Pub. Date : 1997 Jan 31
PMID : 9006890
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In three v-Src-transformed fibroblast cell lines (NIH3T3, Balb/c, and 3Y1), JAK1 displayed increased tyrosyl phosphorylation compared to non-transformed cells. | cyclo(tyrosyl-tyrosyl) | Janus kinase 1 | Mus musculus |
| 2 | The level of tyrosyl phosphorylation of JAK1 was significantly greater in NIH3T3 cells transformed by expression of v-Src or high levels of a constitutively active mutant of c-Src (Y527F) than in cells overexpressing the less transforming normal c-Src. | cyclo(tyrosyl-tyrosyl) | Janus kinase 1 | Mus musculus |
| 3 | In anti-JAK1 immunoprecipitates from v-Src-transformed NIH3T3 cells, a protein with the same migration as JAK1 showed substantially increased levels of 32P incorporation compared to immunoprecipitates from non-transformed cells. | Phosphorus-32 | Janus kinase 1 | Mus musculus |
| 4 | In anti-JAK1 immunoprecipitates from v-Src-transformed NIH3T3 cells, a protein with the same migration as JAK1 showed substantially increased levels of 32P incorporation compared to immunoprecipitates from non-transformed cells. | Phosphorus-32 | Janus kinase 1 | Mus musculus |
| 5 | Similar results were obtained using anti-JAK2 immunoprecipitates; however, the level of JAK2 tyrosyl phosphorylation and 32P incorporation in anti-JAK2 immunoprecipitates were markedly lower than in anti-JAK1 immunoprecipitates. | cyclo(tyrosyl-tyrosyl) | Janus kinase 1 | Mus musculus |