melanocortin 1 receptor ; Homo sapiens






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1 2177734 Synthesis of alpha-MSH fragments containing phenylalanine mustard for receptor studies. Int J Pept Protein Res 1990 Sep 1
2 2540997 Phorbol ester impairs melanotropin receptor function and stimulates growth of cultured M2R melanoma cells. Eur J Pharmacol 1989 Mar 7 5
3 3665846 Inhibition by melittin and fluphenazine of melanotropin receptor function and adenylate cyclase in M2R melanoma cell membranes. Endocrinology 1987 Nov 1
4 7581459 Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans. Nat Genet 1995 Nov 3
5 7980588 Binding and cAMP studies of melanotropin peptides with the cloned human peripheral melanocortin receptor, hMC1R. Biochem Biophys Res Commun 1994 Nov 15 1
6 8392369 Synthetic peptides corresponding to the calmodulin-binding domains of skeletal muscle myosin light chain kinase and human erythrocyte Ca2+ pump interact with and permeabilize liposomes and cell membranes. Biochemistry 1993 Jul 6 1
7 8605020 Identification of ligand binding residues in extracellular loops of the melanocortin 1 receptor. Biochem Biophys Res Commun 1996 Feb 15 2
8 8801544 Characterization of a putative alpha-MSH antagonist 153N-6 at melanocortin receptor subtypes by radioligand binding. Peptides 1996 2
9 9171884 Biological and conformational examination of stereochemical modifications using the template melanotropin peptide, Ac-Nle-c[Asp-His-Phe-Arg-Trp-Ala-Lys]-NH2, on human melanocortin receptors. J Med Chem 1997 May 23 6
10 9216831 Discovery of prototype peptidomimetic agonists at the human melanocortin receptors MC1R and MC4R. J Med Chem 1997 Jul 4 1
11 9487023 Melanocortin receptors, red hair, and skin cancer. J Investig Dermatol Symp Proc 1997 Aug 2
12 9571181 Human pigmentation phenotype: a point mutation generates nonfunctional MSH receptor. Biochem Biophys Res Commun 1998 Apr 17 1
13 9799269 Melanocortin receptor 1 (MC1R) mutations and coat color in pigs. Genetics 1998 Nov 4
14 9861445 Amino acid residues in third intracellular loop of melanocortin 1 receptor are involved in G-protein coupling. Biochem Mol Biol Int 1998 Dec 1
15 10101176 High polymorphism at the human melanocortin 1 receptor locus. Genetics 1999 Apr 2
16 10465111 Mutational analysis of the N-ras, p53, p16INK4a, CDK4, and MC1R genes in human congenital melanocytic naevi. J Med Genet 1999 Aug 2
17 10537004 Participation of the melanocortin-1 receptor in the UV control of pigmentation. J Investig Dermatol Symp Proc 1999 Sep 1
18 10733465 Evidence for variable selective pressures at MC1R. Am J Hum Genet 2000 Apr 1
19 10816645 The melanocortin-1 receptor and human pigmentation. Ann N Y Acad Sci 1999 Oct 20 3
20 10885670 The melanocortin 1 receptor (MC1R): more than just red hair. Pigment Cell Res 2000 Jun 2
21 11041357 Biochemical and genetic studies of pigment-type switching. Pigment Cell Res 2000 2
22 11080697 Development of a facile method for high throughput screening with reporter gene assays. J Biomol Screen 2000 Oct 1
23 11237737 Cysteine residues are involved in structure and function of melanocortin 1 receptor: Substitution of a cysteine residue in transmembrane segment two converts an agonist to antagonist. Biochem Biophys Res Commun 2001 Mar 9 8
24 11305330 Melanocortin-1 receptor gene variants in four Chinese ethnic populations. Cell Res 2001 Mar 1
25 11564554 Minimization of MC1R selectivity by modification of the core structure of alpha-MSH-ND. Chem Biol 2001 Sep 5
26 11602344 Human pigmentation genes: identification, structure and consequences of polymorphic variation. Gene 2001 Oct 17 2
27 11708951 The melanocortin-1 receptor: red hair and beyond. Arch Dermatol 2001 Nov 3
28 11720436 Prostate cancer risk: associations with ultraviolet radiation, tyrosinase and melanocortin-1 receptor genotypes. Br J Cancer 2001 Nov 16 1
29 11830546 Alpha-melanocyte stimulating hormone potentiates p16/CDKN2A expression in human skin after ultraviolet irradiation. Cancer Res 2002 Feb 1 1
30 11833005 A polymorphism in the agouti signaling protein gene is associated with human pigmentation. Am J Hum Genet 2002 Mar 4
31 11837451 Agouti: from mouse to man, from skin to fat. Pigment Cell Res 2002 Feb 3
32 11912210 Molecular determinants of human melanocortin-4 receptor responsible for antagonist SHU9119 selective activity. J Biol Chem 2002 Jun 7 1
33 12006619 Human melanocortin 1 receptor variants, receptor function and melanocyte response to UV radiation. J Cell Sci 2002 Jun 1 2
34 12161144 Structure-activity relationship of linear peptide Bu-His-DPhe-Arg-Trp-Gly-NH(2) at the human melanocortin-1 and -4 receptors: arginine substitution. Bioorg Med Chem Lett 2002 Sep 2 2
35 12453185 Regulation of the human melanocortin 1 receptor expression in epidermal melanocytes by paracrine and endocrine factors and by ultraviolet radiation. Pigment Cell Res 2002 Dec 2
36 12467633 Structure-activity relationship of linear peptide Bu-His-DPhe-Arg-Trp-Gly-NH(2) at the human melanocortin-1 and -4 receptors: histidine substitution. Bioorg Med Chem Lett 2003 Jan 6 9
37 12473109 Loss-of-function variants of the human melanocortin-1 receptor gene in melanoma cells define structural determinants of receptor function. Eur J Biochem 2002 Dec 1
38 12519127 Agouti signal protein regulation in human melanoma cells. Pigment Cell Res 2003 Feb 2
39 12600969 Rapid genotyping of melanocortin-1 receptor with use of fluorescence-labeled oligonucleotides. Clin Chem 2003 Mar 1
40 12646021 Discovery of tyrosine-based potent and selective melanocortin-1 receptor small-molecule agonists with anti-inflammatory properties. J Med Chem 2003 Mar 27 1
41 12657270 Structure-activity relationship of cyclic peptide penta-c[Asp-His(6)-DPhe(7)-Arg(8)-Trp(9)-Lys]-NH(2) at the human melanocortin-1 and -4 receptors: His(6) substitution. Bioorg Med Chem Lett 2003 Apr 7 2
42 12663858 The melanocortin-1 receptor gene mediates female-specific mechanisms of analgesia in mice and humans. Proc Natl Acad Sci U S A 2003 Apr 15 2
43 12687585 Evolution of a pigmentation gene, the melanocortin-1 receptor, in primates. Am J Phys Anthropol 2003 May 4
44 12818667 Novel tetrahydropyran-based peptidomimetics from a bioisosteric transformation of a tripeptide. Evidence of their activity at melanocortin receptors. Bioorg Med Chem 2003 Jul 17 1
45 12851328 Accessory proteins for melanocortin signaling: attractin and mahogunin. Ann N Y Acad Sci 2003 Jun 4
46 12851338 P-locus is a target for the melanogenic effects of MC-1R signaling: a possible control point for facultative pigmentation. Ann N Y Acad Sci 2003 Jun 2
47 12873485 Sub-nanomolar hMC1R agonists by end-capping of the melanocortin tetrapeptide His-D-Phe-Arg-Trp-NH(2). Bioorg Med Chem Lett 2003 Aug 18 7
48 12885967 Unmelanized plumage patterns in Old World leaf warblers do not correspond to sequence variation at the melanocortin-1 receptor locus (MC1R). Mol Biol Evol 2003 Oct 2
49 12950734 Rate limiting factors in melanocortin 1 receptor signalling through the cAMP pathway. Pigment Cell Res 2003 Oct 4
50 14500544 Regulation of melanocortin 1 receptor expression at the mRNA and protein levels by its natural agonist and antagonist. FASEB J 2003 Nov 1