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13 | 7720520 | Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes. | Drug Metab Dispos | 1995 Jan |
3 |
14 | 7736913 | Biotransformation of losartan to its active carboxylic acid metabolite in human liver microsomes. Role of cytochrome P4502C and 3A subfamily members. | Drug Metab Dispos | 1995 Feb |
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15 | 7741772 | Hydroxylation of the antimalarial drug 58C80 by CYP2C9 in human liver microsomes: comparison with mephenytoin and tolbutamide hydroxylations. | Biochem Pharmacol | 1995 Mar 30 |
2 |
16 | 7763308 | Role of cytochrome P450 2C9 and an allelic variant in the 4'-hydroxylation of (R)- and (S)-flurbiprofen. | Biochem Pharmacol | 1995 May 11 |
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17 | 7773301 | Detection of CYP2C9 polymorphism based on the polymerase chain reaction in Chinese. | Pharmacogenetics | 1995 Feb |
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18 | 7794915 | Transcriptional regulation of human CYP2C genes: functional comparison of CYP2C9 and CYP2C18 promoter regions. | Biochemistry | 1995 Jun 27 |
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19 | 7891318 | Human hepatic cytochrome P450 2C9 catalyzes the rate-limiting pathway of torsemide metabolism. | J Pharmacol Exp Ther | 1995 Mar |
9 |
20 | 7903909 | Taxol metabolism by human liver microsomes: identification of cytochrome P450 isozymes involved in its biotransformation. | Cancer Res | 1994 Jan 15 |
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21 | 7981013 | Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms. | Br J Clin Pharmacol | 1994 Aug |
2 |
22 | 8004131 | Impaired (S)-warfarin metabolism catalysed by the R144C allelic variant of CYP2C9. | Pharmacogenetics | 1994 Feb |
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23 | 8070855 | Characterization of the human cytochrome P450 isozymes responsible for styrene metabolism. | IARC Sci Publ | 1993 |
1 |
24 | 8148870 | Cytochrome P450 mediated metabolism of diazepam in human and rat: involvement of human CYP2C in N-demethylation in the substrate concentration-dependent manner. | Pharmacogenetics | 1993 Dec |
3 |
25 | 8203907 | Evaluation of triacetyloleandomycin, alpha-naphthoflavone and diethyldithiocarbamate as selective chemical probes for inhibition of human cytochromes P450. | Arch Biochem Biophys | 1994 Jun |
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26 | 8216369 | Cytochrome P450 2C9 is responsible for hydroxylation of the naphthoquinone antimalarial drug 58C80 in human liver. | Biochem Pharmacol | 1993 Oct 5 |
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27 | 8286335 | Thiophene derivatives as new mechanism-based inhibitors of cytochromes P-450: inactivation of yeast-expressed human liver cytochrome P-450 2C9 by tienilic acid. | Biochemistry | 1994 Jan 11 |
2 |
28 | 8333835 | Gene structure and upstream regulatory regions of human CYP2C9 and CYP2C18. | Biochem Biophys Res Commun | 1993 Jul 15 |
3 |
29 | 8375128 | Disposition of drugs in cystic fibrosis. V. In vivo CYP2C9 activity as probed by (S)-warfarin is not enhanced in cystic fibrosis. | Clin Pharmacol Ther | 1993 Sep |
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30 | 8417277 | Cytochrome P450TB (CYP2C): a major monooxygenase catalyzing diclofenac 4'-hydroxylation in human liver. | Life Sci | 1993 |
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31 | 8454228 | [Genetic polymorphism in human drug metabolism]. | Nihon Yakurigaku Zasshi | 1993 Feb |
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32 | 8518837 | Hepatic microsomal tolbutamide hydroxylation in Japanese: in vitro evidence for rapid and slow metabolizers. | Pharmacogenetics | 1993 Apr |
3 |
33 | 8535411 | Involvement of CYP2C in the metabolism of cannabinoids by human hepatic microsomes from an old woman. | Biol Pharm Bull | 1995 Aug |
1 |
34 | 8542584 | Development of human cytochrome P450-expressing cell lines: application in mutagenicity testing of ochratoxin A. | Cancer Res | 1996 Jan 15 |
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35 | 8587855 | Antidepressant drug interactions and the cytochrome P450 system: a critical appraisal. | Pharmacotherapy | 1995 Nov-Dec |
4 |
36 | 8613951 | Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes. | J Pharmacol Exp Ther | 1996 Apr |
2 |
37 | 8627562 | Identification of the human P450 enzymes involved in lansoprazole metabolism. | J Pharmacol Exp Ther | 1996 May |
1 |
38 | 8654202 | Identification of human cytochrome P450 isozymes responsible for the in vitro oxidative metabolism of finasteride. | Drug Metab Dispos | 1995 Oct |
2 |
39 | 8654205 | Identification of the human and rat P450 enzymes responsible for the sulfoxidation of S-methyl N,N-diethylthiolcarbamate (DETC-ME). The terminal step in the bioactivation of disulfiram. | Drug Metab Dispos | 1995 Oct |
1 |
40 | 8654206 | Identification of the human liver cytochrome P450 enzymes involved in the metabolism of zileuton (ABT-077) and its N-dehydroxylated metabolite, Abbott-66193. | Drug Metab Dispos | 1995 Oct |
3 |
41 | 8681455 | The metabolism of tamoxifen by human cytochromes P450 is rationalized by molecular modelling of the enzyme-substrate interactions: potential importance to its proposed anti-carcinogenic/carcinogenic actions. | Carcinogenesis | 1996 Jun |
1 |
42 | 8681486 | Antipyrine as a probe for human oxidative drug metabolism: identification of the cytochrome P450 enzymes catalyzing 4-hydroxyantipyrine, 3-hydroxymethylantipyrine, and norantipyrine formation. | Clin Pharmacol Ther | 1996 Jun |
4 |
43 | 8687505 | Cytochrome P-450 expression in sudden infant death syndrome. | Biochem Pharmacol | 1996 Aug 9 |
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44 | 8698676 | Serotonin selective reuptake inhibitor drug interactions and the cytochrome P450 system. | J Clin Psychiatry | 1996 |
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45 | 8700140 | Tienilic acid-induced autoimmune hepatitis: anti-liver and-kidney microsomal type 2 autoantibodies recognize a three-site conformational epitope on cytochrome P4502C9. | Mol Pharmacol | 1996 Aug |
2 |
46 | 8703658 | N-Hydroxylation of dapsone by multiple enzymes of cytochrome P450: implications for inhibition of haemotoxicity. | Br J Clin Pharmacol | 1995 Dec |
1 |
47 | 8737761 | In vitro comparative inhibition profiles of major human drug metabolising cytochrome P450 isozymes (CYP2C9, CYP2D6 and CYP3A4) by HMG-CoA reductase inhibitors. | Eur J Clin Pharmacol | 1996 |
5 |
48 | 8742240 | Putative active site template model for cytochrome P4502C9 (tolbutamide hydroxylase). | Drug Metab Dispos | 1996 Feb |
3 |
49 | 8747411 | Genetic polymorphism of CYP2C9 and its effect on warfarin maintenance dose requirement in patients undergoing anticoagulation therapy. | Pharmacogenetics | 1995 Dec |
1 |
50 | 8750925 | Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans. | Naunyn Schmiedebergs Arch Pharmacol | 1995 Dec |
2 |