rabaptin, RAB GTPase binding effector protein 2 ; Homo sapiens






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1 7513252 Differential regulation of folate receptor isoforms in normal and malignant tissues in vivo and in established cell lines. Physiologic and clinical implications. Cancer 1994 May 1 2
2 8061055 Selective expression of the high-affinity isoform of the folate receptor (FR-alpha) in the human placental syncytiotrophoblast and choriocarcinoma cells. Biochim Biophys Acta 1994 Aug 11 1
3 8110752 Identification of a novel folate receptor, a truncated receptor, and receptor type beta in hematopoietic cells: cDNA cloning, expression, immunoreactivity, and tissue specificity. Biochemistry 1994 Feb 8 1
4 8958184 Biochemistry and pharmacology of glycinamide ribonucleotide formyltransferase inhibitors: LY309887 and lometrexol. Invest New Drugs 1996 2
5 9166787 Identification of amino acid residues that determine the differential ligand specificities of folate receptors alpha and beta. Biochemistry 1997 May 20 9
6 9398177 Proteolysis of the carboxyl-terminal GPI signal independent of GPI modification as a mechanism for selective protein secretion. Biochemistry 1997 Nov 25 2
7 9426700 Role of folate receptor and reduced folate carrier in the transport of 5-methyltetrahydrofolic acid in human ovarian carcinoma cells. Int J Cancer 1998 Jan 5 5
8 9524116 Two distinct effectors of the small GTPase Rab5 cooperate in endocytic membrane fusion. EMBO J 1998 Apr 1 3
9 9545095 Lack of association between mutations in the folate receptor-alpha gene and spina bifida. Am J Med Genet 1998 Apr 1 3
10 9581553 Expression levels of functional folate receptors alpha and beta are related to the number of N-glycosylated sites. Biochem J 1997 Nov 1 2
11 10064698 Recognition of the carboxyl-terminal signal for GPI modification requires translocation of its hydrophobic domain across the ER membrane. J Mol Biol 1999 Mar 12 2
12 12095688 The half-life of the transcript encoding the folate receptor alpha in KB cells is reduced by cytosolic proteins expressed in folate-replete and not in folate-depleted cells. Gene 2002 May 29 6
13 12202950 Evidence for segregation of heterologous GPI-anchored proteins into separate lipid rafts within the plasma membrane. J Membr Biol 2002 Sep 1 1
14 15899836 Enhancement of folate receptor alpha expression in tumor cells through the glucocorticoid receptor: a promising means to improved tumor detection and targeting. Cancer Res 2005 May 15 5
15 17473184 The folate receptor alpha is frequently overexpressed in osteosarcoma samples and plays a role in the uptake of the physiologic substrate 5-methyltetrahydrofolate. Clin Cancer Res 2007 May 1 5
16 17979543 A novel monoclonal antibody for detection of folate receptor alpha in paraffin-embedded tissues. Hybridoma (Larchmt) 2007 Oct 6
17 18222534 Folate receptor alpha as a tumor target in epithelial ovarian cancer. Gynecol Oncol 2008 Mar 1
18 21542550 <sup>99m</sup>Tc-Labeled acetylated dendrimer poly(amido)-amine generation 5-folic acid-2-(<i>p</i>-isothiocyanatobenzyl)-6-methyl-diethylenetriamine pentaacetic acid conjugate 2004 1
19 21542551 <sup>99m</sup>Tc-Labeled acetylated dendrimer poly(amido)-amine generation 5-PEGylated folic acid-2-(<i>p</i>-isothiocyanatobenzyl)-6-methyl-diethylenetriamine pentaacetic acid conjugate 2004 1
20 21542552 Gadolinium-tetraazacyclododecane tetraacetic acid coupled with folate <i>via</i> bis(aminoethyl)ethylene glycol linker 2004 4
21 21647742 The effect of chemotherapy on expression of folate receptor-alpha in ovarian cancer. Cell Oncol (Dordr) 2012 Feb 1
22 23819524 Comparative analysis of folate derived PET imaging agents with [(18)F]-2-fluoro-2-deoxy-d-glucose using a rodent inflammatory paw model. Mol Pharm 2013 Aug 5 1
23 23851396 Structural basis for molecular recognition of folic acid by folate receptors. Nature 2013 Aug 22 7
24 23880302 Structural and functional insights on folate receptor α (FRα) by homology modeling, ligand docking and molecular dynamics. J Mol Graph Model 2013 Jul 7
25 24446917 Effect of receptor occupancy on folate receptor internalization. Mol Pharm 2014 Mar 3 1
26 24646866 Involvement of autophagy in antitumor activity of folate-appended methyl-β-cyclodextrin. Sci Rep 2014 Mar 20 1
27 26090596 Production of a High-affinity Monoclonal Antibody Reactive with Folate Receptors Alpha and Beta. Monoclon Antib Immunodiagn Immunother 2015 Jun 1
28 27221054 Albumin-Folate Conjugates for Drug-targeting in Photodynamic Therapy. Photochem Photobiol 2016 Jul 2
29 28110184 Structural analysis of binding functionality of folic acid-PEG dendrimers against folate receptor. J Mol Graph Model 2017 Mar 1
30 29129656 Enhancing tumor response to targeted chemotherapy through up-regulation of folate receptor α expression induced by dexamethasone and valproic acid. J Control Release 2018 Jan 10 4
31 29435118 Assessment of folate receptor alpha and beta expression in selection of lung and pancreatic cancer patients for receptor targeted therapies. Oncotarget 2018 Jan 12 2
32 29486262 Dual targeting system by supramolecular complex of folate-conjugated methyl-β-cyclodextrin with adamantane-grafted hyaluronic acid for the treatment of colorectal cancer. Int J Biol Macromol 2018 Jul 1 2
33 29616859 Expression of functional folate receptors in multiple myeloma. Leuk Lymphoma 2018 Dec 2
34 29654824 Escherichia coli expression, purification, and refolding of human folate receptor α (hFRα) and β (hFRβ). Protein Expr Purif 2018 Sep 1
35 29737910 In Vitro and In Vivo evaluation of a novel folate-targeted theranostic nanoemulsion of docetaxel for imaging and improved anticancer activity against ovarian cancers. Cancer Biol Ther 2018 Jul 3 1
36 30093227 Safety and activity findings from a phase 1b escalation study of mirvetuximab soravtansine, a folate receptor alpha (FRα)-targeting antibody-drug conjugate (ADC), in combination with carboplatin in patients with platinum-sensitive ovarian cancer. Gynecol Oncol 2018 Oct 1
37 30531606 Antibody-drug conjugates for ovarian cancer: current clinical development. Curr Opin Obstet Gynecol 2019 Feb 2
38 30668349 Augmented cytotoxic effects of paclitaxel by curcumin induced overexpression of folate receptor-α for enhanced targeted drug delivery in HeLa cells. Phytomedicine 2019 Mar 15 3
39 31926453 Decreased placental folate transporter expression and activity in first and second trimester in obese mothers. J Nutr Biochem 2020 Mar 2
40 32545327 Pharmacokinetic Properties of <sup>68</sup>Ga-labelled Folic Acid Conjugates: Improvement Using HEHE Tag. Molecules 2020 Jun 11 2
41 32618744 Novel antibody-drug conjugates: current and future roles in gynecologic oncology. Curr Opin Obstet Gynecol 2021 Feb 1 1
42 32659629 Type and size effect of functional groups on the novel antifolate target recognition folate receptors α and β: Docking, molecular dynamics and MM/PBSA study. J Mol Graph Model 2020 Nov 2
43 32919191 Folate and macrophage folate receptor-β in idiopathic pulmonary fibrosis disease: the potential therapeutic target? Biomed Pharmacother 2020 Nov 1
44 33203700 Folate Receptor Beta Designates Immunosuppressive Tumor-Associated Myeloid Cells That Can Be Reprogrammed with Folate-Targeted Drugs. Cancer Res 2021 Feb 1 2
45 33321157 pH-sensitive multi-drug liposomes targeting folate receptor β for efficient treatment of non-small cell lung cancer. J Control Release 2021 Feb 10 2
46 33321629 Efficient tumor-targeting delivery of siRNA via folate-receptor mediated biomimetic albumin nanoparticles enhanced by all-trans retinoic acid. Mater Sci Eng C Mater Biol Appl 2021 Feb 3
47 33670773 Heterocyclic Substitutions Greatly Improve Affinity and Stability of Folic Acid towards FRα. an In Silico Insight. Molecules 2021 Feb 18 3
48 35185910 Folate Receptor Beta for Macrophage Imaging in Rheumatoid Arthritis. Front Immunol 2022 1
49 35255727 Folate Receptor Expression by Human Monocyte-Derived Macrophage Subtypes and Effects of Corticosteroids. Cartilage 2022 Jan-Mar 3