thiopurine S-methyltransferase ; Homo sapiens






772 Article(s)
Download
PMID
Title
Journal
Pub. Date
#Total Relationship(s)
1 657528 Human erythrocyte thiopurine methyltransferase: radiochemical microassay and biochemical properties. Clin Chim Acta 1978 May 2 2
2 1306116 Human liver thiopurine methyltransferase pharmacogenetics: biochemical properties, liver-erythrocyte correlation and presence of isozymes. Pharmacogenetics 1992 Aug 8
3 1441597 Methylation pharmacogenetics: thiopurine methyltransferase as a model system. Xenobiotica 1992 Sep-Oct 3
4 1510725 Human kidney thiopurine methyltransferase. Photoaffinity labeling with S-adenosyl-L-methionine. Biochem Pharmacol 1992 Aug 18 29
5 1585469 The importance of thiopurine methyltransferase activity for the use of azathioprine in transplant recipients. Transplantation 1992 May 10
6 1732075 Interethnic difference in thiopurine methyltransferase activity. Clin Pharmacol Ther 1992 Jan 3
7 1973780 Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia. Lancet 1990 Jul 28 4
8 1981712 Thiopurine methyltransferase isozymes in human renal tissue. Drug Metab Dispos 1990 Sep-Oct 8
9 2758725 Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism. Clin Pharmacol Ther 1989 Aug 4
10 2865352 Cephalosporin-induced hypoprothrombinemia: possible role for thiol methylation of 1-methyltetrazole-5-thiol and 2-methyl-1,3,4-thiadiazole-5-thiol. J Pharmacol Exp Ther 1985 Nov 8
11 3467886 Thiopurine pharmacogenetics in leukemia: correlation of erythrocyte thiopurine methyltransferase activity and 6-thioguanine nucleotide concentrations. Clin Pharmacol Ther 1987 Jan 10
12 3612526 Human lymphocyte thiopurine methyltransferase pharmacogenetics: effect of phenotype on 6-mercaptopurine-induced inhibition of mitogen stimulation. J Pharmacol Exp Ther 1987 Jul 9
13 3950915 Thiopurine methyltransferase: structure-activity relationships for benzoic acid inhibitors and thiophenol substrates. J Med Chem 1986 Mar 7
14 4062957 Thiopurine methyltransferase: mouse kidney and liver assay conditions, biochemical properties and strain variation. Biochem Pharmacol 1985 Nov 1 1
15 6633508 Thiopurine methyltransferase. Aromatic thiol substrates and inhibition by benzoic acid derivatives. Mol Pharmacol 1983 Nov 13
16 6714437 Human pharmacogenetics of methyl conjugation. Fed Proc 1984 May 15 2
17 6838629 Human kidney thiopurine methyltransferase. Purification and biochemical properties. Biochem Pharmacol 1983 Mar 1 10
18 7191632 Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet 1980 Sep 5
19 7408396 Thiol S-methylation in uremia: erythrocyte enzyme activities and plasma inhibitors. Clin Pharmacol Ther 1980 Sep 4
20 7570968 Monitoring of azathioprine-induced immunosuppression with thiopurine methyltransferase activity in kidney transplant recipients. Transplantation 1995 Oct 15 6
21 7603453 Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferase. Mol Pharmacol 1995 Jun 23
22 7621855 Commentary on interactions between 6-mercaptopurine therapy and thiopurine-methyl-transferase (TPMT) activity. Eur J Clin Pharmacol 1995 2
23 7628307 Thiopurine methyltransferase pharmacogenetics. Cloning of human liver cDNA and a processed pseudogene on human chromosome 18q21.1. Drug Metab Dispos 1995 Mar 4
24 7640156 Sulphasalazine inhibition of thiopurine methyltransferase: possible mechanism for interaction with 6-mercaptopurine and azathioprine. Br J Clin Pharmacol 1995 Apr 14
25 7703493 Polymorphic thiopurine methyltransferase in erythrocytes is indicative of activity in leukemic blasts from children with acute lymphoblastic leukemia. Blood 1995 Apr 1 3
26 7713396 Segregation analysis of human red blood cell thiopurine methyltransferase activity. Genet Epidemiol 1995 6
27 7802704 Purine substrates for human thiopurine methyltransferase. Biochem Pharmacol 1994 Nov 29 15
28 7818564 Azathioprine-related bone marrow toxicity and low activities of purine enzymes in patients with rheumatoid arthritis. Arthritis Rheum 1995 Jan 6
29 7857117 The role of genetic variation in thiopurine methyltransferase activity and the efficacy and/or side effects of azathioprine therapy in dermatologic patients. Arch Dermatol 1995 Feb 6
30 7862671 A single point mutation leading to loss of catalytic activity in human thiopurine S-methyltransferase. Proc Natl Acad Sci U S A 1995 Feb 14 2
31 7866549 High-performance liquid chromatographic assay of human red blood cell thiopurine methyltransferase activity. J Chromatogr B Biomed Appl 1994 Nov 4 7
32 7946931 Thiopurine methyltransferase activity in a French population: h.p.l.c. assay conditions and effects of drugs and inhibitors. Br J Clin Pharmacol 1994 Jul 10
33 7957529 Interactions between 6-mercaptopurine therapy and thiopurine-methyl-transferase (TPMT) activity. Eur J Clin Pharmacol 1994 2
34 8257179 Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia. Arch Dis Child 1993 Nov 1
35 8272762 Gender difference in red blood cell thiopurine methyltransferase activity. Scand J Clin Lab Invest 1993 Nov 2
36 8299312 Thiopurine methyltransferase activity in American white subjects and black subjects. Clin Pharmacol Ther 1994 Jan 7
37 8316220 Human thiopurine methyltransferase: molecular cloning and expression of T84 colon carcinoma cell cDNA. Mol Pharmacol 1993 Jun 8
38 8318412 Is 6-thioguanine more appropriate than 6-mercaptopurine for children with acute lymphoblastic leukaemia? Br J Cancer 1993 Jul 6
39 8330462 Thiopurine S-methyltransferase activity in a Chinese population. Clin Pharmacol Ther 1993 Jul 1
40 8392551 Diethyldithiocarbamate S-methylation: evidence for catalysis by human liver thiol methyltransferase and thiopurine methyltransferase. J Pharmacol Exp Ther 1993 Jul 6
41 8453854 Thiopurine methyltransferase activity in a sample population of black subjects in Florida. Clin Pharmacol Ther 1993 Mar 2
42 8453958 Identification of factors regulating thiopurine methyltransferase activity in a Norwegian population. Eur J Clin Pharmacol 1993 3
43 8561894 Thiopurine methyltransferase pharmacogenetics: human gene cloning and characterization of a common polymorphism. DNA Cell Biol 1996 Jan 2
44 8563768 Higher activity of polymorphic thiopurine S-methyltransferase in erythrocytes from neonates compared to adults. Pharmacogenetics 1995 Oct 9
45 8582469 Erythrocyte fraction affects red blood cell thiopurine methyltransferase activity. Eur J Clin Pharmacol 1995 4
46 8644731 Thiopurine S-methyltransferase deficiency: two nucleotide transitions define the most prevalent mutant allele associated with loss of catalytic activity in Caucasians. Am J Hum Genet 1996 Apr 6
47 8687298 Monitoring of TPMT in heart transplant recipients under immunosuppressive therapy with azathioprine. Artif Organs 1995 Sep 4
48 8689814 Thiopurine methyltransferase activity in a Korean population sample of children. Clin Pharmacol Ther 1996 Jul 4
49 8738760 Should 6-thioguanine nucleotides be monitored in heart transplant recipients given azathioprine? Ther Drug Monit 1996 Jun 2
50 8857546 Individualizing therapy with 6-mercaptopurine and 6-thioguanine related to the thiopurine methyltransferase genetic polymorphism. Ther Drug Monit 1996 Aug 4