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| 2 | 9802331 | Reduced cholesterol accumulation and improved deficient peroxisomal functions in a murine model of Niemann-Pick type C disease upon treatment with peroxisomal proliferators. | Biochem Pharmacol | 1998 Nov 1 |
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| 3 | 9854040 | Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N). | J Clin Invest | 1998 Dec 15 |
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| 4 | 11358865 | SREBP cleavage-activating protein (SCAP) is required for increased lipid synthesis in liver induced by cholesterol deprivation and insulin elevation. | Genes Dev | 2001 May 15 |
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| 5 | 11820817 | Distinct consequences of sterol sensor mutations in Drosophila and mouse patched homologs. | Dev Biol | 2002 Feb 15 |
3 |
| 6 | 14512514 | Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes. | Proc Natl Acad Sci U S A | 2003 Oct 14 |
1 |
| 7 | 15625683 | Comparison of osteoblast responses to hydroxyapatite and hydroxyapatite/soluble calcium phosphate composites. | J Biomed Mater Res A | 2005 Feb 1 |
2 |
| 8 | 16054043 | Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver. | Cell Metab | 2005 Jan |
6 |
| 9 | 17609412 | Characterization of ScAP-23, a new cell line from murine subcutaneous adipose tissue, identifies genes for the molecular definition of preadipocytes. | Physiol Genomics | 2007 Oct 22 |
3 |
| 10 | 18974038 | Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL. | J Lipid Res | 2009 Apr |
3 |
| 11 | 19074148 | Deletion of Scap in alveolar type II cells influences lung lipid homeostasis and identifies a compensatory role for pulmonary lipofibroblasts. | J Biol Chem | 2009 Feb 6 |
2 |
| 12 | 19716478 | A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. | Chem Biol | 2009 Aug 28 |
2 |
| 13 | 19948958 | SCAP is required for timely and proper myelin membrane synthesis. | Proc Natl Acad Sci U S A | 2009 Dec 15 |
2 |
| 14 | 20083572 | Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI. | Cardiovasc Res | 2010 Jun 1 |
1 |
| 15 | 22326225 | The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals. | Cell Metab | 2012 Feb 8 |
2 |
| 16 | 22751013 | High-fat diet ameliorates neurological deficits caused by defective astrocyte lipid metabolism. | FASEB J | 2012 Oct |
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| 17 | 23227865 | Mitochondrial function is involved in regulation of cholesterol efflux to apolipoprotein (apo)A-I from murine RAW 264.7 macrophages. | Lipids Health Dis | 2012 Dec 10 |
1 |
| 18 | 23585733 | Reduction of the cholesterol sensor SCAP in the brains of mice causes impaired synaptic transmission and altered cognitive function. | PLoS Biol | 2013 |
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| 19 | 23832448 | Free cholesterol accumulation in hepatic stellate cells: mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice. | Hepatology | 2014 Jan |
2 |
| 20 | 23868406 | Advanced glycation end products promote hepatosteatosis by interfering with SCAP-SREBP pathway in fructose-drinking mice. | Am J Physiol Gastrointest Liver Physiol | 2013 Sep 15 |
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| 21 | 24144758 | [Human stem cells from apical papilla can regenerate dentin-pulp complex]. | Nan Fang Yi Ke Da Xue Xue Bao | 2013 Oct |
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| 22 | 24756434 | Distal-less homeobox 2 promotes the osteogenic differentiation potential of stem cells from apical papilla. | Cell Tissue Res | 2014 Jul |
1 |
| 23 | 24789999 | Ginsenoside F2 reduces hair loss by controlling apoptosis through the sterol regulatory element-binding protein cleavage activating protein and transforming growth factor-β pathways in a dihydrotestosterone-induced mouse model. | Biol Pharm Bull | 2014 |
4 |
| 24 | 25896350 | Scap is required for sterol synthesis and crypt growth in intestinal mucosa. | J Lipid Res | 2015 Aug |
8 |
| 25 | 26305254 | Apple Polyphenols Decrease Atherosclerosis and Hepatic Steatosis in ApoE-/- Mice through the ROS/MAPK/NF-κB Pathway. | Nutrients | 2015 Aug 24 |
1 |
| 26 | 27477273 | Feedback Loop Regulation of SCAP/SREBP-1 by miR-29 Modulates EGFR Signaling-Driven Glioblastoma Growth. | Cell Rep | 2016 Aug 9 |
4 |
| 27 | 27601673 | SCAP/SREBP pathway is required for the full steroidogenic response to cyclic AMP. | Proc Natl Acad Sci U S A | 2016 Sep 20 |
8 |
| 28 | 28168742 | Astrocyte lipid metabolism is critical for synapse development and function in vivo. | Glia | 2017 Apr |
4 |
| 29 | 28491104 | Effect of Tetramethylpyrazine on Atherosclerosis and SCAP/SREBP-1c Signaling Pathway in ApoE<sup>-/-</sup> Mice Fed with a High-Fat Diet. | Evid Based Complement Alternat Med | 2017 |
2 |
| 30 | 29068315 | Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP. | Elife | 2017 Oct 25 |
2 |
| 31 | 29342166 | Effects of vitamin D on insulin resistance and myosteatosis in diet-induced obese mice. | PLoS One | 2018 |
3 |
| 32 | 29899135 | Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis. | Development | 2018 Jul 9 |
1 |
| 33 | 30462530 | SCAP knockdown in vascular smooth muscle cells alleviates atherosclerosis plaque formation via up-regulating autophagy in ApoE<sup>-/-</sup> mice. | FASEB J | 2019 Mar |
3 |
| 34 | 31239739 | Quercetin improves lipid metabolism via SCAP-SREBP2-LDLr signaling pathway in early stage diabetic nephropathy. | Diabetes Metab Syndr Obes | 2019 |
2 |
| 35 | 31327168 | Industrial Trans Fatty Acids Stimulate SREBP2-Mediated Cholesterogenesis and Promote Non-Alcoholic Fatty Liver Disease. | Mol Nutr Food Res | 2019 Oct |
7 |
| 36 | 32385422 | The cellular function of SCAP in metabolic signaling. | Exp Mol Med | 2020 May |
3 |
| 37 | 32432943 | Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway. | Autophagy | 2021 Jul |
6 |
| 38 | 32859645 | Hepatic deletion of Mboat7 (LPIAT1) causes activation of SREBP-1c and fatty liver. | J Lipid Res | 2021 |
2 |
| 39 | 33139746 | Effects of high-fat diet and Apoe deficiency on retinal structure and function in mice. | Sci Rep | 2020 Nov 2 |
1 |
| 40 | 33227706 | SCAP knockout in SM22α-Cre mice induces defective angiogenesis in the placental labyrinth. | Biomed Pharmacother | 2021 Jan |
4 |
| 41 | 33631226 | Hyperphosphatemia in chronic kidney disease exacerbates atherosclerosis via a mannosidases-mediated complex-type conversion of SCAP N-glycans. | Kidney Int | 2021 Jun |
5 |
| 42 | 34060475 | DHT causes liver steatosis via transcriptional regulation of SCAP in normal weight female mice. | J Endocrinol | 2021 Jun 28 |
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| 43 | 34094640 | Sterol-resistant SCAP Overexpression in Vascular Smooth Muscle Cells Accelerates Atherosclerosis by Increasing Local Vascular Inflammation through Activation of the NLRP3 Inflammasome in Mice. | Aging Dis | 2021 Jun |
2 |
| 44 | 34431998 | LH Induces De Novo Cholesterol Biosynthesis via SREBP Activation in Granulosa Cells During Ovulation in Female Mice. | Endocrinology | 2021 Nov 1 |
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| 45 | 34606256 | Role of Thioredoxin-Interacting Protein in Diabetic Fatty Kidney Induced by Advanced Glycation End-Products. | J Agric Food Chem | 2021 Oct 13 |
1 |
| 46 | 35354475 | Cholesterol sensor SCAP contributes to sorafenib resistance by regulating autophagy in hepatocellular carcinoma. | J Exp Clin Cancer Res | 2022 Mar 30 |
10 |
| 47 | 35367665 | Macrophage SCAP Contributes to Metaflammation and Lean NAFLD by Activating STING-NF-κB Signaling Pathway. | Cell Mol Gastroenterol Hepatol | 2022 |
3 |
| 48 | 35380992 | Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis. | J Clin Invest | 2022 Jun 1 |
4 |