trametinib


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339 Functionally related protein(s)
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Protein Name
UniProt Entry
Gene Symbol
Organism
NCBI Gene ID
# All related compound(s)
#Article(s)
1 mitogen-activated protein kinase kinase 7 MP2K7_HUMAN MAP2K7 Homo sapiens 5609 1407 443
2 B-Raf proto-oncogene, serine/threonine kinase BRAF_HUMAN BRAF Homo sapiens 673 872 313
3 mitogen-activated protein kinase kinase 1 MP2K1_HUMAN MAP2K1 Homo sapiens 5604 739 91
4 mitogen-activated protein kinase 1 MK01_HUMAN MAPK1 Homo sapiens 5594 4181 57
5 midkine MK_MOUSE Mdk Mus musculus 17242 501 56
6 KRAS proto-oncogene, GTPase RASK_HUMAN KRAS Homo sapiens 3845 1547 55
7 NRAS proto-oncogene, GTPase RASN_HUMAN NRAS Homo sapiens 4893 357 26
8 epidermal growth factor receptor EGFR_HUMAN EGFR Homo sapiens 1956 4580 26
9 mitogen-activated protein kinase 3 MK03_HUMAN MAPK3 Homo sapiens 5595 3238 23
10 mitogen-activated protein kinase kinase 2 MP2K2_HUMAN MAP2K2 Homo sapiens 5605 75 20
11 AKT serine/threonine kinase 1 AKT1_HUMAN AKT1 Homo sapiens 207 6445 16
12 zinc fingers and homeoboxes 2 ZHX2_HUMAN ZHX2 Homo sapiens 22882 627 16
13 mitogen-activated protein kinase 1 MK01_MOUSE Mapk1 Mus musculus 26413 1992 16
14 Kirsten rat sarcoma viral oncogene homolog RASK_MOUSE Kras Mus musculus 16653 464 11
15 MYC proto-oncogene, bHLH transcription factor MYC_HUMAN MYC Homo sapiens 4609 2261 10
16 mitogen-activated protein kinase kinase 1 MP2K1_MOUSE Map2k1 Mus musculus 26395 224 10
17 erb-b2 receptor tyrosine kinase 2 ERBB2_HUMAN ERBB2 Homo sapiens 2064 2723 8
18 neurofibromin 1 NF1_HUMAN NF1 Homo sapiens 4763 413 7
19 MCL1 apoptosis regulator, BCL2 family member MCL1_HUMAN MCL1 Homo sapiens 4170 1015 7
20 CD274 molecule PD1L1_HUMAN CD274 Homo sapiens 29126 1115 7
21 mitogen-activated protein kinase 3 MK03_MOUSE Mapk3 Mus musculus 26417 1527 7
22 mechanistic target of rapamycin kinase MTOR_HUMAN MTOR Homo sapiens 2475 3411 6
23 eukaryotic translation initiation factor 2 alpha kinase 3 E2AK3_HUMAN EIF2AK3 Homo sapiens 9451 737 6
24 Yes1 associated transcriptional regulator YAP1_HUMAN YAP1 Homo sapiens 10413 666 6
25 tumor protein p53 P53_HUMAN TP53 Homo sapiens 7157 5584 5
26 Braf transforming gene BRAF_MOUSE Braf Mus musculus 109880 159 5
27 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha PK3CA_HUMAN PIK3CA Homo sapiens 5290 683 5
28 erb-b2 receptor tyrosine kinase 3 ERBB3_HUMAN ERBB3 Homo sapiens 2065 299 5
29 fibroblast growth factor receptor 1 FGFR1_HUMAN FGFR1 Homo sapiens 2260 405 5
30 cyclin dependent kinase 4 CDK4_HUMAN CDK4 Homo sapiens 1019 868 4
31 signal transducer and activator of transcription 3 STAT3_HUMAN STAT3 Homo sapiens 6774 2503 4
32 CREB regulated transcription coactivator 1 CRTC1_MOUSE Crtc1 Mus musculus 382056 993 4
33 C-X-C motif chemokine ligand 8 IL8_HUMAN CXCL8 Homo sapiens 3576 4038 4
34 cyclin D1 CCND1_HUMAN CCND1 Homo sapiens 595 1747 4
35 thymoma viral proto-oncogene 1 AKT1_MOUSE Akt1 Mus musculus 11651 3034 4
36 dynactin subunit 6 DCTN6_HUMAN DCTN6 Homo sapiens 10671 338 3
37 EPH receptor A2 EPHA2_HUMAN EPHA2 Homo sapiens 1969 198 3
38 protein tyrosine phosphatase non-receptor type 11 PTN11_HUMAN PTPN11 Homo sapiens 5781 376 3
39 BCL2 like 1 B2CL1_HUMAN BCL2L1 Homo sapiens 598 1360 3
40 catenin beta 1 CTNB1_HUMAN CTNNB1 Homo sapiens 1499 2350 3
41 signal transducer and activator of transcription 1 STAT1_HUMAN STAT1 Homo sapiens 6772 747 3
42 cyclin dependent kinase inhibitor 1B CDN1B_HUMAN CDKN1B Homo sapiens 1027 588 3
43 tumor necrosis factor TNFA_MOUSE Tnf Mus musculus 21926 5931 3
44 transforming growth factor beta 1 TGFB1_HUMAN TGFB1 Homo sapiens 7040 2953 3
45 neuroblastoma ras oncogene Q9D091_MOUSE Nras Mus musculus 18176 68 3
46 fms related receptor tyrosine kinase 3 FLT3_HUMAN FLT3 Homo sapiens 2322 569 3
47 poly(ADP-ribose) polymerase 1 PARP1_HUMAN PARP1 Homo sapiens 142 2571 3
48 ABL proto-oncogene 1, non-receptor tyrosine kinase ABL1_HUMAN ABL1 Homo sapiens 25 989 3
49 mitogen activated protein kinase kinase 1 MP2K1_RAT Map2k1 Rattus norvegicus 170851 269 3
50 heat shock protein 90 alpha family class A member 1 HS90A_HUMAN HSP90AA1 Homo sapiens 3320 1552 3