ceramide synthase 2 ; Mus musculus






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1 17901973 Differential expression of (dihydro)ceramide synthases in mouse brain: oligodendrocyte-specific expression of CerS2/Lass2. Histochem Cell Biol 2008 Feb 2
2 18205190 Long-chain ceramide is elevated in presenilin 1 (PS1M146V) mouse brain and induces apoptosis in PS1 astrocytes. Glia 2008 Mar 2
3 19801672 Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas. J Biol Chem 2009 Nov 27 1
4 20110363 A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways. J Biol Chem 2010 Apr 2 3
5 21773940 Temporal expression profiles of ceramide and ceramide-related genes in wild-type and mPer1/mPer2 double knockout mice. Mol Biol Rep 2012 Apr 1
6 22911490 Ablation of very long acyl chain sphingolipids causes hepatic insulin resistance in mice due to altered detergent-resistant membranes. Hepatology 2013 Feb 2
7 23283968 Ablation of ceramide synthase 2 causes chronic oxidative stress due to disruption of the mitochondrial respiratory chain. J Biol Chem 2013 Feb 15 5
8 23591958 Cell-type-specific expression pattern of ceramide synthase 2 protein in mouse tissues. Histochem Cell Biol 2013 Nov 4
9 23690971 Ceramide synthases expression and role of ceramide synthase-2 in the lung: insight from human lung cells and mouse models. PLoS One 2013 9
10 24019516 Protection of a ceramide synthase 2 null mouse from drug-induced liver injury: role of gap junction dysfunction and connexin 32 mislocalization. J Biol Chem 2013 Oct 25 7
11 24263103 Altering the sphingolipid acyl chain composition prevents LPS/GLN-mediated hepatic failure in mice by disrupting TNFR1 internalization. Cell Death Dis 2013 Nov 21 1
12 24337404 Enhancement of DEN-induced liver tumourigenesis in hepatocyte-specific Lass2-knockout mice coincident with upregulation of the TGF-β1-Smad4-PAI-1 axis. Oncol Rep 2014 Feb 6
13 24842017 [LASS2/TMSG1 gene silencing promotes the invasiveness and metastatic of human prostatic carcinoma cells through increase in vacuolar ATPase activity]. Zhonghua Bing Li Xue Za Zhi 2014 Mar 2
14 25241943 Hepatic fatty acid uptake is regulated by the sphingolipid acyl chain length. Biochim Biophys Acta 2014 Dec 5
15 25333455 Knockout of the HCC suppressor gene Lass2 downregulates the expression level of miR-694. Oncol Rep 2014 Dec 2
16 25720061 Ceramide and sphingosine in pulmonary infections. Biol Chem 2015 Jun 4
17 26288989 Altering sphingolipid composition with aging induces contractile dysfunction of gastric smooth muscle via K(Ca) 1.1 upregulation. Aging Cell 2015 Dec 1
18 26734662 Quantified CSF antibody reactivity against myelin in multiple sclerosis. Ann Clin Transl Neurol 2015 Dec 2
19 26900161 Lactosylceramide contributes to mitochondrial dysfunction in diabetes. J Lipid Res 2016 Apr 1
20 27162368 Ectopic expression of ceramide synthase 2 in neurons suppresses neurodegeneration induced by ceramide synthase 1 deficiency. Proc Natl Acad Sci U S A 2016 May 24 2
21 27363720 KCa 3.1 upregulation preserves endothelium-dependent vasorelaxation during aging and oxidative stress. Aging Cell 2016 Oct 2
22 27591968 Regulation of glucose homeostasis and insulin action by ceramide acyl-chain length: A beneficial role for very long-chain sphingolipid species. Biochim Biophys Acta 2016 Nov 3
23 28198542 Ceramide synthase 2 facilitates S1P-dependent egress of thymocytes into the circulation in mice. Eur J Immunol 2017 Apr 2
24 28405720 Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity. Cell Mol Life Sci 2017 Aug 9
25 28699686 Ablation of ceramide synthase 2 exacerbates dextran sodium sulphate-induced colitis in mice due to increased intestinal permeability. J Cell Mol Med 2017 Dec 2
26 29127192 Lipotoxic very-long-chain ceramides cause mitochondrial dysfunction, oxidative stress, and cell death in cardiomyocytes. FASEB J 2018 Mar 4
27 29196503 Sphingolipid regulation of lung epithelial cell mitophagy and necroptosis during cigarette smoke exposure. FASEB J 2018 Apr 3
28 29626628 Hepatocyte-specific deletion of LASS2 protects against diet-induced hepatic steatosis and insulin resistance. Free Radic Biol Med 2018 May 20 1
29 29653252 Inactivation of ceramide synthase 2 catalytic activity in mice affects transcription of genes involved in lipid metabolism and cell division. Biochim Biophys Acta Mol Cell Biol Lipids 2018 Jul 5
30 30866987 Proteomics of the corpus callosum to identify novel factors involved in hypomyelinated Niemann-Pick Type C disease mice. Mol Brain 2019 Mar 11 2
31 31676768 Hepatic triglyceride accumulation via endoplasmic reticulum stress-induced SREBP-1 activation is regulated by ceramide synthases. Exp Mol Med 2019 Nov 1 3
32 31766565 In Human and Mouse Spino-Cerebellar Tissue, Ataxin-2 Expansion Affects Ceramide-Sphingomyelin Metabolism. Int J Mol Sci 2019 Nov 21 1
33 31916656 Sphingosine kinases protect murine embryonic stem cells from sphingosine-induced cell cycle arrest. Stem Cells 2020 May 3
34 32279995 LASS2 regulates hepatocyte steatosis by interacting with NDUFS2/OXPHOS related proteins. Biochem Biophys Res Commun 2020 Jun 11 3
35 33800208 Ceramide Synthase 2 Null Mice Are Protected from Ovalbumin-Induced Asthma with Higher T Cell Receptor Signal Strength in CD4+ T Cells. Int J Mol Sci 2021 Mar 8 4
36 35181339 Fatty acid transport protein 2 interacts with ceramide synthase 2 to promote ceramide synthesis. J Biol Chem 2022 Apr 1
37 35365625 Long-chain ceramides are cell non-autonomous signals linking lipotoxicity to endoplasmic reticulum stress in skeletal muscle. Nat Commun 2022 Apr 1 2