activating transcription factor 6 ; Homo sapiens






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1 10866666 ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1. Mol Cell Biol 2000 Jul 8
2 10958673 ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response. Mol Cell Biol 2000 Sep 2
3 11112790 Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response. J Biol Chem 2001 Mar 23 1
4 11158310 Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response. Mol Cell Biol 2001 Feb 2
5 11163209 ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs. Mol Cell 2000 Dec 3
6 11493036 Endoproteolysis of the ER stress transducer ATF6 in the presence of functionally inactive presenilins. Neurobiol Dis 2001 Aug 1
7 12076252 Requirement of the p38 mitogen-activated protein kinase signalling pathway for the induction of the 78 kDa glucose-regulated protein/immunoglobulin heavy-chain binding protein by azetidine stress: activating transcription factor 6 as a target for stress-induced phosphorylation. Biochem J 2002 Sep 15 4
8 12782636 A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6. J Biol Chem 2003 Aug 15 7
9 12949534 Impaired feedback regulation of XBP1 as a genetic risk factor for bipolar disorder. Nat Genet 2003 Oct 1
10 14699159 Underglycosylation of ATF6 as a novel sensing mechanism for activation of the unfolded protein response. J Biol Chem 2004 Mar 19 3
11 14765107 ATF6 modulates SREBP2-mediated lipogenesis. EMBO J 2004 Feb 25 1
12 14973138 Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction. J Biol Chem 2004 May 14 1
13 15211570 Endoplasmic reticulum stress triggers an acute proteasome-dependent degradation of ATF6. J Cell Biochem 2004 Jul 1 1
14 15657421 Stable binding of ATF6 to BiP in the endoplasmic reticulum stress response. Mol Cell Biol 2005 Feb 1
15 15799970 The unfolded protein response modulates toxicity of the expanded glutamine androgen receptor. J Biol Chem 2005 Jun 3 3
16 15867268 Riboflavin deficiency impairs oxidative folding and secretion of apolipoprotein B-100 in HepG2 cells, triggering stress response systems. J Nutr 2005 May 1
17 16236796 CREB4, a transmembrane bZip transcription factor and potential new substrate for regulation and cleavage by S1P. Mol Biol Cell 2006 Jan 1
18 16364319 Transformation-associated gene regulation by ATF6alpha during hepatocarcinogenesis. FEBS Lett 2006 Jan 9 1
19 16790437 The proprotein convertase SKI-1/S1P. In vitro analysis of Lassa virus glycoprotein-derived substrates and ex vivo validation of irreversible peptide inhibitors. J Biol Chem 2006 Aug 18 1
20 17101776 Role of disulfide bridges formed in the luminal domain of ATF6 in sensing endoplasmic reticulum stress. Mol Cell Biol 2007 Feb 7
21 17130669 Reduction of disulfide bridges in the lumenal domain of ATF6 in response to glucose starvation. Cell Struct Funct 2006 4
22 17167033 Up-regulation of 150-kDa oxygen-regulated protein by celecoxib in human gastric carcinoma cells. Mol Pharmacol 2007 Mar 5
23 17307147 Transcriptional activation of ATF6 by endoplasmic reticulum stressors. Biochem Biophys Res Commun 2007 Apr 6 2
24 17341418 Indomethacin induces apoptosis in 786-O renal cell carcinoma cells by activating mitogen-activated protein kinases and AKT. Eur J Pharmacol 2007 Jun 1 1
25 17440018 Activating transcription factor 6 polymorphisms and haplotypes are associated with impaired glucose homeostasis and type 2 diabetes in Dutch Caucasians. J Clin Endocrinol Metab 2007 Jul 1
26 17522056 Effects of the isoform-specific characteristics of ATF6 alpha and ATF6 beta on endoplasmic reticulum stress response gene expression and cell viability. J Biol Chem 2007 Aug 3 3
27 17525289 Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells. Blood 2007 Oct 1 7
28 17624530 IPI-504, a novel and soluble HSP-90 inhibitor, blocks the unfolded protein response in multiple myeloma cells. Cancer Chemother Pharmacol 2008 May 1
29 17702888 Geranylgeranylacetone, an inducer of the 70-kDa heat shock protein (HSP70), elicits unfolded protein response and coordinates cellular fate independently of HSP70. Mol Pharmacol 2007 Nov 1
30 17941056 Ethanol promotes endoplasmic reticulum stress-induced neuronal death: involvement of oxidative stress. J Neurosci Res 2008 Mar 1
31 18022401 Coupling cystic fibrosis to endoplasmic reticulum stress: Differential role of Grp78 and ATF6. Biochim Biophys Acta 2007 Dec 6
32 18559892 Initiation and execution of lipotoxic ER stress in pancreatic beta-cells. J Cell Sci 2008 Jul 15 2
33 18635952 Mitotic regulation of SREBP and ATF6 by separation of the Golgi and ER. Cell Cycle 2008 Jul 15 1
34 18815184 Salvianolic acid B protects human endothelial cells from oxidative stress damage: a possible protective role of glucose-regulated protein 78 induction. Cardiovasc Res 2009 Jan 1 2
35 18989785 Involvement of endoplasmic reticulum stress in Docetaxel-induced JNK-dependent apoptosis of human melanoma. Apoptosis 2008 Dec 1
36 19176121 [Mechanism of arsenic trioxide induced apoptosis in cultured human lens epithelium cells]. Zhonghua Yan Ke Za Zhi 2008 Oct 1
37 19304306 The 8ab protein of SARS-CoV is a luminal ER membrane-associated protein and induces the activation of ATF6. Virology 2009 May 10 3
38 19420237 ATF6alpha induces XBP1-independent expansion of the endoplasmic reticulum. J Cell Sci 2009 May 15 3
39 19423713 Neuroserpin polymers activate NF-kappaB by a calcium signaling pathway that is independent of the unfolded protein response. J Biol Chem 2009 Jul 3 1
40 19667116 The ATF6-Met[67]Val substitution is associated with increased plasma cholesterol levels. Arterioscler Thromb Vasc Biol 2009 Sep 3
41 19671747 Induction of endoplasmic reticulum stress response by TZD18, a novel dual ligand for peroxisome proliferator-activated receptor alpha/gamma, in human breast cancer cells. Mol Cancer Ther 2009 Aug 1
42 19693772 N-glycosylation of ATF6beta is essential for its proteolytic cleavage and transcriptional repressor function to ATF6alpha. J Cell Biochem 2009 Nov 1 3
43 19715772 Glucolipotoxicity of the pancreatic beta cell. Biochim Biophys Acta 2010 Mar 1
44 19723703 Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways. FASEB J 2010 Jan 2
45 19822759 In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles. Proc Natl Acad Sci U S A 2009 Oct 20 1
46 19878647 Evidence that endoplasmic reticulum (ER) stress and caspase-4 activation occur in human neutrophils. Biochem Biophys Res Commun 2010 Jan 1 1
47 20003459 2-Deoxy-D-glucose enhances TRAIL-induced apoptosis in human melanoma cells through XBP-1-mediated up-regulation of TRAIL-R2. Mol Cancer 2009 Dec 14 3
48 20038265 Metformin regulates palmitate-induced apoptosis and ER stress response in HepG2 liver cells. Immunopharmacol Immunotoxicol 2010 Jun 1
49 20165829 Glucosamine-induced endoplasmic reticulum stress affects GLUT4 expression via activating transcription factor 6 in rat and human skeletal muscle cells. Diabetologia 2010 May 2
50 20554776 Coxsackievirus B3 infection activates the unfolded protein response and induces apoptosis through downregulation of p58IPK and activation of CHOP and SREBP1. J Virol 2010 Sep 1