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| 2 | 16054069 | The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. | Cell Metab | 2005 Apr |
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| 3 | 16267104 | Mouse GPR40 heterologously expressed in Xenopus oocytes is activated by short-, medium-, and long-chain fatty acids. | Am J Physiol Cell Physiol | 2006 Mar |
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| 4 | 16702987 | Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules. | Br J Pharmacol | 2006 Jul |
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| 5 | 17214971 | GPR40 is expressed in glucagon producing cells and affects glucagon secretion. | Biochem Biophys Res Commun | 2007 Mar 2 |
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| 6 | 17395749 | GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo. | Diabetes | 2007 Apr |
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| 7 | 17500511 | Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of G protein-coupled receptor 40 agonists. | J Med Chem | 2007 Jun 14 |
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| 8 | 17556534 | The role of G protein-coupled receptor 40 in lipoapoptosis in mouse beta-cell line NIT-1. | J Mol Endocrinol | 2007 Jun |
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| 9 | 18477808 | Selective small-molecule agonists of G protein-coupled receptor 40 promote glucose-dependent insulin secretion and reduce blood glucose in mice. | Diabetes | 2008 Aug |
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| 10 | 18478115 | Palmitate-induced beta-cell dysfunction is associated with excessive NO production and is reversed by thiazolidinedione-mediated inhibition of GPR40 transduction mechanisms. | PLoS One | 2008 May 14 |
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| 11 | 18519800 | Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion. | Diabetes | 2008 Sep |
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| 12 | 18559658 | The fatty acid receptor GPR40 plays a role in insulin secretion in vivo after high-fat feeding. | Diabetes | 2008 Sep |
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| 13 | 18617622 | Modulation of osteoclastogenesis by fatty acids. | Endocrinology | 2008 Nov |
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| 14 | 18678612 | Lack of FFAR1/GPR40 does not protect mice from high-fat diet-induced metabolic disease. | Diabetes | 2008 Nov |
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| 15 | 18793167 | The long-chain fatty acid receptor, GPR40, and glucolipotoxicity: investigations using GPR40-knockout mice. | Biochem Soc Trans | 2008 Oct |
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| 16 | 18927207 | Flow cytometry-based binding assay for GPR40 (FFAR1; free fatty acid receptor 1). | Mol Pharmacol | 2009 Jan |
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| 17 | 19369060 | Effects of long-term soluble vs. insoluble dietary fiber intake on high-fat diet-induced obesity in C57BL/6J mice. | J Nutr Biochem | 2010 Apr |
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| 18 | 19401434 | Overexpression of GPR40 in pancreatic beta-cells augments glucose-stimulated insulin secretion and improves glucose tolerance in normal and diabetic mice. | Diabetes | 2009 May |
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| 19 | 19471906 | Novel selective ligands for free fatty acid receptors GPR120 and GPR40. | Naunyn Schmiedebergs Arch Pharmacol | 2009 Sep |
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| 20 | 19720802 | Deletion of GPR40 impairs glucose-induced insulin secretion in vivo in mice without affecting intracellular fuel metabolism in islets. | Diabetes | 2009 Nov |
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| 21 | 19818732 | A novel class of antagonists for the FFAs receptor GPR40. | Biochem Biophys Res Commun | 2009 Dec 18 |
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| 22 | 20064714 | Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists. | Bioorg Med Chem Lett | 2010 Feb 1 |
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| 23 | 20416356 | GPR40 is partially required for insulin secretion following activation of beta3-adrenergic receptors. | Mol Cell Endocrinol | 2010 Aug 30 |
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| 24 | 20573884 | Taste preference for fatty acids is mediated by GPR40 and GPR120. | J Neurosci | 2010 Jun 23 |
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| 25 | 20955703 | The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin. | Gastroenterology | 2011 Mar |
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| 26 | 21514824 | 3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists. | Bioorg Med Chem Lett | 2011 Jun 1 |
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| 27 | 22137657 | Involvement of the long-chain fatty acid receptor GPR40 as a novel pain regulatory system. | Brain Res | 2012 Jan 13 |
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| 28 | 22275065 | Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis. | J Cell Biochem | 2012 Apr |
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| 29 | 22768248 | Sensing of fatty acids for octanoylation of ghrelin involves a gustatory G-protein. | PLoS One | 2012 |
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| 30 | 22820510 | G protein-coupled receptor (GPR)40-dependent potentiation of insulin secretion in mouse islets is mediated by protein kinase D1. | Diabetologia | 2012 Oct |
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| 31 | 22876318 | Duodenal enteroendocrine I-cells contain mRNA transcripts encoding key endocannabinoid and fatty acid receptors. | PLoS One | 2012 |
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| 32 | 23056280 | A potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents. | PLoS One | 2012 |
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| 33 | 23294321 | Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability. | J Med Chem | 2013 Feb 14 |
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| 34 | 23331570 | Lack of GPR40/FFAR1 does not induce diabetes even under insulin resistance condition. | Diabetes Obes Metab | 2013 Jun |
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| 35 | 23335512 | The free fatty acid receptor G protein-coupled receptor 40 (GPR40) protects from bone loss through inhibition of osteoclast differentiation. | J Biol Chem | 2013 Mar 1 |
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| 36 | 23341496 | Multiple mechanisms of GW-9508, a selective G protein-coupled receptor 40 agonist, in the regulation of glucose homeostasis and insulin sensitivity. | Am J Physiol Endocrinol Metab | 2013 Mar 15 |
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| 37 | 23403053 | Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1. | Mol Cell Endocrinol | 2013 Apr 30 |
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| 38 | 23520164 | Fatty acid receptor Gpr40 mediates neuromicrovascular degeneration induced by transarachidonic acids in rodents. | Arterioscler Thromb Vasc Biol | 2013 May |
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| 39 | 23687558 | Discovery of TUG-770: A Highly Potent Free Fatty Acid Receptor 1 (FFA1/GPR40) Agonist for Treatment of Type 2 Diabetes. | ACS Med Chem Lett | 2013 May 9 |
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| 40 | 23776696 | DC260126: a small-molecule antagonist of GPR40 that protects against pancreatic β-Cells dysfunction in db/db mice. | PLoS One | 2013 |
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| 41 | 23831422 | Activation of tongue-expressed GPR40 and GPR120 by non caloric agonists is not sufficient to drive preference in mice. | Neuroscience | 2013 Oct 10 |
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| 42 | 23853170 | Chronic treatment with novel GPR40 agonists improve whole-body glucose metabolism based on the glucose-dependent insulin secretion. | J Pharmacol Exp Ther | 2013 Sep |
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| 43 | 23861168 | In vitro and mouse in vivo characterization of the potent free fatty acid 1 receptor agonist TUG-469. | Naunyn Schmiedebergs Arch Pharmacol | 2013 Dec |
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| 44 | 23995397 | Exendin-4 protects pancreatic beta cells from palmitate-induced apoptosis by interfering with GPR40 and the MKK4/7 stress kinase signalling pathway. | Diabetologia | 2013 Nov |
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| 45 | 24130766 | A novel antidiabetic drug, fasiglifam/TAK-875, acts as an ago-allosteric modulator of FFAR1. | PLoS One | 2013 |
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| 46 | 24154510 | GPR40 and GPR120 fatty acid sensors are critical for postoral but not oral mediation of fat preferences in the mouse. | Am J Physiol Regul Integr Comp Physiol | 2013 Dec 15 |
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| 47 | 24269216 | Novel GPR40 agonist AS2575959 exhibits glucose metabolism improvement and synergistic effect with sitagliptin on insulin and incretin secretion. | Life Sci | 2014 Jan 17 |
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| 48 | 24349089 | Hypothalamic GPR40 signaling activated by free long chain fatty acids suppresses CFA-induced inflammatory chronic pain. | PLoS One | 2013 |
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| 49 | 24360748 | The effect of FFAR1 on pioglitazone-mediated attenuation of palmitic acid-induced oxidative stress and apoptosis in βTC6 cells. | Metabolism | 2014 Mar |
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| 50 | 24550142 | GPR40 activation leads to CREB and ERK phosphorylation in primary cultures of neurons from the mouse CNS and in human neuroblastoma cells. | Hippocampus | 2014 Jul |
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