Pub. Date : 1998 Dec 15
PMID : 9854040
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N). | Cholesterol | SREBF chaperone | Mus musculus |
| 2 | Sterols suppress SREBP cleavage by blocking the action of SCAP, thereby decreasing cholesterol synthesis. | Sterols | SREBF chaperone | Mus musculus |
| 3 | Sterols suppress SREBP cleavage by blocking the action of SCAP, thereby decreasing cholesterol synthesis. | Cholesterol | SREBF chaperone | Mus musculus |
| 4 | We conclude that SCAP(D443N) stimulates proteolytic processing of native SREBPs in liver and decreases the normal sterol-mediated feedback regulation of SREBP cleavage, suggesting a central role for SCAP as a sterol sensor in liver. | Sterols | SREBF chaperone | Mus musculus |
| 5 | We conclude that SCAP(D443N) stimulates proteolytic processing of native SREBPs in liver and decreases the normal sterol-mediated feedback regulation of SREBP cleavage, suggesting a central role for SCAP as a sterol sensor in liver. | Sterols | SREBF chaperone | Mus musculus |
| 6 | We conclude that SCAP(D443N) stimulates proteolytic processing of native SREBPs in liver and decreases the normal sterol-mediated feedback regulation of SREBP cleavage, suggesting a central role for SCAP as a sterol sensor in liver. | Sterols | SREBF chaperone | Mus musculus |