nucleotide binding oligomerization domain containing 2 ; Homo sapiens






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1 9797357 American families with Crohn's disease have strong evidence for linkage to chromosome 16 but not chromosome 12. Gastroenterology 1998 Nov 1
2 11113069 Linkage heterogeneity for the IBD1 locus in Crohn's disease pedigrees by disease onset and severity. Gastroenterology 2000 Dec 1
3 11385576 Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001 May 31 3
4 11385577 A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001 May 31 1
5 11826800 Biological and novel therapies for inflammatory bowel disease in children. Pediatr Clin North Am 2002 Feb 1
6 11910337 The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease. Gastroenterology 2002 Apr 1
7 12019468 CARD15 genetic variation in a Quebec population: prevalence, genotype-phenotype relationship, and haplotype structure. Am J Hum Genet 2002 Jul 1
8 12105836 Lack of common NOD2 variants in Japanese patients with Crohn's disease. Gastroenterology 2002 Jul 1
9 12512038 Crohn's disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan. Gastroenterology 2003 Jan 1
10 12514169 Host recognition of bacterial muramyl dipeptide mediated through NOD2. Implications for Crohn's disease. J Biol Chem 2003 Feb 21 10
11 12527755 Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J Biol Chem 2003 Mar 14 4
12 12540091 Electroadsorption of acilan blau dye from textile effluents by using activated carbon-perlite mixtures. Water Environ Res 2002 Nov-Dec 2
13 12671896 CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells. Gastroenterology 2003 Apr 2
14 12851870 Crohn's disease and the NOD2 gene: a role for paneth cells. Gastroenterology 2003 Jul 1
15 12871942 Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2. J Biol Chem 2003 Oct 24 3
16 12925128 Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation. Cell Microbiol 2003 Sep 2
17 15044951 Regulatory regions and critical residues of NOD2 involved in muramyl dipeptide recognition. EMBO J 2004 Apr 7 2
18 15075345 Reciprocal cross-talk between Nod2 and TAK1 signaling pathways. J Biol Chem 2004 Jun 11 1
19 15157827 Towards an understanding of the role of NOD2/CARD15 in the pathogenesis of Crohn's disease. Best Pract Res Clin Gastroenterol 2004 Jun 1
20 15168811 CARD15 mutation analysis in an Italian population: Leu1007fsinsC but neither Arg702Trp nor Gly908Arg mutations are associated with Crohn's disease. Inflamm Bowel Dis 2004 Mar 2
21 15198989 Regulation of IL-8 and IL-1beta expression in Crohn's disease associated NOD2/CARD15 mutations. Hum Mol Genet 2004 Aug 15 5
22 15202784 Detection of the Arg702Trp, Gly908Arg and Leu1007fsinsC polymorphisms of the NOD2/CARD15 gene by real-time PCR with melting curve analysis. Clin Chem Lab Med 2004 May 8
23 15330254 Nods and 'intracellular' innate immunity. C R Biol 2004 Jun 1
24 15521010 hPepT1 transports muramyl dipeptide, activating NF-kappaB and stimulating IL-8 secretion in human colonic Caco2/bbe cells. Gastroenterology 2004 Nov 4
25 15617523 Muramyldipeptide and diaminopimelic acid-containing desmuramylpeptides in combination with chemically synthesized Toll-like receptor agonists synergistically induced production of interleukin-8 in a NOD2- and NOD1-dependent manner, respectively, in human monocytic cells in culture. Cell Microbiol 2005 Jan 6
26 15637755 NOD2/CARD15 gene polymorphism in patients with inflammatory bowel disease: is Hungary different? World J Gastroenterol 2005 Jan 21 1
27 15638227 Acute intestinal obstruction and NOD2/CARD15 mutations among Italian Crohn's disease patients. Eur Rev Med Pharmacol Sci 2004 Sep-Oct 4
28 15701651 ASC-mediated NF-kappaB activation leading to interleukin-8 production requires caspase-8 and is inhibited by CLARP. J Biol Chem 2005 Apr 15 2
29 15753091 GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells. J Biol Chem 2005 May 13 1
30 15800781 Functional interaction of CARD15/NOD2 and Crohn's disease-associated TNFalpha polymorphisms. Int J Colorectal Dis 2005 Jul 1
31 15910952 Muramyl dipeptide and toll-like receptor sensitivity in NOD2-associated Crohn's disease. Lancet 2005 May 21-27 2
32 15928043 Synergy between TLR9 and NOD2 innate immune responses is lost in genetic Crohn's disease. Gut 2005 Nov 1
33 15955786 Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn's disease. Gut 2005 Oct 1
34 15990626 Influence of CARD15 mutations on disease activity and response to therapy in 65 pediatric Crohn patients from Saxony, Germany. J Pediatr Gastroenterol Nutr 2005 Jul 2
35 15998797 Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition. J Cell Biol 2005 Jul 4 4
36 15999810 Genomic mining of new genes and pathways in innate and adaptive immunity. Novartis Found Symp 2005 1
37 16021602 Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists. Eur J Immunol 2005 Aug 4
38 16052966 [Epidemiology and risk factors of inflammatory bowel diseases]. Rev Prat 2005 May 15 2
39 16107869 Current status of genetics research in inflammatory bowel disease. Genes Immun 2005 Dec 2
40 16115863 The frameshift mutation in Nod2 results in unresponsiveness not only to Nod2- but also Nod1-activating peptidoglycan agonists. J Biol Chem 2005 Oct 28 3
41 16126943 Crohn's disease is associated with polymorphism of CARD15/NOD2 gene in a Hungarian population. Ann N Y Acad Sci 2005 Jun 4
42 16133971 The relation between NOD2/CARD15 mutations and the prevalence and phenotypic heterogeneity of Crohn's disease: lessons from the Israeli Arab Crohn's disease cohort. Dig Dis Sci 2005 Sep 2
43 16134725 Analysis of CARD15/NOD2 haplotypes fails to identify common variants associated with rheumatoid arthritis susceptibility. Scand J Rheumatol 2005 May-Jun 2
44 16190851 The isolated perfused kidney: an in vitro test system for evaluation of renal tissue damage induced by high-energy shockwaves sources. J Endourol 2005 Sep 1
45 16222728 Synthesis and proinflammatory properties of muramyl tripeptides containing lysine and diaminopimelic acid moieties. Chembiochem 2005 Nov 1
46 16239840 Genotype-phenotype analysis in childhood-onset Crohn's disease: NOD2/CARD15 variants consistently predict phenotypic characteristics of severe disease. Inflamm Bowel Dis 2005 Nov 8
47 16257953 Analysis of NOD2-mediated proteome response to muramyl dipeptide in HEK293 cells. J Biol Chem 2006 Jan 27 3
48 16260731 IL-32 synergizes with nucleotide oligomerization domain (NOD) 1 and NOD2 ligands for IL-1beta and IL-6 production through a caspase 1-dependent mechanism. Proc Natl Acad Sci U S A 2005 Nov 8 3
49 16288731 Induction and localization of NOD2 protein in human endothelial cells. Cell Immunol 2005 Sep 2
50 16319062 NOD2/CARD15 mediates induction of the antimicrobial peptide human beta-defensin-2. J Biol Chem 2006 Jan 27 5