mechanistic target of rapamycin kinase ; Mus musculus






2257 Article(s)
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1 7822316 Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J Biol Chem 1995 Jan 13 2
2 10334873 Ethanol potentiates the mitogenic effects of sphingosine 1-phosphate by a zinc- and calcium-dependent mechanism in fibroblasts. Arch Biochem Biophys 1999 Jun 1 3
3 10851233 Extracellular zinc activates p70 S6 kinase through the phosphatidylinositol 3-kinase signaling pathway. J Biol Chem 2000 Aug 25 6
4 11577586 [mTOR and FTY 720 inhibitors]. Presse Med 2001 Sep 1 3
5 11707573 FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse. Proc Natl Acad Sci U S A 2001 Nov 20 1
6 11784055 Exogenous amino acids regulate trophectoderm differentiation in the mouse blastocyst through an mTOR-dependent pathway. Dev Biol 2001 Dec 1 5
7 11875047 A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum Mol Genet 2002 Mar 1 1
8 12668503 Rapamycin attenuates load-induced cardiac hypertrophy in mice. Circulation 2003 Apr 1 1
9 12801981 Amino acid transport regulates blastocyst implantation. Biol Reprod 2003 Oct 3
10 14534328 mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo. Proc Natl Acad Sci U S A 2003 Oct 28 1
11 14559816 The PCPH oncoprotein antagonizes the proapoptotic role of the mammalian target of rapamycin in the response of normal fibroblasts to ionizing radiation. Cancer Res 2003 Oct 1 3
12 14561707 Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR. J Clin Invest 2003 Oct 1
13 14579029 MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612 and 632. Diabetologia 2003 Nov 5
14 14612424 mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF. Mol Cell Biol 2003 Dec 2
15 14623899 Nutrient-dependent and insulin-stimulated phosphorylation of insulin receptor substrate-1 on serine 302 correlates with increased insulin signaling. J Biol Chem 2004 Jan 30 3
16 14625550 Colonic polyposis caused by mTOR-mediated chromosomal instability in Apc+/Delta716 Cdx2+/- compound mutant mice. Nat Genet 2003 Dec 2
17 14634209 Frap, FKBP12 rapamycin-associated protein, is a candidate gene for the plasmacytoma resistance locus Pctr2 and can act as a tumor suppressor gene. Proc Natl Acad Sci U S A 2003 Dec 9 1
18 14970221 Thr2446 is a novel mammalian target of rapamycin (mTOR) phosphorylation site regulated by nutrient status. J Biol Chem 2004 Apr 16 1
19 14976243 Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs. Proc Natl Acad Sci U S A 2004 Mar 2 1
20 15010863 IL2-dependent phosphorylation of 40S ribosomal protein S6 is controlled by PI-3K/mTOR signalling in CTLL2 cells. Int J Mol Med 2004 Apr 2
21 15017384 Osteoclast formation, survival and morphology are highly dependent on exogenous cholesterol/lipoproteins. Cell Death Differ 2004 Jul 1
22 15029198 Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature 2004 Mar 18 1
23 15184287 Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload. Circulation 2004 Jun 22 1
24 15199413 Stable expression of small interfering RNA sensitizes TEL-PDGFbetaR to inhibition with imatinib or rapamycin. J Clin Invest 2004 Jun 1
25 15286700 Prolactin induces c-Myc expression and cell survival through activation of Src/Akt pathway in lymphoid cells. Oncogene 2004 Sep 23 1
26 15338249 Lyophilized carrot ingestion lowers lipemia and beneficially affects cholesterol metabolism in cholesterol-fed C57BL/6J mice. Eur J Nutr 2004 Aug 1
27 15479767 Amino acids and leucine allow insulin activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice. FASEB J 2004 Dec 2
28 15485918 Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol 2004 Nov 1
29 15608593 Microarray analysis of ethanol-treated cortical neurons reveals disruption of genes related to the ubiquitin-proteasome pathway and protein synthesis. Alcohol Clin Exp Res 2004 Dec 1
30 15625701 Mouse embryonic stem cells and preimplantation embryos require signaling through the phosphatidylinositol 3-kinase pathway to suppress apoptosis. Mol Reprod Dev 2005 Mar 1
31 15705789 Pim and Akt oncogenes are independent regulators of hematopoietic cell growth and survival. Blood 2005 Jun 1 1
32 15767444 Roles of the Ras-MEK-mitogen-activated protein kinase and phosphatidylinositol 3-kinase-Akt-mTOR pathways in Jaagsiekte sheep retrovirus-induced transformation of rodent fibroblast and epithelial cell lines. J Virol 2005 Apr 2
33 15781267 Suppression of PI3K/mTOR pathway rescues LLC cells from cell death induced by hypoxia. Biochem Biophys Res Commun 2005 Apr 29 2
34 15781656 Rapamycin inhibits ezrin-mediated metastatic behavior in a murine model of osteosarcoma. Cancer Res 2005 Mar 15 1
35 15833854 Inhibition of mammalian target of rapamycin reverses alveolar epithelial neoplasia induced by oncogenic K-ras. Cancer Res 2005 Apr 15 2
36 15846106 PWT-458, a novel pegylated-17-hydroxywortmannin, inhibits phosphatidylinositol 3-kinase signaling and suppresses growth of solid tumors. Cancer Biol Ther 2005 May 1
37 15897901 Regulation of the phosphorylation and integrity of protein synthesis initiation factor eIF4GI and the translational repressor 4E-BP1 by p53. Oncogene 2005 Jul 14 1
38 15940265 Enhanced radiation damage of tumor vasculature by mTOR inhibitors. Oncogene 2005 Aug 18 1
39 16014032 Gas6 induces Akt/mTOR-mediated mesangial hypertrophy in diabetic nephropathy. Kidney Int 2005 Aug 2
40 16086373 Role of PI3K/Akt signaling in insulin-like growth factor-1 (IGF-1) skin tumor promotion. Mol Carcinog 2005 Oct 1
41 16333141 Targeting the signaling pathway of acylation stimulating protein. J Lipid Res 2006 Mar 1
42 16341243 Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat Med 2006 Jan 1
43 16364254 Inhibition of mTOR signaling with rapamycin attenuates renal hypertrophy in the early diabetic mice. Biochem Biophys Res Commun 2006 Feb 3 2
44 16396989 Differential mitogenic signaling in insulin receptor-deficient fetal pancreatic beta-cells. Endocrinology 2006 Apr 4
45 16413820 Anti-genotoxic effect of Aloysia triphylla infusion against acrylamide-induced DNA damage as shown by the comet assay technique. Mutat Res 2006 Feb 28 1
46 16424025 Effect of rapamycin on mouse chronic lymphocytic leukemia and the development of nonhematopoietic malignancies in Emu-TCL1 transgenic mice. Cancer Res 2006 Jan 15 1
47 16567633 The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proc Natl Acad Sci U S A 2006 Apr 4 1
48 16598206 Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 2006 May 25 1
49 16613881 Activation of the mTOR signalling pathway is required for pancreatic growth in protease-inhibitor-fed mice. J Physiol 2006 Jun 15 1
50 16652094 Everolimus (RAD) inhibits in vivo growth of murine squamous cell carcinoma (SCC VII). Laryngoscope 2006 May 2