X-ray repair cross complementing 6 ; Homo sapiens






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1 315289 Further characterization of a human T lymphocyte associated antigen. Clin Exp Immunol 1979 Aug 4
2 10026262 DNA-dependent protein kinase phosphorylation sites in Ku 70/80 heterodimer. Biochemistry 1999 Feb 9 4
3 10075997 The repressor which binds the -75 GATA motif of the GPB promoter contains Ku70 as the DNA binding subunit. Nucleic Acids Res 1999 Apr 1 1
4 10413594 The nuclear localization signal of the human Ku70 is a variant bipartite type recognized by the two components of nuclear pore-targeting complex. Exp Cell Res 1999 Aug 1 2
5 11112693 Nuclear localization of Ku antigen is promoted independently by basic motifs in the Ku70 and Ku80 subunits. J Cell Sci 2001 Jan 1
6 11112778 Human Ku70 interacts with heterochromatin protein 1alpha. J Biol Chem 2001 Mar 16 2
7 11175667 Hypertonic treatment inhibits radiation-induced nuclear translocation of the Ku proteins G22p1 (Ku70) and Xrcc5 (Ku80) in rat fibroblasts. Radiat Res 2001 Feb 1
8 11376007 Protein phosphatases regulate DNA-dependent protein kinase activity. J Biol Chem 2001 Jun 1 2
9 11925933 Analysis of gene expression profiles associated with cisplatin resistance in human ovarian cancer cell lines and tissues using cDNA microarray. Hum Cell 2001 Dec 2
10 12124328 Deficient nonhomologous end-joining activity in cell-free extracts from Brca1-null fibroblasts. Cancer Res 2002 Jul 15 2
11 12324457 Expression of Ku70 and Ku80 mediated by NF-kappa B and cyclooxygenase-2 is related to proliferation of human gastric cancer cells. J Biol Chem 2002 Nov 29 1
12 12481432 Efficacy of a glutathione S-transferase pi-activated prodrug in platinum-resistant ovarian cancer cells. Mol Cancer Ther 2002 Oct 1
13 12509248 Suppression of a DNA double-strand break repair gene, Ku70, increases radio- and chemosensitivity in a human lung carcinoma cell line. DNA Repair (Amst) 2002 Apr 29 2
14 12551933 Synthesis and functional analyses of nuclear clusterin, a cell death protein. J Biol Chem 2003 Mar 28 1
15 12702565 Increased error-prone NHEJ activity in myeloid leukemias is associated with DNA damage at sites that recruit key nonhomologous end-joining proteins. Cancer Res 2003 Apr 15 1
16 14734561 Identification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1. J Biol Chem 2004 Apr 2 2
17 14991539 Application of new in situ hybridization probes for Ku70 and Ku80 in tissue microarrays of paraffin-embedded malignant melanomas: correlation with immunohistochemical analysis. Hum Pathol 2004 Feb 1
18 15023334 Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Mol Cell 2004 Mar 12 1
19 15205359 Ectopic expression of Bcl-XL or Ku70 protects human colon cancer cells (SW480) against curcumin-induced apoptosis while their down-regulation potentiates it. Carcinogenesis 2004 Oct 4
20 15551138 Down-regulation of Ku 70 and Ku 80 mRNA expression in transitional cell carcinomas of the urinary bladder related to tumor progression. World J Urol 2004 Dec 1
21 15613478 Actinomycin D induces histone gamma-H2AX foci and complex formation of gamma-H2AX with Ku70 and nuclear DNA helicase II. J Biol Chem 2005 Mar 11 1
22 15827325 Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and gamma radiation. Mol Cancer Ther 2005 Apr 3
23 15905197 Justicidin A decreases the level of cytosolic Ku70 leading to apoptosis in human colorectal cancer cells. Carcinogenesis 2005 Oct 3
24 15941674 DNA-PK-dependent phosphorylation of Ku70/80 is not required for non-homologous end joining. DNA Repair (Amst) 2005 Aug 15 5
25 16000590 Histone deacetylase inhibitors radiosensitize human melanoma cells by suppressing DNA repair activity. Clin Cancer Res 2005 Jul 1 1
26 16168844 Inhibition of DNA repair as a mechanism of enhanced radioresponse of head and neck carcinoma cells by a selective cyclooxygenase-2 inhibitor, celecoxib. Int J Radiat Oncol Biol Phys 2005 Oct 1 1
27 16360032 Ku70, a component of DNA-dependent protein kinase, is a mammalian receptor for Rickettsia conorii. Cell 2005 Dec 16 2
28 16368436 Involvement of the ubiquitin pathway in decreasing Ku70 levels in response to drug-induced apoptosis. Exp Cell Res 2006 Feb 15 1
29 16440001 Granzyme A, which causes single-stranded DNA damage, targets the double-strand break repair protein Ku70. EMBO Rep 2006 Apr 2
30 16531993 Evidence for the existence of an HP1-mediated subcode within the histone code. Nat Cell Biol 2006 Apr 1
31 16928817 Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci. Mol Cancer Ther 2006 Aug 2
32 17071631 Securin induces genetic instability in colorectal cancer by inhibiting double-stranded DNA repair activity. Carcinogenesis 2007 Mar 1
33 17124166 Dynamic assembly of end-joining complexes requires interaction between Ku70/80 and XRCC4. Proc Natl Acad Sci U S A 2006 Dec 5 1
34 17223257 Camptothecin acts synergistically with imatinib and overcomes imatinib resistance through Bcr-Abl independence in human K562 cells. Cancer Lett 2007 Jul 8 1
35 17272272 Ku70/80 modulates ATM and ATR signaling pathways in response to DNA double strand breaks. J Biol Chem 2007 Apr 6 1
36 17283121 Ku70 and poly(ADP-ribose) polymerase-1 competitively regulate beta-catenin and T-cell factor-4-mediated gene transactivation: possible linkage of DNA damage recognition and Wnt signaling. Cancer Res 2007 Feb 1 1
37 17479409 Arsenite-induced alterations in Ku70-deficient cells: a model to study genotoxic effects. J Toxicol Environ Health A 2007 Jun 1
38 17534116 Modulation of Ku70/80, clusterin/ApoJ isoforms and Bax expression in indocyanine-green-mediated photo-oxidative cell damage. Ophthalmic Res 2007 1
39 17545612 Histone deacetylase inhibitors sensitize prostate cancer cells to agents that produce DNA double-strand breaks by targeting Ku70 acetylation. Cancer Res 2007 Jun 1 12
40 17569822 Bcr-Abl-independent imatinib-resistant K562 cells show aberrant protein acetylation and increased sensitivity to histone deacetylase inhibitors. J Pharmacol Exp Ther 2007 Sep 3
41 17596214 Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factors. J Neurochem 2007 Jul 1
42 17603632 CREB-binding protein is a mediator of neuroblastoma cell death induced by the histone deacetylase inhibitor trichostatin A. Neoplasia 2007 Jun 3
43 17617666 Nerve growth factor receptor TrkA signaling in breast cancer cells involves Ku70 to prevent apoptosis. Mol Cell Proteomics 2007 Nov 2
44 17642065 An increase in DNA double-strand breaks, induced by Ku70 depletion, is associated with human papillomavirus 16 episome loss and de novo viral integration events. J Pathol 2007 Sep 1
45 17885668 Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation. Cell Death Differ 2007 Dec 1
46 18164703 Accumulation of Ku80 proteins at DNA double-strand breaks in living cells. Exp Cell Res 2008 Mar 10 1
47 18355052 DNA-dependent conformational changes in the Ku heterodimer. Biochemistry 2008 Apr 15 1
48 18415044 Activities of DNA-PK and Ku86, but not Ku70, may predict sensitivity to cisplatin in human gliomas. J Neurooncol 2008 Aug 2
49 18546291 Ku70 predicts response and primary tumor recurrence after therapy in locally advanced head and neck cancer. Int J Cancer 2008 Sep 1 3
50 18710952 The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells. Mol Cell Biol 2008 Oct 1