Rho GTPase activating protein 35 ; Homo sapiens






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1 7935432 p190 RhoGAP, the major RasGAP-associated protein, binds GTP directly. Mol Cell Biol 1994 Nov 1
2 9417037 Activation of beta1 integrin signaling stimulates tyrosine phosphorylation of p190RhoGAP and membrane-protrusive activities at invadopodia. J Biol Chem 1998 Jan 2 1
3 9482864 Evidence for distinct mechanisms of transition state stabilization of GTPases by fluoride. Proc Natl Acad Sci U S A 1998 Mar 3 4
4 10504326 Regulation of the RhoA pathway in human endothelial cell spreading on type IV collagen: role of calcium influx. J Cell Sci 1999 Oct 2
5 10591626 Src tyrosine kinase activity down-regulates Rho-dependent responses during Shigella entry into epithelial cells and stress fibre formation. J Cell Sci 2000 Jan 3
6 10713673 RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion. Oncogene 2000 Mar 2 1
7 10781817 Phosphorylation of the p190 RhoGAP N-terminal domain by c-Src results in a loss of GTP binding activity. FEBS Lett 2000 Apr 21 1
8 10873807 Integrin engagement suppresses RhoA activity via a c-Src-dependent mechanism. Curr Biol 2000 Jun 15 1
9 11309200 Phosphorylation of p190 on Tyr1105 by c-Src is necessary but not sufficient for EGF-induced actin disassembly in C3H10T1/2 fibroblasts. J Cell Sci 2001 May 6
10 11311150 Characterization of membrane-localized and cytosolic Rac-GTPase-activating proteins in human neutrophil granulocytes: contribution to the regulation of NADPH oxidase. Biochem J 2001 May 1 1
11 11342655 Role of p190RhoGAP in beta 2 integrin regulation of RhoA in human neutrophils. J Immunol 2001 May 15 4
12 11536198 Tyrosine phosphorylation of p190 RhoGAP by Fyn regulates oligodendrocyte differentiation. J Neurobiol 2001 Oct 1
13 11749381 c-Src tyrosine phosphorylation of epidermal growth factor receptor, P190 RhoGAP, and focal adhesion kinase regulates diverse cellular processes. Chem Rev 2001 Aug 1
14 12538643 RhoA is required for cortical retraction and rigidity during mitotic cell rounding. J Cell Biol 2003 Jan 20 2
15 12598902 Redox-dependent downregulation of Rho by Rac. Nat Cell Biol 2003 Mar 1
16 12606561 Cadherin engagement inhibits RhoA via p190RhoGAP. J Biol Chem 2003 Apr 18 1
17 12842009 Rnd proteins function as RhoA antagonists by activating p190 RhoGAP. Curr Biol 2003 Jul 1 2
18 14610059 p190RhoGAP is cell cycle regulated and affects cytokinesis. J Cell Biol 2003 Nov 10 4
19 14699145 Phospholipids can switch the GTPase substrate preference of a GTPase-activating protein. J Biol Chem 2004 Feb 13 3
20 15286003 Barrier dysfunction and RhoA activation are blunted by homocysteine and adenosine in pulmonary endothelium. Am J Physiol Lung Cell Mol Physiol 2004 Dec 4
21 16971514 Integrin signaling through Arg activates p190RhoGAP by promoting its binding to p120RasGAP and recruitment to the membrane. Mol Biol Cell 2006 Nov 1
22 17581634 The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN. EMBO J 2007 Jul 11 1
23 17652459 The Abl-related gene tyrosine kinase acts through p190RhoGAP to inhibit actomyosin contractility and regulate focal adhesion dynamics upon adhesion to fibronectin. Mol Biol Cell 2007 Oct 1
24 17706593 The receptor protein tyrosine phosphatase (RPTP)beta/zeta is expressed in different subtypes of human breast cancer. Biochem Biophys Res Commun 2007 Oct 12 1
25 18198190 Overexpression of EPHA2 receptor destabilizes adherens junctions via a RhoA-dependent mechanism. J Cell Sci 2008 Feb 1 1
26 18234668 HIV-1 Nef disrupts the podocyte actin cytoskeleton by interacting with diaphanous interacting protein. J Biol Chem 2008 Mar 28 2
27 18541700 p190RhoGAP is the convergence point of adhesion signals from alpha 5 beta 1 integrin and syndecan-4. J Cell Biol 2008 Jun 16 2
28 18566238 Synergistic effects of methylnaltrexone with 5-fluorouracil and bevacizumab on inhibition of vascular endothelial growth factor-induced angiogenesis. Mol Cancer Ther 2008 Jun 1
29 18660502 ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells. J Biol Chem 2008 Oct 3 2
30 18767036 Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal-transduction pathways. Int J Cancer 2008 Dec 1 1
31 19435801 A FAK-p120RasGAP-p190RhoGAP complex regulates polarity in migrating cells. J Cell Sci 2009 Jun 1 4
32 19649566 Aryl-hydrocarbon receptor-dependent alteration of FAK/RhoA in the inhibition of HUVEC motility by 3-methylcholanthrene. Cell Mol Life Sci 2009 Oct 1
33 20507639 Arecoline induces HA22T/VGH hepatoma cells to undergo anoikis - involvement of STAT3 and RhoA activation. Mol Cancer 2010 May 28 1
34 20579378 EGFR isoforms and gene regulation in human endometrial cancer cells. Mol Cancer 2010 Jun 25 1
35 20617170 HIV gp41 engages gC1qR on CD4+ T cells to induce the expression of an NK ligand through the PIP3/H2O2 pathway. PLoS Pathog 2010 Jul 1 2
36 20737438 The Abl and Arg non-receptor tyrosine kinases regulate different zones of stress fiber, focal adhesion, and contractile network localization in spreading fibroblasts. Cytoskeleton (Hoboken) 2010 Oct 4
37 21111731 p190RhoGAP mediates protective effects of oxidized phospholipids in the models of ventilator-induced lung injury. Exp Cell Res 2011 Apr 1 3
38 21779478 The Tumor Suppressor, p190RhoGAP, Differentially Initiates Apoptosis and Confers Docetaxel Sensitivity to Breast Cancer Cells. Genes Cancer 2011 Jan 3
39 21890632 Consensus substrate sequence for protein-tyrosine phosphatase receptor type Z. J Biol Chem 2011 Oct 28 1
40 22505611 Grb2 mediates semaphorin-4D-dependent RhoA inactivation. J Cell Sci 2012 Aug 1 1
41 23178654 Folic acid inhibits endothelial cell migration through inhibiting the RhoA activity mediated by activating the folic acid receptor/cSrc/p190RhoGAP-signaling pathway. Biochem Pharmacol 2013 Feb 1 1
42 23499677 p190RhoGAP has cellular RacGAP activity regulated by a polybasic region. Cell Signal 2013 Jun 2
43 23524135 The reorientation of cell nucleus promotes the establishment of front-rear polarity in migrating fibroblasts. J Mol Biol 2013 Jun 12 2
44 23707396 One isoform of Arg/Abl2 tyrosine kinase is nuclear and the other seven cytosolic isoforms differently modulate cell morphology, motility and the cytoskeleton. Exp Cell Res 2013 Aug 1 1
45 24759231 Gleevec/imatinib, an ABL2 kinase inhibitor, protects tumor and endothelial cells from semaphorin-induced cytoskeleton collapse and loss of cell motility. Biochem Biophys Res Commun 2014 May 30 1
46 25025568 A Blk-p190RhoGAP signaling module downstream of activated Gα13 functionally opposes CXCL12-stimulated RhoA activation and cell invasion. Cell Signal 2014 Nov 2
47 25359885 A complex of p190RhoGAP-A and anillin modulates RhoA-GTP and the cytokinetic furrow in human cells. J Cell Sci 2015 Jan 1 7
48 26887829 Melanocortin 1 receptor agonist protects podocytes through catalase and RhoA activation. Am J Physiol Renal Physiol 2016 May 1 1
49 27298228 Arg tyrosine kinase modulates TGF-β1 production in human renal tubular cells under high-glucose conditions. J Cell Sci 2016 Aug 1 3
50 29107098 Corticosteroid-induced dendrite loss and behavioral deficiencies can be blocked by activation of Abl2/Arg kinase. Mol Cell Neurosci 2017 Dec 1