Title : Dopamine-deficient mice are severely hypoactive, adipsic, and aphagic.

Pub. Date : 1995 Dec 29

PMID : 8548806






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Mice unable to synthesize dopamine (DA) specifically in dopaminergic neurons were created by inactivating the tyrosine hydroxylase (TH) gene then by restoring TH function in noradrenergic cells. Dopamine tyrosine hydroxylase Mus musculus
2 Mice unable to synthesize dopamine (DA) specifically in dopaminergic neurons were created by inactivating the tyrosine hydroxylase (TH) gene then by restoring TH function in noradrenergic cells. Dopamine tyrosine hydroxylase Mus musculus
3 Within a few minutes of being injected with L-dihdroxyphenylalanine (L-DOPA), the product of TH, the DA-/- mice became more active and consumed more food than control mice. l-dihdroxyphenylalanine tyrosine hydroxylase Mus musculus
4 Within a few minutes of being injected with L-dihdroxyphenylalanine (L-DOPA), the product of TH, the DA-/- mice became more active and consumed more food than control mice. Levodopa tyrosine hydroxylase Mus musculus