Title : Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

Pub. Date : 1998 Jun 23

PMID : 9636206






11 Functional Relationships(s)
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Protein Name
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1 Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Peroxynitrous Acid tyrosine hydroxylase Mus musculus
2 Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine tyrosine hydroxylase Mus musculus
3 Inactivation of tyrosine hydroxylase by nitration following exposure to peroxynitrite and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine tyrosine hydroxylase Mus musculus
4 Nitration of TH also occurs in mouse striatum after MPTP administration. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine tyrosine hydroxylase Mus musculus
5 Nitration of tyrosine residues in TH results in loss of enzymatic activity. Tyrosine tyrosine hydroxylase Mus musculus
6 In the mouse striatum, tyrosine nitration-mediated loss in TH activity parallels the decline in dopamine levels whereas the levels of TH protein remain unchanged for the first 6 hr post MPTP injection. Tyrosine tyrosine hydroxylase Mus musculus
7 In the mouse striatum, tyrosine nitration-mediated loss in TH activity parallels the decline in dopamine levels whereas the levels of TH protein remain unchanged for the first 6 hr post MPTP injection. Dopamine tyrosine hydroxylase Mus musculus
8 Striatal TH was not nitrated in mice overexpressing copper/zinc superoxide dismutase after MPTP administration, supporting a critical role for superoxide in TH tyrosine nitration. Tyrosine tyrosine hydroxylase Mus musculus
9 These results indicate that tyrosine nitration-induced TH inactivation and consequently dopamine synthesis failure, represents an early and thus far unidentified biochemical event in MPTP neurotoxic process. Tyrosine tyrosine hydroxylase Mus musculus
10 These results indicate that tyrosine nitration-induced TH inactivation and consequently dopamine synthesis failure, represents an early and thus far unidentified biochemical event in MPTP neurotoxic process. Dopamine tyrosine hydroxylase Mus musculus
11 These results indicate that tyrosine nitration-induced TH inactivation and consequently dopamine synthesis failure, represents an early and thus far unidentified biochemical event in MPTP neurotoxic process. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine tyrosine hydroxylase Mus musculus