RAS p21 protein activator 1 ; Homo sapiens






156 Article(s)
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1 1374686 Molecular cloning and nucleic acid binding properties of the GAP-associated tyrosine phosphoprotein p62. Cell 1992 May 1 1
2 1569084 Erythropoietin induces p21ras activation and p120GAP tyrosine phosphorylation in human erythroleukemia cells. J Biol Chem 1992 Apr 25 2
3 1633149 Binding of the H-ras p21 GTPase activating protein by the activated epidermal growth factor receptor leads to inhibition of the p21 GTPase activity in vitro. Biochemistry 1992 Jul 21 1
4 1939245 Rap1A antagonizes the ability of Ras and Ras-Gap to inhibit muscarinic K+ channels. J Biol Chem 1991 Nov 25 4
5 2115644 Amino acid 61 is a determinant of sensitivity of rap proteins to the ras GTPase activating protein. Oncogene 1990 Jul 2
6 7492562 Kinetics of inorganic phosphate release during the interaction of p21ras with the GTPase-activating proteins, p120-GAP and neurofibromin. Biochemistry 1995 Nov 28 2
7 7499225 A conserved region of c-Ha-Ras is required for efficient GTPase stimulation by GTPase activating protein but not neurofibromin. J Biol Chem 1995 Nov 17 1
8 7516336 Incorporation of Rap 1b into the platelet cytoskeleton is dependent on thrombin activation and extracellular calcium. J Biol Chem 1994 Jun 24 1
9 7544452 Calcium induces tyrosine phosphorylation of a novel p120GAP-associated protein of 65 kDa. Oncogene 1995 Aug 17 6
10 7629101 Two SH2 domains of p120 Ras GTPase-activating protein bind synergistically to tyrosine phosphorylated p190 Rho GTPase-activating protein. J Biol Chem 1995 Jul 28 4
11 7733887 Mutation-deletion analysis of a Ca(2+)-dependent phospholipid binding (CaLB) domain within p120 GAP, a GTPase-activating protein for p21 ras. Biochem J 1995 Apr 15 4
12 7756172 Changes in tyrosine-phosphorylated p190 and its association with p120 type I and p100 type II rasGAPs during myelomonocytic differentiation of human leukemic cells. Cell Growth Differ 1995 Feb 5
13 7898923 CaLB: a 43 amino acid calcium-dependent membrane/phospholipid binding domain in p120 Ras GTPase-activating protein. Oncogene 1995 Mar 2 4
14 7935432 p190 RhoGAP, the major RasGAP-associated protein, binds GTP directly. Mol Cell Biol 1994 Nov 1
15 8195713 Negative regulation of p120GAP GTPase promoting activity by p210bcr/abl: implication for RAS-dependent Philadelphia chromosome positive cell growth. J Exp Med 1994 Jun 1 3
16 8262937 Kinetics of interaction between normal and proline 12 Ras and the GTPase-activating proteins, p120-GAP and neurofibromin. The significance of the intrinsic GTPase rate in determining the transforming ability of ras. J Biol Chem 1993 Dec 25 7
17 8270251 Genetic analysis of the catalytic domain of the GAP gene in human lung cancer cell lines. Hum Genet 1994 Jan 1
18 8335107 Differential contribution of M(r) 120 kDa rasGTPase-activating protein and neurofibromatosis type 1 gene product during the transition from growth phase to arrested state in human fibroblasts accompanied by a unique rasGTPase-activating activity. FEBS Lett 1993 Jul 26 1
19 8338843 Mechanism of GTP hydrolysis by p21N-ras catalyzed by GAP: studies with a fluorescent GTP analogue. Biochemistry 1993 Jul 27 4
20 8570203 Association of CD45 with Lck and components of the Ras signalling pathway in pervanadate-treated mouse T-cell lines. Oncogene 1996 Jan 18 1
21 8607981 Interactions between Ras and Raf: key regulatory proteins in cellular transformation. Mol Reprod Dev 1995 Dec 1
22 8621595 Enhancement of protein kinase C-dependent O2 production in Epstein-Barr virus-transformed B lymphocytes by p120Ras-GAP antisense oligonucleotide. J Biol Chem 1996 Apr 19 6
23 8637231 c-kit ligand stimulates tyrosine phosphorylation of a similar pattern of phosphotyrosyl proteins in primary primitive normal hematopoietic progenitors that are constitutively phosphorylated in comparable primitive progenitors in chronic phase chronic myelogenous leukemia. Leukemia 1996 Feb 1
24 8658179 Formation of a transition-state analog of the Ras GTPase reaction by Ras-GDP, tetrafluoroaluminate, and GTPase-activating proteins. Science 1996 Jul 5 2
25 8714559 The PH domain of Ras-GAP is sufficient for in vitro binding to beta gamma subunits of heterotrimeric G proteins. Cell Mol Neurobiol 1996 Feb 1
26 8738474 The role of ras GTPase activating protein in human tumorigenesis. Pathobiology 1995 1
27 8816504 Platelet-derived growth factor-dependent activation of phosphatidylinositol 3-kinase is regulated by receptor binding of SH2-domain-containing proteins which influence Ras activity. Mol Cell Biol 1996 Oct 1
28 8828816 Characterization of the C-terminal domain of ras-GTPase-activating protein (ras-GAP) as substrate for epidermal growth factor receptor and p60c-src kinase. Biochem Mol Biol Int 1996 Jun 4
29 8858112 Phosphorothioate-capped antisense oligonucleotides to Ras GAP inhibit cell proliferation and trigger apoptosis but fail to downregulate GAP gene expression. Biochem Biophys Res Commun 1996 Oct 3 3
30 8909796 Control of ras activation. Cancer Surv 1996 6
31 9034330 Tandem SH2 binding sites mediate the RasGAP-RhoGAP interaction: a conformational mechanism for SH3 domain regulation. EMBO J 1997 Feb 3 1
32 9102473 The role of the metal ion in the p21ras catalysed GTP-hydrolysis: Mn2+ versus Mg2+. J Mol Biol 1997 Mar 7 4
33 9219684 The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science 1997 Jul 18 2
34 9235929 Activation of R-Ras GTPase by GTPase-activating proteins for Ras, Gap1(m), and p120GAP. J Biol Chem 1997 Aug 1 3
35 9255347 [Isoprenylated proteins and cell proliferation: regulators and effectors of Ras proteins]. C R Seances Soc Biol Fil 1997 1
36 9312123 A new function of p120-GTPase-activating protein. Prevention of the guanine nucleotide exchange factor-stimulated nucleotide exchange on the active form of Ha-ras p21. J Biol Chem 1997 Oct 3 6
37 9528773 Activation of Src family members is not required for the platelet-derived growth factor beta receptor to initiate mitogenesis. Mol Cell Biol 1998 Apr 1
38 9545275 The importance of two conserved arginine residues for catalysis by the ras GTPase-activating protein, neurofibromin. J Biol Chem 1998 Apr 17 1
39 9546424 Identification of Tyr-762 in the platelet-derived growth factor alpha-receptor as the binding site for Crk proteins. Oncogene 1998 Mar 12 2
40 9553053 Catalytic domain of the p120 Ras GAP binds to RAb5 and stimulates its GTPase activity. J Biol Chem 1998 Apr 24 1
41 9599009 Sequence and 3D structural relationships between mammalian Ras- and Rho-specific GTPase-activating proteins (GAPs): the cradle fold. FEBS Lett 1998 Apr 17 1
42 9731575 Altered regulation of Src tyrosine kinase by transforming growth factor beta1 in a human hepatoma cell line. Hepatology 1998 Sep 2
43 9778042 Sulindac sulfide inhibits Ras signaling. Oncogene 1998 Oct 8 1
44 10200531 Proteolytic cleavage of ras GTPase-activating protein during apoptosis. Cell Death Differ 1998 Sep 1
45 10202139 Tyrosine phosphorylation of p62(Dok) induced by cell adhesion and insulin: possible role in cell migration. EMBO J 1999 Apr 1 1
46 10319320 16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells. Mol Endocrinol 1999 May 1
47 10391888 Integrins enhance platelet-derived growth factor (PDGF)-dependent responses by altering the signal relay enzymes that are recruited to the PDGF beta receptor. J Biol Chem 1999 Jul 9 2
48 10448070 Enhanced phosphatidylinositol 3-kinase activity and high phosphorylation state of its downstream signalling molecules mediated by ret with the MEN 2B mutation. Biochem Biophys Res Commun 1999 Aug 19 2
49 10559409 Platelet-derived growth factor-mediated signal transduction underlying astrocyte proliferation: site of ethanol action. J Neurosci 1999 Nov 15 2
50 10567236 Platelet-derived growth factor-dependent association of the GTPase-activating protein of Ras and Src. Biochem J 1999 Dec 1 6