N-acetyltransferase 1 ; Homo sapiens






275 Article(s)
Download
PMID
Title
Journal
Pub. Date
#Total Relationship(s)
1 1423830 The role of the human acetylation polymorphism in the metabolic activation of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ). Carcinogenesis 1992 Oct 5
2 1441598 Polymorphisms of N-acetyltransferase genes. Xenobiotica 1992 Sep-Oct 2
3 1762071 Expression of monomorphic arylamine N-acetyltransferase (NAT1) in human leukocytes. J Pharmacol Exp Ther 1991 Dec 1
4 1996083 Monomorphic and polymorphic human arylamine N-acetyltransferases: a comparison of liver isozymes and expressed products of two cloned genes. Mol Pharmacol 1991 Feb 4
5 2340091 Human arylamine N-acetyltransferase genes: isolation, chromosomal localization, and functional expression. DNA Cell Biol 1990 Apr 1
6 2924904 Evidence for two closely related isozymes of arylamine N-acetyltransferase in human liver. FEBS Lett 1989 Feb 13 2
7 2980781 Mechanisms of aspartimide formation: the effects of protecting groups, acid, base, temperature and time. Pept Res 1988 Sep-Oct 1
8 7585580 Polymorphism in the N-acetyltransferase 1 (NAT1) polyadenylation signal: association of NAT1*10 allele with higher N-acetylation activity in bladder and colon tissue. Cancer Res 1995 Nov 15 5
9 7585581 Role of aromatic amine acetyltransferases, NAT1 and NAT2, in carcinogen-DNA adduct formation in the human urinary bladder. Cancer Res 1995 Nov 15 4
10 7598738 Purification of recombinant human N-acetyltransferase type 1 (NAT1) expressed in E. coli and characterization of its potential role in folate metabolism. Biochem Pharmacol 1995 Jun 16 10
11 7600914 Dapsone acetylation by human liver arylamine N-acetyltransferases and interaction with antiopportunistic infection drugs. Drug Metab Dispos 1995 Apr 1
12 7697826 Metabolic activation of heterocyclic aromatic amines catalyzed by human arylamine N-acetyltransferase isozymes (NAT1 and NAT2) expressed in Salmonella typhimurium. Carcinogenesis 1995 Mar 1
13 7717963 Acetylation of p-aminobenzoylglutamate, a folic acid catabolite, by recombinant human arylamine N-acetyltransferase and U937 cells. Biochem J 1995 Apr 1 7
14 7756106 Assessment of arylamine N-acetyltransferase (NAT1) activity in mononuclear leukocytes of cystic fibrosis patients. Br J Clin Pharmacol 1995 Jan 5
15 7889851 Polymorphism of human acetyltransferases. Environ Health Perspect 1994 Oct 2
16 7920698 Acetylator phenotyping: the urinary caffeine metabolite ratio in slow acetylators correlates with a marker of systemic NAT1 activity. Pharmacogenetics 1994 Jun 2
17 7929420 Structure-function studies of human arylamine N-acetyltransferases NAT1 and NAT2. Functional analysis of recombinant NAT1/NAT2 chimeras expressed in Escherichia coli. J Biol Chem 1994 Oct 28 2
18 8012961 Stable expression of human CYP1A2 and N-acetyltransferases in Chinese hamster CHL cells: mutagenic activation of 2-amino-3-methylimidazo[4,5-f]quinoline and 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline. Cancer Res 1994 Jul 1 1
19 8069857 Metabolic activation and carcinogen-DNA adduct detection in human larynx. Cancer Res 1994 Sep 15 4
20 8074447 Differential growth response to oestrogen of premalignant and malignant colonic cell lines. Anticancer Res 1994 May-Jun 1
21 8179482 Metabolic activation of aromatic and heterocyclic N-hydroxyarylamines by wild-type and mutant recombinant human NAT1 and NAT2 acetyltransferases. Arch Toxicol 1994 3
22 8182543 Human placental transfer and metabolism of p-aminobenzoic acid. J Pharmacol Exp Ther 1994 May 3
23 8220441 Individual variability in p-aminobenzoic acid N-acetylation by human N-acetyltransferase (NAT1) of peripheral blood. Pharmacogenetics 1993 Aug 1
24 8225481 32P-postlabelling studies on the DNA adducts of the food mutagens/carcinogens IQ and PhIP--adduct formation in a chemical system, and by rat and human metabolism. IARC Sci Publ 1993 2
25 8353847 Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases. Carcinogenesis 1993 Aug 14
26 8412184 Metabolic activation, DNA adducts, and H-ras mutations in human neoplastic and non-neoplastic laryngeal tissue. J Cell Biochem Suppl 1993 2
27 8466547 Role of polymorphic and monomorphic human arylamine N-acetyltransferases in determining sulfamethoxazole metabolism. Biochem Pharmacol 1993 Mar 24 6
28 8565119 The role of acetylation in the mutagenicity of the antitumor agent, batracylin. Carcinogenesis 1996 Jan 1
29 8597119 Genetic susceptibility and carcinogen-DNA adduct formation in human urinary bladder carcinogenesis. Toxicol Lett 1995 Dec 2
30 8665493 N-acetyltransferase expression and metabolic activation of the food-derived heterocyclic amines in the human mammary gland. Cancer Res 1996 Jun 15 2
31 8752161 Human N-acetylation of benzidine: role of NAT1 and NAT2. Cancer Res 1996 Sep 1 23
32 8773572 Immunochemical detection of arylamine N-acetyltransferase in normal and neoplastic bladder. J Histochem Cytochem 1996 Sep 1
33 8870952 Drug metabolizing enzyme activities in porcine urinary bladder epithelial cell cultures (PUBEC). Arch Toxicol 1996 1
34 8895986 Cytochrome P-450 and acetyltransferase expression as biomarkers of carcinogen-DNA adduct levels and human cancer susceptibility. Prog Clin Biol Res 1996 1
35 8960058 A fragment consisting of the first 204 amino-terminal amino acids of human arylamine N-acetyltransferase one (NAT1) and the first transacetylation step of catalysis. Biochem Pharmacol 1997 Jan 10 2
36 9131488 N-acetyltransferases: pharmacogenetics and clinical consequences of polymorphic drug metabolism. J Pharmacokinet Biopharm 1996 Oct 3
37 9163700 Metabolic activation of aromatic amines by human pancreas. Carcinogenesis 1997 May 2
38 9168895 Identification of a novel allele at the human NAT1 acetyltransferase locus. Biochem Biophys Res Commun 1997 Apr 28 3
39 9173883 Study of the role of the highly conserved residues Arg9 and Arg64 in the catalytic function of human N-acetyltransferases NAT1 and NAT2 by site-directed mutagenesis. Biochem J 1997 Apr 1 4
40 9202739 Human acetyltransferase polymorphisms. Mutat Res 1997 May 12 3
41 9202744 Rodent models of the human acetylation polymorphism: comparisons of recombinant acetyltransferases. Mutat Res 1997 May 12 1
42 9202751 The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies. Mutat Res 1997 May 12 2
43 9288889 Immunochemical, 32P-postlabeling, and GC/MS detection of 4-aminobiphenyl-DNA adducts in human peripheral lung in relation to metabolic activation pathways involving pulmonary N-oxidation, conjugation, and peroxidation. Mutat Res 1997 Aug 1 1
44 9321764 A simplified assay for the arylamine N-acetyltransferase 2 polymorphism validated by phenotyping with isoniazid. J Med Genet 1997 Sep 1
45 9342682 Determination of p-aminosalicylic acid and its N-acetylated metabolite in human urine by capillary zone electrophoresis as a measure of in vivo N-acetyltransferase 1 activity. J Chromatogr B Biomed Sci Appl 1997 Sep 12 1
46 9459121 Epidermal N-acetylation of p-aminobenzoyl glutamic acid: difference in response to ultraviolet B irradiation. J Dermatol Sci 1998 Jan 3
47 9484803 Genotyping human arylamine N-acetyltransferase type 1 (NAT1): the identification of two novel allelic variants. Biochem Pharmacol 1998 Feb 1 1
48 9511182 Identification and characterization of variant alleles of human acetyltransferase NAT1 with defective function using p-aminosalicylate as an in-vivo and in-vitro probe. Pharmacogenetics 1998 Feb 7
49 9511183 Functional polymorphism of the human arylamine N-acetyltransferase type 1 gene caused by C190T and G560A mutations. Pharmacogenetics 1998 Feb 4
50 9571233 Substrate selectivity of mouse N-acetyltransferases 1, 2, and 3 expressed in COS-1 cells. Drug Metab Dispos 1998 May 1