fibroblast growth factor 21 ; Mus musculus






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1 15902306 FGF-21 as a novel metabolic regulator. J Clin Invest 2005 Jun 3
2 16929488 Forced expression of hepatocyte-specific fibroblast growth factor 21 delays initiation of chemically induced hepatocarcinogenesis. Mol Carcinog 2006 Dec 2
3 16936195 Fibroblast growth factor-21 improves pancreatic beta-cell function and survival by activation of extracellular signal-regulated kinase 1/2 and Akt signaling pathways. Diabetes 2006 Sep 3
4 17452648 BetaKlotho is required for metabolic activity of fibroblast growth factor 21. Proc Natl Acad Sci U S A 2007 May 1 3
5 17550778 Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab 2007 Jun 3
6 18187602 betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol Endocrinol 2008 Apr 2
7 18840432 Circadian expression of FGF21 is induced by PPARalpha activation in the mouse liver. FEBS Lett 2008 Oct 29 3
8 18840786 Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice. Diabetes 2009 Jan 3
9 18948104 FGF21 is an Akt-regulated myokine. FEBS Lett 2008 Nov 12 1
10 19470704 Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity. Endocrinology 2009 Sep 5
11 19531026 The role of fibroblast growth factor 21 (FGF21) on energy balance, glucose and lipid metabolism. Curr Diabetes Rev 2009 Nov 1
12 19541642 FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc Natl Acad Sci U S A 2009 Jun 30 8
13 19589869 Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver. Endocrinology 2009 Oct 5
14 19660458 Glucose induces FGF21 mRNA expression through ChREBP activation in rat hepatocytes. FEBS Lett 2009 Sep 3 1
15 19664632 Fibroblast growth factor 21 reduces the severity of cerulein-induced pancreatitis in mice. Gastroenterology 2009 Nov 3
16 19706786 Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects. Am J Physiol Endocrinol Metab 2009 Nov 4
17 19751733 Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice. FEBS Lett 2009 Oct 6 4
18 19819944 Fibroblast growth factor 21-deficient mice demonstrate impaired adaptation to ketosis. Endocrinology 2009 Nov 2
19 19906798 Fibroblast growth factor 21: from pharmacology to physiology. Am J Clin Nutr 2010 Jan 2
20 20018698 PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis. Proc Natl Acad Sci U S A 2009 Dec 29 3
21 20018895 FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation. J Biol Chem 2010 Feb 19 1
22 20197053 Hepatic FGF21 expression is induced at birth via PPARalpha in response to milk intake and contributes to thermogenic activation of neonatal brown fat. Cell Metab 2010 Mar 3 2
23 20236931 Thyroid hormone regulates hepatic expression of fibroblast growth factor 21 in a PPARalpha-dependent manner. J Biol Chem 2010 May 7 4
24 20424589 FGF21 is dispensable for hypothermia induced by fasting in mice. Neuro Endocrinol Lett 2010 1
25 20616029 Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway. Proc Natl Acad Sci U S A 2010 Jul 13 4
26 20663988 Glucagon and lipid interactions in the regulation of hepatic AMPK signaling and expression of PPARalpha and FGF21 transcripts in vivo. Am J Physiol Endocrinol Metab 2010 Oct 4
27 20682689 Obesity is a fibroblast growth factor 21 (FGF21)-resistant state. Diabetes 2010 Nov 6
28 20735016 Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ. ACS Chem Biol 2010 Nov 19 1
29 20851878 Transcriptional repressor E4-binding protein 4 (E4BP4) regulates metabolic hormone fibroblast growth factor 21 (FGF21) during circadian cycles and feeding. J Biol Chem 2010 Nov 19 2
30 21293445 Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice. Obesity (Silver Spring) 2011 Jul 7
31 21331285 FGF21 as an Endocrine Regulator in Lipid Metabolism: From Molecular Evolution to Physiology and Pathophysiology. J Nutr Metab 2011 1
32 21346090 Fibroblast growth factor 21 is a metabolic regulator that plays a role in the adaptation to ketosis. Am J Clin Nutr 2011 Apr 5
33 21373720 Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21. Mol Med 2011 2
34 21696361 FGF10 and FGF21 as regulators in adipocyte development and metabolism. Endocr Metab Immune Disord Drug Targets 2011 Dec 1
35 21712364 Integrated regulation of hepatic metabolism by fibroblast growth factor 21 (FGF21) in vivo. Endocrinology 2011 Aug 2
36 21720023 Thiazolidinediones are potent inducers of fibroblast growth factor 21 expression in the liver. Biol Pharm Bull 2011 6
37 21767451 Conjugated linoleic acid induces hepatic expression of fibroblast growth factor 21 through PPAR-α. Br J Nutr 2012 Feb 8
38 21829679 Paradoxical regulation of human FGF21 by both fasting and feeding signals: is FGF21 a nutritional adaptation factor? PLoS One 2011 2
39 21846717 Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes. J Biol Chem 2011 Oct 7 6
40 21849508 Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes. J Biol Chem 2011 Oct 7 2
41 21956711 Exenatide decreases hepatic fibroblast growth factor 21 resistance in non-alcoholic fatty liver disease in a mouse model of obesity and in a randomised controlled trial. Diabetologia 2011 Dec 1
42 22007513 [Establishment of a novel cell model targeted on FGF-21 receptor for screening anti-diabetic drug candidates]. Yao Xue Xue Bao 2011 Aug 1
43 22012983 Effect of bezafibrate treatment on late-onset mitochondrial myopathy in mice. Hum Mol Genet 2012 Feb 1 1
44 22067317 Lack of overt FGF21 resistance in two mouse models of obesity and insulin resistance. Endocrinology 2012 Jan 2
45 22174314 Amelioration of type 2 diabetes by antibody-mediated activation of fibroblast growth factor receptor 1. Sci Transl Med 2011 Dec 14 1
46 22304921 Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones. Cell 2012 Feb 3 4
47 22338096 Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3. Diabetes 2012 Apr 17
48 22370560 A unique FGF23 with the ability to activate FGFR signaling through both αKlotho and βKlotho. J Mol Biol 2012 Apr 20 1
49 22474187 FGF21 is increased by inflammatory stimuli and protects leptin-deficient ob/ob mice from the toxicity of sepsis. Endocrinology 2012 Jun 10
50 22653558 Chronic prednisolone treatment aggravates hyperglycemia in mice fed a high-fat diet but does not worsen dietary fat-induced insulin resistance. Endocrinology 2012 Aug 2