CREB regulated transcription coactivator 1 ; Mus musculus






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1 16870609 Nutrient-dependent multimerization of the mammalian target of rapamycin through the N-terminal HEAT repeat region. J Biol Chem 2006 Sep 29 3
2 16936779 A novel mechanism for Bcr-Abl action: Bcr-Abl-mediated induction of the eIF4F translation initiation complex and mRNA translation. Oncogene 2007 Feb 22 1
3 17041621 Upstream of the mammalian target of rapamycin: do all roads pass through mTOR? Oncogene 2006 Oct 16 1
4 17052453 S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt. Mol Cell 2006 Oct 20 1
5 17234746 Evidence for a molecular link between the tuberous sclerosis complex and the Crumbs complex. Hum Mol Genet 2007 Mar 1 1
6 17334390 Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition. Oncogene 2007 Aug 16 2
7 17386266 PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell 2007 Mar 23 4
8 17407584 Rapamycin-induced inhibition of HTLV-I LTR activity is rescued by c-Myb. Retrovirology 2007 Apr 3 1
9 17517883 The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1. J Biol Chem 2007 Jul 13 2
10 17568186 Possible involvement of persistent activity of the mammalian target of rapamycin pathway in the cisplatin resistance of AFP-producing gastric cancer cells. Cancer Biol Ther 2007 Jul 5
11 17656678 Interferon-gamma induces human vascular smooth muscle cell proliferation and intimal expansion by phosphatidylinositol 3-kinase dependent mammalian target of rapamycin raptor complex 1 activation. Circ Res 2007 Sep 14 2
12 17724476 Regulation of cyclin D1 expression by mTORC1 signaling requires eukaryotic initiation factor 4E-binding protein 1. Oncogene 2008 Feb 14 1
13 17971516 TNF-alpha increases protein content in C2C12 and primary myotubes by enhancing protein translation via the TNF-R1, PI3K, and MEK. Am J Physiol Endocrinol Metab 2008 Feb 1
14 18025151 IL-2- and IL-15-induced activation of the rapamycin-sensitive mTORC1 pathway in malignant CD4+ T lymphocytes. Blood 2008 Feb 15 1
15 18056704 mTORC1 signaling can regulate growth factor activation of p44/42 mitogen-activated protein kinases through protein phosphatase 2A. J Biol Chem 2008 Feb 1 1
16 18070882 Rapid turnover of the mTOR complex 1 (mTORC1) repressor REDD1 and activation of mTORC1 signaling following inhibition of protein synthesis. J Biol Chem 2008 Feb 8 1
17 18215133 The binding of PRAS40 to 14-3-3 proteins is not required for activation of mTORC1 signalling by phorbol esters/ERK. Biochem J 2008 Apr 1 3
18 18235224 mTORC1 signaling requires proteasomal function and the involvement of CUL4-DDB1 ubiquitin E3 ligase. Cell Cycle 2008 Feb 1 1
19 18250144 In human endothelial cells rapamycin causes mTORC2 inhibition and impairs cell viability and function. Cardiovasc Res 2008 Jun 1 1
20 18303120 Mechanisms of high-glucose/insulin-mediated desensitization of acute insulin-stimulated glucose transport and Akt activation. Am J Physiol Endocrinol Metab 2008 May 2
21 18305408 Anti-cancer agent siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation. Autophagy 2008 May 1
22 18354181 Activation and function of the mTORC1 pathway in mast cells. J Immunol 2008 Apr 1 3
23 18372248 Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation. J Biol Chem 2008 Jun 6 4
24 18495876 Response of a neuronal model of tuberous sclerosis to mammalian target of rapamycin (mTOR) inhibitors: effects on mTORC1 and Akt signaling lead to improved survival and function. J Neurosci 2008 May 21 2
25 18497260 The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 2008 Jun 13 3
26 18511518 The tuberous sclerosis complex regulates trafficking of glucose transporters and glucose uptake. Am J Pathol 2008 Jun 1
27 18548104 PI-103, a dual inhibitor of Class IA phosphatidylinositide 3-kinase and mTOR, has antileukemic activity in AML. Leukemia 2008 Sep 1
28 18556237 Activation of the mammalian target of rapamycin complex 1 is both necessary and sufficient to stimulate eukaryotic initiation factor 2Bvarepsilon mRNA translation and protein synthesis. Int J Biochem Cell Biol 2008 1
29 18587048 Disruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner. Proc Natl Acad Sci U S A 2008 Jul 8 2
30 18614546 Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1. Hum Mol Genet 2008 Oct 1 1
31 18621930 Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation. Blood 2008 Sep 15 2
32 18638456 AMPK represses TOP mRNA translation but not global protein synthesis in liver. Biochem Biophys Res Commun 2008 Sep 19 1
33 18664580 mTORC1 promotes survival through translational control of Mcl-1. Proc Natl Acad Sci U S A 2008 Aug 5 1
34 18676370 Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling. J Biol Chem 2008 Nov 7 3
35 18682538 Leucine stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing mTORC1 activation. Am J Physiol Endocrinol Metab 2008 Oct 1
36 18701483 Effects of the dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor NVP-BEZ235 on the tumor vasculature: implications for clinical imaging. Cancer Res 2008 Aug 15 1
37 18708754 Everolimus (RAD001) and anti-angiogenic cyclophosphamide show long-term control of gastric cancer growth in vivo. Cancer Biol Ther 2008 Sep 2
38 18722121 Oncogenic MAPK signaling stimulates mTORC1 activity by promoting RSK-mediated raptor phosphorylation. Curr Biol 2008 Sep 9 1
39 18725988 Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J Clin Invest 2008 Sep 1
40 18762023 SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab 2008 Sep 2
41 18765678 Amino acid regulation of TOR complex 1. Am J Physiol Endocrinol Metab 2009 Apr 11
42 18768766 Rapamycin does not improve insulin sensitivity despite elevated mammalian target of rapamycin complex 1 activity in muscles of ob/ob mice. Am J Physiol Regul Integr Comp Physiol 2008 Nov 2
43 18768809 Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in ApcDelta716 mice. Proc Natl Acad Sci U S A 2008 Sep 9 1
44 18776140 Fatty acid synthase inhibitors modulate energy balance via mammalian target of rapamycin complex 1 signaling in the central nervous system. Diabetes 2008 Dec 2
45 18776922 Regulation of androgen receptor transcriptional activity by rapamycin in prostate cancer cell proliferation and survival. Oncogene 2008 Nov 27 2
46 18794886 The PTEN-PI3K pathway: of feedbacks and cross-talks. Oncogene 2008 Sep 18 1
47 18812319 Isolation of hyperactive mutants of mammalian target of rapamycin. J Biol Chem 2008 Nov 14 1
48 18832178 The splicing-factor oncoprotein SF2/ASF activates mTORC1. Proc Natl Acad Sci U S A 2008 Oct 7 1
49 18927511 mTOR signaling: PLD takes center stage. Cell Cycle 2008 Oct 3
50 18945681 Differential dependence of hypoxia-inducible factors 1 alpha and 2 alpha on mTORC1 and mTORC2. J Biol Chem 2008 Dec 12 1