| 1 | 7822316 | Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. | J Biol Chem | 1995 Jan 13 |
2 |
| 2 | 10334873 | Ethanol potentiates the mitogenic effects of sphingosine 1-phosphate by a zinc- and calcium-dependent mechanism in fibroblasts. | Arch Biochem Biophys | 1999 Jun 1 |
3 |
| 3 | 10851233 | Extracellular zinc activates p70 S6 kinase through the phosphatidylinositol 3-kinase signaling pathway. | J Biol Chem | 2000 Aug 25 |
6 |
| 4 | 11577586 | [mTOR and FTY 720 inhibitors]. | Presse Med | 2001 Sep 1 |
3 |
| 5 | 11707573 | FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse. | Proc Natl Acad Sci U S A | 2001 Nov 20 |
1 |
| 6 | 11784055 | Exogenous amino acids regulate trophectoderm differentiation in the mouse blastocyst through an mTOR-dependent pathway. | Dev Biol | 2001 Dec 1 |
5 |
| 7 | 11875047 | A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. | Hum Mol Genet | 2002 Mar 1 |
1 |
| 8 | 12668503 | Rapamycin attenuates load-induced cardiac hypertrophy in mice. | Circulation | 2003 Apr 1 |
1 |
| 9 | 12801981 | Amino acid transport regulates blastocyst implantation. | Biol Reprod | 2003 Oct |
3 |
| 10 | 14534328 | mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo. | Proc Natl Acad Sci U S A | 2003 Oct 28 |
1 |
| 11 | 14559816 | The PCPH oncoprotein antagonizes the proapoptotic role of the mammalian target of rapamycin in the response of normal fibroblasts to ionizing radiation. | Cancer Res | 2003 Oct 1 |
3 |
| 12 | 14561707 | Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR. | J Clin Invest | 2003 Oct |
1 |
| 13 | 14579029 | MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632. | Diabetologia | 2003 Nov |
5 |
| 14 | 14612424 | mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF. | Mol Cell Biol | 2003 Dec |
2 |
| 15 | 14623899 | Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling. | J Biol Chem | 2004 Jan 30 |
3 |
| 16 | 14625550 | Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. | Nat Genet | 2003 Dec |
2 |
| 17 | 14634209 | Frap, FKBP12 rapamycin-associated protein, is a candidate gene for the plasmacytoma resistance locus Pctr2 and can act as a tumor suppressor gene. | Proc Natl Acad Sci U S A | 2003 Dec 9 |
1 |
| 18 | 14970221 | Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status. | J Biol Chem | 2004 Apr 16 |
1 |
| 19 | 14976243 | Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs. | Proc Natl Acad Sci U S A | 2004 Mar 2 |
1 |
| 20 | 15010863 | IL2-dependent phosphorylation of 40S ribosomal protein S6 is controlled by PI-3K/mTOR signalling in CTLL2 cells. | Int J Mol Med | 2004 Apr |
2 |
| 21 | 15017384 | Osteoclast formation, survival and morphology are highly dependent on exogenous cholesterol/lipoproteins. | Cell Death Differ | 2004 Jul |
1 |
| 22 | 15029198 | Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. | Nature | 2004 Mar 18 |
1 |
| 23 | 15184287 | Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload. | Circulation | 2004 Jun 22 |
1 |
| 24 | 15199413 | Stable expression of small interfering RNA sensitizes TEL-PDGFbetaR to inhibition with imatinib or rapamycin. | J Clin Invest | 2004 Jun |
1 |
| 25 | 15286700 | Prolactin induces c-Myc expression and cell survival through activation of Src/Akt pathway in lymphoid cells. | Oncogene | 2004 Sep 23 |
1 |
| 26 | 15338249 | Lyophilized carrot ingestion lowers lipemia and beneficially affects cholesterol metabolism in cholesterol-fed C57BL/6J mice. | Eur J Nutr | 2004 Aug |
1 |
| 27 | 15479767 | Amino acids and leucine allow insulin activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice. | FASEB J | 2004 Dec |
2 |
| 28 | 15485918 | Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. | Mol Cell Biol | 2004 Nov |
1 |
| 29 | 15608593 | Microarray analysis of ethanol-treated cortical neurons reveals disruption of genes related to the ubiquitin-proteasome pathway and protein synthesis. | Alcohol Clin Exp Res | 2004 Dec |
1 |
| 30 | 15625701 | Mouse embryonic stem cells and preimplantation embryos require signaling through the phosphatidylinositol 3-kinase pathway to suppress apoptosis. | Mol Reprod Dev | 2005 Mar |
1 |
| 31 | 15705789 | Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival. | Blood | 2005 Jun 1 |
1 |
| 32 | 15767444 | Roles of the Ras-MEK-mitogen-activated protein kinase and phosphatidylinositol 3-kinase-Akt-mTOR pathways in Jaagsiekte sheep retrovirus-induced transformation of rodent fibroblast and epithelial cell lines. | J Virol | 2005 Apr |
2 |
| 33 | 15781267 | Suppression of PI3K/mTOR pathway rescues LLC cells from cell death induced by hypoxia. | Biochem Biophys Res Commun | 2005 Apr 29 |
2 |
| 34 | 15781656 | Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma. | Cancer Res | 2005 Mar 15 |
1 |
| 35 | 15833854 | Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras. | Cancer Res | 2005 Apr 15 |
2 |
| 36 | 15846106 | PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors. | Cancer Biol Ther | 2005 May |
1 |
| 37 | 15897901 | Regulation of the phosphorylation and integrity of protein synthesis initiation factor eIF4GI and the translational repressor 4E-BP1 by p53. | Oncogene | 2005 Jul 14 |
1 |
| 38 | 15940265 | Enhanced radiation damage of tumor vasculature by mTOR inhibitors. | Oncogene | 2005 Aug 18 |
1 |
| 39 | 16014032 | Gas6 induces Akt/mTOR-mediated mesangial hypertrophy in diabetic nephropathy. | Kidney Int | 2005 Aug |
2 |
| 40 | 16086373 | Role of PI3K/Akt signaling in insulin-like growth factor-1 (IGF-1) skin tumor promotion. | Mol Carcinog | 2005 Oct |
1 |
| 41 | 16333141 | Targeting the signaling pathway of acylation stimulating protein. | J Lipid Res | 2006 Mar |
1 |
| 42 | 16341243 | Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. | Nat Med | 2006 Jan |
1 |
| 43 | 16364254 | Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic mice. | Biochem Biophys Res Commun | 2006 Feb 3 |
2 |
| 44 | 16396989 | Differential mitogenic signaling in insulin receptor-deficient fetal pancreatic beta-cells. | Endocrinology | 2006 Apr |
4 |
| 45 | 16413820 | Anti-genotoxic effect of Aloysia triphylla infusion against acrylamide-induced DNA damage as shown by the comet assay technique. | Mutat Res | 2006 Feb 28 |
1 |
| 46 | 16424025 | Effect of rapamycin on mouse chronic lymphocytic leukemia and the development of nonhematopoietic malignancies in Emu-TCL1 transgenic mice. | Cancer Res | 2006 Jan 15 |
1 |
| 47 | 16567633 | The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. | Proc Natl Acad Sci U S A | 2006 Apr 4 |
1 |
| 48 | 16598206 | Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. | Nature | 2006 May 25 |
1 |
| 49 | 16613881 | Activation of the mTOR signalling pathway is required for pancreatic growth in protease-inhibitor-fed mice. | J Physiol | 2006 Jun 15 |
1 |
| 50 | 16652094 | Everolimus (RAD) inhibits in vivo growth of murine squamous cell carcinoma (SCC VII). | Laryngoscope | 2006 May |
2 |