Title : Vitamin A and carotenoids stimulate differentiation of mouse osteoblastic cells.

Pub. Date : 1997 Jun

PMID : 9268918






5 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Retinol increased the expression of osteopontin mRNA in a range from 1 to 100 nm. Vitamin A secreted phosphoprotein 1 Mus musculus
2 Beta-carotene also increased osteopontin mRNA expression, reaching a plateau at 1 microM. beta Carotene secreted phosphoprotein 1 Mus musculus
3 Alpha-carotene, canthaxanthin and lycopene also inhibited cell proliferation at 1 microM and increased alkaline phosphatase activity and osteopontin mRNA expression, but less potently so than beta-carotene. alpha-carotene secreted phosphoprotein 1 Mus musculus
4 Alpha-carotene, canthaxanthin and lycopene also inhibited cell proliferation at 1 microM and increased alkaline phosphatase activity and osteopontin mRNA expression, but less potently so than beta-carotene. Canthaxanthin secreted phosphoprotein 1 Mus musculus
5 Alpha-carotene, canthaxanthin and lycopene also inhibited cell proliferation at 1 microM and increased alkaline phosphatase activity and osteopontin mRNA expression, but less potently so than beta-carotene. Lycopene secreted phosphoprotein 1 Mus musculus