furin, paired basic amino acid cleaving enzyme ; Homo sapiens






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1 1325651 Regulation of PACE propeptide-processing activity: requirement for a post-endoplasmic reticulum compartment and autoproteolytic activation. Proc Natl Acad Sci U S A 1992 Sep 1 6
2 1360148 Inhibition of furin-mediated cleavage activation of HIV-1 glycoprotein gp160. Nature 1992 Nov 26 5
3 1512259 Cloning and functional expression of Dfurin2, a subtilisin-like proprotein processing enzyme of Drosophila melanogaster with multiple repeats of a cysteine motif. J Biol Chem 1992 Aug 25 4
4 1571548 Preferred sequence requirements for cleavage of pro-von Willebrand factor by propeptide-processing enzymes. Blood 1992 May 1 6
5 1587790 Molecular and enzymatic properties of furin, a Kex2-like endoprotease involved in precursor cleavage at Arg-X-Lys/Arg-Arg sites. J Biochem 1992 Mar 14
6 1628614 Influenza virus hemagglutinin with multibasic cleavage site is activated by furin, a subtilisin-like endoprotease. EMBO J 1992 Jul 1
7 1629222 Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage. J Biol Chem 1992 Jul 15 20
8 1644796 Purification and characterization of furin, a Kex2-like processing endoprotease, produced in Chinese hamster ovary cells. J Biol Chem 1992 Aug 15 4
9 1644824 Human furin is a calcium-dependent serine endoprotease that recognizes the sequence Arg-X-X-Arg and efficiently cleaves anthrax toxin protective antigen. J Biol Chem 1992 Aug 15 22
10 1680673 Identification of a somatostatin-14-generating propeptide converting enzyme as a member of the kex2/furin/PC family. Endocrinology 1991 Oct 1
11 1843280 Furin: the prototype mammalian subtilisin-like proprotein-processing enzyme. Endoproteolytic cleavage at paired basic residues of proproteins of the eukaryotic secretory pathway. Enzyme 1991 2
12 1905715 Arg-X-Lys/Arg-Arg motif as a signal for precursor cleavage catalyzed by furin within the constitutive secretory pathway. J Biol Chem 1991 Jul 5 4
13 1915835 cDNA sequence of a Drosophila melanogaster gene, Dfur1, encoding a protein structurally related to the subtilisin-like proprotein processing enzyme furin. FEBS Lett 1991 Sep 9 1
14 1930163 Sequence requirements for proteolytic cleavage of precursors with paired basic amino acids. Biochem Biophys Res Commun 1991 Sep 30 3
15 2017186 Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared to PC2. Mol Endocrinol 1991 Jan 1
16 2094803 Furin is a subtilisin-like proprotein processing enzyme in higher eukaryotes. Mol Biol Rep 1990 Nov 1
17 2169760 cDNA sequence of two distinct pituitary proteins homologous to Kex2 and furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases. DNA Cell Biol 1990 Jul-Aug 2
18 2251280 Expression of a human proprotein processing enzyme: correct cleavage of the von Willebrand factor precursor at a paired basic amino acid site. Proc Natl Acad Sci U S A 1990 Dec 9
19 2266110 Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells. J Biol Chem 1990 Dec 25 1
20 2548282 Cisplatin for small-cell lung cancer. Semin Oncol 1989 Aug 2
21 3023061 Evolutionary conserved close linkage of the c-fes/fps proto-oncogene and genetic sequences encoding a receptor-like protein. EMBO J 1986 Sep 2
22 7474409 Intensive chemotherapy with cisplatin, doxorubicin, cyclophosphamide, etoposide and granulocyte colony-stimulating factor for advanced thymoma or thymic cancer: preliminary results. Jpn J Clin Oncol 1995 Oct 1
23 7499343 Localization of furin to the trans-Golgi network and recycling from the cell surface involves Ser and Tyr residues within the cytoplasmic domain. J Biol Chem 1995 Nov 24 7
24 7508380 Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface. EMBO J 1994 Jan 1 6
25 7510003 Presence of furin mRNA in cultured bovine endothelial cells and possible involvement of furin in the processing of the endothelin precursor. J Cardiovasc Pharmacol 1993 6
26 7577915 Designing subtilisin BPN' to cleave substrates containing dibasic residues. Biochemistry 1995 Oct 17 1
27 7592877 A second mutant allele of furin in the processing-incompetent cell line, LoVo. Evidence for involvement of the homo B domain in autocatalytic activation. J Biol Chem 1995 Nov 3 13
28 7619075 Direct role of furin in mammalian prosomatostatin processing. Biochem J 1995 Jul 1 8
29 7642593 Fluorescent peptidyl substrates as an aid in studying the substrate specificity of human prohormone convertase PC1 and human furin and designing a potent irreversible inhibitor. J Biol Chem 1995 Aug 18 9
30 7690548 A mutation of furin causes the lack of precursor-processing activity in human colon carcinoma LoVo cells. Biochem Biophys Res Commun 1993 Sep 15 5
31 7710100 Internally quenched fluorogenic substrate for furin. Anal Biochem 1995 Jan 1 4
32 7721880 Proparathyroid hormone is preferentially cleaved to parathyroid hormone by the prohormone convertase furin. A mass spectrometric study. J Biol Chem 1995 Apr 21 2
33 7729512 Processing of proendothelin-1 by human furin convertase. FEBS Lett 1995 Apr 10 1
34 7738018 Furin-induced cleavage and activation of Shiga toxin. J Biol Chem 1995 May 5 2
35 7741698 An internally quenched fluorogenic substrate of prohormone convertase 1 and furin leads to a potent prohormone convertase inhibitor. Biochem J 1995 May 1 7
36 7746327 Furin-dependent intracellular activation of the human stromelysin-3 zymogen. Nature 1995 May 18 1
37 7805839 Vitellogenin gene of the silkworm, Bombyx mori: structure and sex-dependent expression. FEBS Lett 1994 Dec 19 3
38 7819325 Furin-mediated proprotein processing activity: involvement of negatively charged amino acid residues in the substrate binding region. Biochimie 1994 1
39 7819326 Processing of viral glycoproteins by the subtilisin-like endoprotease furin and its inhibition by specific peptidylchloroalkylketones. Biochimie 1994 1
40 7822102 Design and synthesis of novel inhibitors of prohormone convertases. Int J Pept Protein Res 1994 Sep 4
41 7852339 Endoproteolytic cleavage of its propeptide is a prerequisite for efficient transport of furin out of the endoplasmic reticulum. J Biol Chem 1995 Feb 10 11
42 8013667 Cleavage of proalbumin peptides by furin reveals unexpected restrictions at the P2 and P'1 sites. FEBS Lett 1994 Jun 20 1
43 8027078 Cleavage of pseudomonas exotoxin and diphtheria toxin by a furin-like enzyme prepared from beef liver. J Biol Chem 1994 Jul 8 1
44 8030261 Activation of an influenza virus A/turkey/Oregon/71 HA insertion variant by the subtilisin-like endoprotease furin. Virology 1994 Aug 1 1
45 8139055 Proteolytic cleavage of wild type and mutants of the F protein of human parainfluenza virus type 3 by two subtilisin-like endoproteases, furin and Kex2. J Virol 1994 Apr 1
46 8189547 A furin-defective cell line is able to process correctly the gp160 of human immunodeficiency virus type 1. J Virol 1994 Jun 5
47 8194522 Retrieval of TGN proteins from the cell surface requires endosomal acidification. EMBO J 1994 May 15 1
48 8218226 PACE4 is a member of the mammalian propeptidase family that has overlapping but not identical substrate specificity to PACE. Biochemistry 1993 Nov 2 6
49 8226855 Cloning and functional expression of a cDNA encoding the catalytic subunit of bovine enterokinase. J Biol Chem 1993 Nov 5 5
50 8226974 Defective processing of the insulin receptor in an endoprotease-deficient Chinese hamster cell strain is corrected by expression of mouse furin. J Biol Chem 1993 Nov 15 1