sphingosine kinase 2 ; Homo sapiens






197 Article(s)
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1 6549003 Isolation and structure of a new antibiotic, indolizomycin, produced by a strain SK2-52 obtained by interspecies fusion treatment. J Antibiot (Tokyo) 1984 Nov 1
2 9140729 Humanization of an anti-human IL-6 mouse monoclonal antibody glycosylated in its heavy chain variable region. Hum Antibodies Hybridomas 1996 2
3 10220287 Prolongation of the effective duration of cytomedical therapy by re-injecting SK2 hybridoma cells microencapsulated within alginate-poly(L)lysine-alginate membranes into human interleukin-6 transgenic mice. Biol Pharm Bull 1999 Mar 1
4 10751414 Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform. J Biol Chem 2000 Jun 30 5
5 12163105 Modulation of recombinant and native neuronal SK channels by the neuroprotective drug riluzole. Eur J Pharmacol 2002 Aug 2 2
6 12734181 Small conductance Ca2+-activated K+ channels and calmodulin: cell surface expression and gating. J Biol Chem 2003 Jul 11 2
7 12772853 Effect of repeated ketoprofen administration during surgical castration of bulls on cortisol, immunological function, feed intake, growth, and behavior. J Anim Sci 2003 May 1
8 12835323 Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis. J Biol Chem 2003 Oct 10 3
9 13129923 Phosphorylation of the immunomodulatory drug FTY720 by sphingosine kinases. J Biol Chem 2003 Nov 28 1
10 14596938 The immunosuppressant FTY720 is phosphorylated by sphingosine kinase type 2. FEBS Lett 2003 Nov 6 2
11 14657188 Cloning and expression of a small-conductance Ca(2+)-activated K+ channel from the mouse cochlea: coexpression with alpha9/alpha10 acetylcholine receptors. J Neurophysiol 2004 Apr 4
12 15175384 A novel mechanism for the facilitation of theta-induced long-term potentiation by brain-derived neurotrophic factor. J Neurosci 2004 Jun 2 1
13 15848761 Synthesis and evaluation of sphingoid analogs as inhibitors of sphingosine kinases. Bioorg Med Chem 2005 May 16 4
14 15951439 Role of sphingosine kinase 2 in cell migration toward epidermal growth factor. J Biol Chem 2005 Aug 19 2
15 16118219 SphK1 and SphK2, sphingosine kinase isoenzymes with opposing functions in sphingolipid metabolism. J Biol Chem 2005 Nov 4 12
16 16690965 Apoptotic cells promote macrophage survival by releasing the antiapoptotic mediator sphingosine-1-phosphate. Blood 2006 Sep 1 1
17 17027903 Comparative quantification of sphingolipids and analogs in biological samples by high-performance liquid chromatography after chloroform extraction. Anal Biochem 2006 Nov 15 1
18 17311928 Sphingosine kinase type 2 activation by ERK-mediated phosphorylation. J Biol Chem 2007 Apr 20 3
19 17346996 The sphingosine kinase-sphingosine-1-phosphate axis is a determinant of mast cell function and anaphylaxis. Immunity 2007 Mar 2
20 17400555 Essential requirement for sphingosine kinase 2 in a sphingolipid apoptosis pathway activated by FTY720 analogues. J Biol Chem 2007 May 25 7
21 17555747 FTY720-phosphate is dephosphorylated by lipid phosphate phosphatase 3. FEBS Lett 2007 Jun 26 2
22 17623044 Distribution of sphingosine kinase activity and mRNA in rodent brain. J Neurochem 2007 Oct 1
23 17635916 Protein kinase D-mediated phosphorylation and nuclear export of sphingosine kinase 2. J Biol Chem 2007 Sep 14 5
24 17699106 (Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1. Mol Cancer Res 2007 Aug 1
25 17895250 Recycling of sphingosine is regulated by the concerted actions of sphingosine-1-phosphate phosphohydrolase 1 and sphingosine kinase 2. J Biol Chem 2007 Nov 23 2
26 17947634 Cutting edge: Modulation of intestinal autoimmunity and IL-2 signaling by sphingosine kinase 2 independent of sphingosine 1-phosphate. J Immunol 2007 Nov 1 1
27 17974990 Involvement of sphingosine kinase 2 in p53-independent induction of p21 by the chemotherapeutic drug doxorubicin. Cancer Res 2007 Nov 1 9
28 18485923 Regulation and functions of sphingosine kinases in the brain. Biochim Biophys Acta 2008 Sep 2
29 18511810 A selective sphingosine kinase 1 inhibitor integrates multiple molecular therapeutic targets in human leukemia. Blood 2008 Aug 15 3
30 18848895 SK2 channels are required for function and long-term survival of efferent synapses on mammalian outer hair cells. Mol Cell Neurosci 2009 Jan 4
31 19070545 Targeting sphingosine-1-phosphate signalling for cardioprotection. Curr Opin Pharmacol 2009 Apr 3
32 19168031 A lipid binding domain in sphingosine kinase 2. Biochem Biophys Res Commun 2009 Feb 27 4
33 19168577 Differential regulation of sphingosine kinases 1 and 2 in lung injury. Am J Physiol Lung Cell Mol Physiol 2009 Apr 1
34 19204724 SK2 potassium channel overexpression in basolateral amygdala reduces anxiety, stress-induced corticosterone secretion and dendritic arborization. Mol Psychiatry 2009 Sep 2
35 19211033 The sphingosine 1-phosphate receptor 5 and sphingosine kinases 1 and 2 are localised in centrosomes: possible role in regulating cell division. Cell Signal 2009 May 2
36 19240026 Sphingosine kinase isoforms regulate oxaliplatin sensitivity of human colon cancer cells through ceramide accumulation and Akt activation. J Biol Chem 2009 Apr 17 4
37 19479838 Synthesis of 7-aza- and 7-thiasphingosines, and evaluation of their interaction with sphingosine kinases and with T-cells. Chem Biodivers 2009 May 2
38 19490468 Expression of sphingosine kinase 2 in synovial fibroblasts of rheumatoid arthritis contributing to apoptosis by a sphingosine analogue, FTY720. Pathol Int 2009 Jun 4
39 19632123 Synthesis and biological evaluation of sphingosine kinase substrates as sphingosine-1-phosphate receptor prodrugs. Bioorg Med Chem 2009 Aug 15 1
40 20110355 Estradiol induces export of sphingosine 1-phosphate from breast cancer cells via ABCC1 and ABCG2. J Biol Chem 2010 Apr 2 3
41 20156522 Sphingosine kinase: Role in regulation of bioactive sphingolipid mediators in inflammation. Biochimie 2010 Jun 1
42 20179157 A novel sphingosine kinase inhibitor induces autophagy in tumor cells. J Pharmacol Exp Ther 2010 May 5
43 20188554 Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs. Bioorg Med Chem Lett 2010 Apr 1 1
44 20473784 Combined anticancer effects of sphingosine kinase inhibitors and sorafenib. Invest New Drugs 2011 Dec 3
45 20579378 EGFR isoforms and gene regulation in human endometrial cancer cells. Mol Cancer 2010 Jun 25 1
46 20610734 Elimination of a hydroxyl group in FTY720 dramatically improves the phosphorylation rate. Mol Pharmacol 2010 Oct 6
47 21307639 Targeting NFĸB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2. Cancer Biol Ther 2011 Apr 1 3
48 21519925 Non-phosphorylated FTY720 induces apoptosis of human microglia by activating SREBP2. Cell Mol Neurobiol 2011 Oct 3
49 21537471 Role of sphingosine kinase localization in sphingolipid signaling. World J Biol Chem 2010 Dec 26 1
50 21546914 The outs and the ins of sphingosine-1-phosphate in immunity. Nat Rev Immunol 2011 Jun 2