protein-L-isoaspartate (D-aspartate) O-methyltransferase ; Homo sapiens






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1 2777770 The primary structure of a protein carboxyl methyltransferase from bovine brain that selectively methylates L-isoaspartyl sites. J Biol Chem 1989 Sep 25 1
2 7492588 Hampered expression of isoaspartyl protein carboxyl methyltransferase gene in the human cataractous lens. Biochim Biophys Acta 1995 Oct 19 4
3 7663167 Cloning, expression, and purification of rat brain protein L-isoaspartyl methyltransferase. Protein Expr Purif 1995 Jun 4
4 10496068 Polymorphic forms of the protein L-isoaspartate (D-aspartate) O-methyltransferase involved in the repair of age-damaged proteins. J Hum Genet 1999 2
5 10660456 Development of improved high-performance liquid chromatography conditions for nonisotopic detection of isoaspartic acid to determine the extent of protein deamidation. Anal Biochem 2000 Feb 15 1
6 11080641 Crystal structure of protein isoaspartyl methyltransferase: a catalyst for protein repair. Structure 2000 Nov 15 2
7 11152138 The amino terminus of PKA catalytic subunit--a site for introduction of posttranslational heterogeneities by deamidation: D-Asp2 and D-isoAsp2 containing isozymes. Protein Sci 2000 Nov 6
8 11847284 Crystal structure of human L-isoaspartyl-O-methyl-transferase with S-adenosyl homocysteine at 1.6-A resolution and modeling of an isoaspartyl-containing peptide at the active site. Protein Sci 2002 Mar 4
9 12023972 Altered levels of S-adenosylmethionine and S-adenosylhomocysteine in the brains of L-isoaspartyl (D-Aspartyl) O-methyltransferase-deficient mice. J Biol Chem 2002 Aug 2 4
10 12390520 Down-regulation of protein L-isoaspartyl methyltransferase in human epileptic hippocampus contributes to generation of damaged tubulin. J Neurochem 2002 Nov 2
11 12603326 Deamidation of labile asparagine residues in the autoregulatory sequence of human phenylalanine hydroxylase. Eur J Biochem 2003 Mar 2
12 16256389 A known functional polymorphism (Ile120Val) of the human PCMT1 gene and risk of spina bifida. Mol Genet Metab 2006 Jan 1
13 17892495 Accumulation of altered aspartyl residues in erythrocyte proteins from patients with Down's syndrome. FEBS J 2007 Oct 2
14 18381200 Suppression of protein l-isoaspartyl (d-aspartyl) methyltransferase results in hyperactivation of EGF-stimulated MEK-ERK signaling in cultured mammalian cells. Biochem Biophys Res Commun 2008 Jun 20 6
15 18407833 Reactive oxygen species generated by thiol-modifying phenylarsine oxide stimulate the expression of protein L-isoaspartyl methyltransferase. Biochem Biophys Res Commun 2008 Jun 27 14
16 18582478 Up-regulation of protein L-isoaspartyl methyltransferase expression by lithium is mediated by glycogen synthase kinase-3 inactivation and beta-catenin stabilization. Neuropharmacology 2008 Oct 10
17 19371592 Valproic acid enhances protein L-isoaspartyl methyltransferase expression by stimulating extracellular signal-regulated kinase signaling pathway. Neuropharmacology 2009 Apr 7
18 19801578 The V119I polymorphism in protein L-isoaspartate O-methyltransferase alters the substrate-binding interface. Protein Eng Des Sel 2009 Dec 3
19 20424163 Repair of isoaspartate formation modulates the interaction of deamidated 4E-BP2 with mTORC1 in brain. J Biol Chem 2010 Jun 18 5
20 20564550 The role of protein L-isoaspartyl/D-aspartyl O-methyltransferase (PIMT) in intracellular signal transduction. Chem Biodivers 2010 Jun 4
21 21204776 Damaged proteins bearing L-isoaspartyl residues and aging: a dynamic equilibrium between generation of isomerized forms and repair by PIMT. Curr Aging Sci 2011 Feb 2
22 21741329 Computational investigation of the substrate recognition mechanism of protein D-aspartyl (L-isoaspartyl) O-methyltransferase by docking and molecular dynamics simulation studies and application to interpret size exclusion chromatography data. J Chromatogr B Analyt Technol Biomed Life Sci 2011 Nov 1 9
23 21812329 Protein L-isoaspartyl O-methyltransferase inhibits amyloid beta fibrillogenesis in vitro. Pharmazie 2011 Jul 4
24 21841813 Cross-regulation between protein L-isoaspartyl O-methyltransferase and ERK in epithelial mesenchymal transition of MDA-MB-231 cells. Acta Pharmacol Sin 2011 Sep 1
25 22033921 The microRNA 15a/16-1 cluster down-regulates protein repair isoaspartyl methyltransferase in hepatoma cells: implications for apoptosis regulation. J Biol Chem 2011 Dec 23 1
26 22132761 Protein isoaspartate methyltransferase-mediated 18O-labeling of isoaspartic acid for mass spectrometry analysis. Anal Chem 2012 Jan 17 3
27 22382029 Requirement of protein l-isoaspartyl O-methyltransferase for transcriptional activation of trefoil factor 1 (TFF1) gene by estrogen receptor alpha. Biochem Biophys Res Commun 2012 Apr 6 2
28 22647835 Maternal PCMT1 gene polymorphisms and the risk of neural tube defects in a Chinese population of Lvliang high-risk area. Gene 2012 Sep 1 2
29 22735455 Protein L-isoaspartyl methyltransferase regulates p53 activity. Nat Commun 2012 Jun 26 2
30 23319267 Mitochondrial uncoupler carbonyl cyanide M-chlorophenylhydrazone induces the multimer assembly and activity of repair enzyme protein L-isoaspartyl methyltransferase. J Mol Neurosci 2013 Jul 20
31 23385093 Interconversion of the peptide isoforms of aspartate: stability of isoaspartates. Mech Ageing Dev 2013 Mar 3
32 23630590 Molecular ageing of alpha- and Beta-synucleins: protein damage and repair mechanisms. PLoS One 2013 2
33 23647599 Protein-L-isoaspartate (D-aspartate) O-methyltransferase protects cardiomyocytes against hypoxia induced apoptosis through inhibiting proapoptotic kinase Mst1. Int J Cardiol 2013 Oct 9 2
34 23918616 PCMT1 gene polymorphisms, maternal folate metabolism, and neural tube defects: a case-control study in a population with relatively low folate intake. Genes Nutr 2013 Nov 1
35 24044898 Accumulation of altered aspartyl residues in erythrocyte membrane proteins from patients with sporadic amyotrophic lateral sclerosis. Neurochem Int 2013 Nov 3
36 24631677 Dopamine down-regulation of protein L-isoaspartyl methyltransferase is dependent on reactive oxygen species in SH-SY5Y cells. Neuroscience 2014 May 16 20
37 25327473 Methylation of histone H4 at aspartate 24 by protein L-isoaspartate O-methyltransferase (PCMT1) links histone modifications with protein homeostasis. Sci Rep 2014 Oct 20 1
38 25479244 Rapid survey of four Asp isomers in disease-related proteins by LC-MS combined with commercial enzymes. Anal Chem 2015 Jan 6 4
39 25758062 Prediction of binding modes between protein L-isoaspartyl (D-aspartyl) O-methyltransferase and peptide substrates including isomerized aspartic acid residues using in silico analytic methods for the substrate screening. J Pharm Biomed Anal 2015 Dec 10 16
40 25800307 The protein l-isoaspartyl (d-aspartyl) methyltransferase protects against dopamine-induced apoptosis in neuroblastoma SH-SY5Y cells. Neuroscience 2015 Jun 4 5
41 29517839 PCMT1 is an unfavorable predictor and functions as an oncogene in bladder cancer. IUBMB Life 2018 Apr 1
42 29568357 Deficiency of protein-L-isoaspartate (D-aspartate) <i>O</i>-methyl-transferase expression under endoplasmic reticulum stress promotes epithelial mesenchymal transition in lung adenocarcinoma. Oncotarget 2018 Mar 2 1
43 29571628 Differences in α-Crystallin isomerization reveal the activity of protein isoaspartyl methyltransferase (PIMT) in the nucleus and cortex of human lenses. Exp Eye Res 2018 Jun 3
44 31342023 Two-dimensional polyimide heterojunctions for the efficient removal of environmental pollutants under visible-light irradiation. Phys Chem Chem Phys 2019 Aug 21 1
45 32207844 Carotid intima-media thickness (IMT) in patients with severe familial and non-familial hypercholesterolemia: The effect of measurement site on the IMT correlation with traditional cardiovascular risk factors and calcium scores. Cardiol J 2021 1
46 32705859 Neural stem cell conditioned medium alleviates Aβ&lt;sub&gt;25-35&lt;/sub&gt; damage to SH-SY5Y cells through the PCMT1/MST1 pathway. Eur J Histochem 2020 Jun 19 1
47 33054131 Protein-L-isoaspartate O-methyltransferase is required for &lt;i&gt;in vivo&lt;/i&gt; control of oxidative damage in red blood cells. Haematologica 2021 Oct 1 4
48 33857260 Isomerization of Asp is essential for assembly of amyloid-like fibrils of αA-crystallin-derived peptide. PLoS One 2021 2
49 34082401 The enzyme L-isoaspartyl (D-aspartyl) methyltransferase promotes migration and invasion in human U-87 MG and U-251 MG glioblastoma cell lines. Biomed Pharmacother 2021 Aug 2
50 35113558 PIMT-Mediated Labeling of l-Isoaspartic Acid with Tris Facilitates Identification of Isomerization Sites in Long-Lived Proteins. J Am Soc Mass Spectrom 2022 Mar 2 10