of folypolyglutamate synthetase by pteroic acid. Can J Biochem Cell Biol 1985 Jul 5
21 3873989 Folate analogues as substrates of mammalian folylpolyglutamate synthetase. Cancer Res 1985 Jul 19
22 6577780 Characterization of the function of mammalian folylpolyglutamate synthetase (FPGS). Adv Exp Med Biol 1983 4
23 7517720 Differences in constitutive and post-methotrexate folylpolyglutamate synthetase activity in B-lineage and T-lineage leukemia. Blood 1994 Jul 15 10
24 7562910 Effect of bridge region variation on antifolate and antitumor activity of classical 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines. J Med Chem 1995 Sep 15 1
25 7565626 Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity. Mol Pharmacol 1995 Sep 1
26 7646057 DL-beta,beta-difluoroglutamic acid mediates position-dependent enhancement or termination of pteroylpoly(gamma-glutamate) synthesis catalyzed by folylpolyglutamate synthetase. Arch Biochem Biophys 1995 Aug 20 11
27 7646540 Mechanisms of resistance to N-[5-[N-(3,4-dihydro-2-methyl-4- oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl]-L-glutamic acid (ZD1694), a folate-based thymidylate synthase inhibitor, in the HCT-8 human ileocecal adenocarcinoma cell line. Biochem Pharmacol 1995 Jul 31 1
28 7651366 Substrate specificity of mammalian folylpolyglutamate synthetase for 5,10-dideazatetrahydrofolate analogs. Mol Pharmacol 1995 Aug 10
29 7721888 Upstream organization of and multiple transcripts from the human folylpoly-gamma-glutamate synthetase gene. J Biol Chem 1995 Apr 21 6
30 7865908 Quantitative analysis of folylpolyglutamate synthetase gene expression in tumor tissues by the polymerase chain reaction: marked variation of expression among leukemia patients. Oncol Res 1994 3
31 7890662 Rapid decline in folylpolyglutamate synthetase activity and gene expression during maturation of HL-60 cells. Nature of the effect, impact on folate compound polyglutamate pools, and evidence for programmed down-regulation during maturation. J Biol Chem 1995 Mar 10 8
32 8114682 A strategy for the design of membrane-permeable folypoly-gamma-glutamate synthetase inhibitors: "bay-region"-substituted 2-desamino-2-methyl-5,8-dideazafolate analogs. Mol Pharmacol 1994 Feb 8
33 8144562 Role of folylpolyglutamate synthetase in the metabolism and cytotoxicity of 5-deazaacyclotetrahydrofolate, an anti-purine drug. J Biol Chem 1994 Apr 1 4
34 8217815 Accumulation of 5-methyltetrahydrofolic acid and folylpolyglutamate synthetase expression by mitogen stimulated human lymphocytes. Br J Haematol 1993 Aug 2
35 8255099 Cross-resistance studies of folylpolyglutamate synthetase-deficient, methotrexate-resistant CCRF-CEM human leukemia sublines. Leukemia 1993 Dec 9
36 8408018 Regulation of folate and one-carbon metabolism in mammalian cells. I. Folate metabolism in Chinese hamster ovary cells expressing Escherichia coli or human folylpoly-gamma-glutamate synthetase activity. J Biol Chem 1993 Oct 15 12
37 8408019 Regulation of folate and one-carbon metabolism in mammalian cells. II. Effect of folylpoly-gamma-glutamate synthetase substrate specificity and level on folate metabolism and folylpoly-gamma-glutamate specificity of metabolic cycles of one-carbon metabolism. J Biol Chem 1993 Oct 15 6
38 8408021 Regulation of folate and one-carbon metabolism in mammalian cells. IV. Role of folylpoly-gamma-glutamate synthetase in methotrexate metabolism and cytotoxicity. J Biol Chem 1993 Oct 15 6
39 8521387 Structural organization of the human folypoly-gamma-glutamate synthetase gene: evidence for a single genomic locus. Cancer Res 1995 Dec 15 1
40 8568828 Synthesis and biological evaluation of DL-4,4-difluoroglutamic acid and DL-gamma,gamma-difluoromethotrexate. J Med Chem 1996 Jan 5 8
41 8589057 The stereospecific cytotoxic potency of (6R) and (6S)-5,10- dideazatetrahydrofolate correlates with cellular folylpolyglutamate synthetase levels. Biochimie 1995 1
42 8608962 The influence of drug-exposure conditions on the development of resistance to methotrexate or ZD1694 in cultured human leukaemia cells. Int J Cancer 1996 Mar 28 1
43 8624289 Folate-based thymidylate synthase inhibitors as anticancer drugs. Ann Oncol 1995 Nov 2
44 8662720 Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene. J Biol Chem 1996 May 31 3
45 8691451 Synthesis and biological evaluation of N alpha-(4-amino-4-deoxy-10-methylpteroyl)-DL-4,4-difluoroornithine. J Med Chem 1996 Jun 21 2
46 8740793 Critical factors for optimizing the 5-fluorouracil-folinic acid association in cancer chemotherapy. Ann Oncol 1996 Mar 3
47 8764125 In vitro uptake, anabolism, and cellular retention of 1843U89 and other benzoquinazoline inhibitors of thymidylate synthase. Cancer Res 1996 Jul 15 3
48 8869756 The role of dietary folate in modulation of folate receptor expression, folylpolyglutamate synthetase activity and the efficacy and toxicity of lometrexol. Adv Enzyme Regul 1996 1
49 8907263 Role of folylpolygutamate synthetase (FPGS) in antifolate chemotherapy; a biochemical and clinical update. Leuk Lymphoma 1996 Mar 2
50 8914844 Potent inhibition of human folylpolyglutamate synthetase by suramin. Arch Biochem Biophys 1996 Nov 1 9