5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase ; Homo sapiens






238 Article(s)
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1 1597445 Antifolates induce inhibition of amido phosphoribosyltransferase in leukemia cells. J Biol Chem 1992 Jun 5 4
2 2006182 Methotrexate inhibits neutrophil function by stimulating adenosine release from connective tissue cells. Proc Natl Acad Sci U S A 1991 Mar 15 11
3 2443493 Evidence for direct inhibition of de novo purine synthesis in human MCF-7 breast cells as a principal mode of metabolic inhibition by methotrexate. J Biol Chem 1987 Oct 5 7
4 2521177 Inhibition of glycinamide ribonucleotide formyltransferase and other folate enzymes by homofolate polyglutamates in human lymphoma and murine leukemia cell extracts. Cancer Res 1989 Jan 1 4
5 3366769 Identification and biochemical properties of 10-formyldihydrofolate, a novel folate found in methotrexate-treated cells. J Biol Chem 1988 May 25 5
6 7104299 Direct transfer of one-carbon units in the transformylations of de novo purine biosynthesis. Biochemistry 1982 Jun 8 6
7 7810885 Radioassay of bifunctional 5-aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase by thin-layer chromatography. Anal Biochem 1994 Sep 3
8 7947835 5-Aminoimidazole-4-carboxamide ribotide transformylase-IMP cyclohydrolase from human CCRF-CEM leukemia cells: purification, pH dependence, and inhibitors. Biochemistry 1994 Nov 29 3
9 8412002 Residual adenylosuccinase activities in fibroblasts of adenylosuccinase-deficient children: parallel deficiency with adenylosuccinate and succinyl-AICAR in profoundly retarded patients and non-parallel deficiency in a mildly retarded girl. J Inherit Metab Dis 1993 3
10 9143321 Saccharomyces cerevisiae expresses two genes encoding isozymes of 5-aminoimidazole-4-carboxamide ribonucleotide transformylase. Arch Biochem Biophys 1997 Apr 15 2
11 9378707 Characterization of molecularly cloned human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase. J Biochem 1997 Aug 2
12 9598063 Structure and functional relationships in human pur H. Adv Exp Med Biol 1998 5
13 9762351 Multiple folate enzyme inhibition: mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA). Adv Enzyme Regul 1998 2
14 10548499 The effect of AMP-activated protein kinase and its activator AICAR on the metabolism of human umbilical vein endothelial cells. Biochem Biophys Res Commun 1999 Nov 1
15 10702393 ATIC-ALK: A novel variant ALK gene fusion in anaplastic large cell lymphoma resulting from the recurrent cryptic chromosomal inversion, inv(2)(p23q35). Am J Pathol 2000 Mar 1
16 10801888 Binding of PurH to a muscle-specific splicing enhancer functionally correlates with exon inclusion in vivo. J Biol Chem 2000 Jul 7 1
17 10855951 Effects of methotrexate on nucleotide pools in normal human T cells and the CEM T cell line. Life Sci 2000 4
18 10985775 Human AICAR transformylase: role of the 4-carboxamide of AICAR in binding and catalysis. Biochemistry 2000 Sep 19 11
19 11016448 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) inhibits insulin-stimulated glucose transport in 3T3-L1 adipocytes. Diabetes 2000 Oct 7
20 11096114 Human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase. A bifunctional protein requiring dimerization for transformylase activity but not for cyclohydrolase activity. J Biol Chem 2001 Mar 16 2
21 11323713 Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis. Nat Struct Biol 2001 May 3
22 11457277 Evaluation of the catalytic mechanism of AICAR transformylase by pH-dependent kinetics, mutagenesis, and quantum chemical calculations. J Am Chem Soc 2001 May 23 8
23 11487343 Linkage and redox isomerism in ruthenium complexes of catecholate, semi-quinone, and o-acylphenolate ligands derived from tri- and tetrahydroxy-9,10-anthracenediones. Inorg Chem 2001 Aug 13 1
24 11509501 Regulation of muscle GLUT-4 transcription by AMP-activated protein kinase. J Appl Physiol (1985) 2001 Sep 1
25 11554766 Cell cycle regulation via p53 phosphorylation by a 5'-AMP activated protein kinase activator, 5-aminoimidazole- 4-carboxamide-1-beta-D-ribofuranoside, in a human hepatocellular carcinoma cell line. Biochem Biophys Res Commun 2001 Sep 21 3
26 11948179 The kinetic mechanism of the human bifunctional enzyme ATIC (5-amino-4-imidazolecarboxamide ribonucleotide transformylase/inosine 5'-monophosphate cyclohydrolase). A surprising lack of substrate channeling. J Biol Chem 2002 Jun 21 1
27 12501179 Structural insights into the avian AICAR transformylase mechanism. Biochemistry 2002 Dec 31 9
28 12716734 5-amino-imidazole carboxamide riboside increases glucose transport and cell-surface GLUT4 content in skeletal muscle from subjects with type 2 diabetes. Diabetes 2003 May 7
29 12791703 Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells. J Biol Chem 2003 Aug 22 4
30 12974624 Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site. Biochemistry 2003 Sep 23 18
31 14756553 Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor. Biochemistry 2004 Feb 10 1
32 14756554 Catalytic mechanism of the cyclohydrolase activity of human aminoimidazole carboxamide ribonucleotide formyltransferase/inosine monophosphate cyclohydrolase. Biochemistry 2004 Feb 10 2
33 14966129 Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates. J Biol Chem 2004 Apr 23 8
34 15033479 AICAR stimulates adiponectin and inhibits cytokines in adipose tissue. Biochem Biophys Res Commun 2004 Apr 9 1
35 15114530 AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC. Am J Hum Genet 2004 Jun 5
36 15235328 Sending the signal: molecular mechanisms regulating glucose uptake. Med Sci Sports Exerc 2004 Jul 3
37 15265762 Role of the nitric oxide pathway in AMPK-mediated glucose uptake and GLUT4 translocation in heart muscle. Am J Physiol Endocrinol Metab 2004 Nov 8
38 15328001 Stimulators of AMP-activated protein kinase inhibit the respiratory burst in human neutrophils. FEBS Lett 2004 Aug 27 7
39 15358229 AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms. Biochem Biophys Res Commun 2004 Aug 13 2
40 15457444 Polyglutamation of methotrexate with common polymorphisms in reduced folate carrier, aminoimidazole carboxamide ribonucleotide transformylase, and thymidylate synthase are associated with methotrexate effects in rheumatoid arthritis. Arthritis Rheum 2004 Sep 2
41 15613684 Repression of protein synthesis and mTOR signaling in rat liver mediated by the AMPK activator aminoimidazole carboxamide ribonucleoside. Am J Physiol Endocrinol Metab 2005 May 1
42 15615517 Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors. J Med Chem 2004 Dec 30 3
43 15860681 AICAR and hyperosmotic stress increase insulin-stimulated glucose transport. J Appl Physiol (1985) 2005 Sep 3
44 15910743 AICAR suppresses IL-2 expression through inhibition of GSK-3 phosphorylation and NF-AT activation in Jurkat T cells. Biochem Biophys Res Commun 2005 Jul 1 8
45 16247961 Ring opening reactions: synthesis of AICAR analogs as potential antimetabolite agents. Nucleosides Nucleotides Nucleic Acids 2005 1
46 16377306 AMPK activation regulates apoptosis, adipogenesis, and lipolysis by eIF2alpha in adipocytes. Biochem Biophys Res Commun 2006 Feb 3 2
47 16395615 Metformin improves atypical protein kinase C activation by insulin and phosphatidylinositol-3,4,5-(PO4)3 in muscle of diabetic subjects. Diabetologia 2006 Feb 2
48 16798121 Diagnosing AICA-ribosiduria by capillary electrophoresis. J Chromatogr B Analyt Technol Biomed Life Sci 2006 Oct 20 1
49 16947783 Relationship between genetic variants in the adenosine pathway and outcome of methotrexate treatment in patients with recent-onset rheumatoid arthritis. Arthritis Rheum 2006 Sep 1
50 16949049 AMPK regulation of the growth of cultured human keratinocytes. Biochem Biophys Res Commun 2006 Oct 20 1